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Hyperphagia and Obesity: Title and subTitle BreakRelationship to Medial Hypothalamic Lesions FREE

Gastone G. Celesia, MD; Carol R. Archer, MD; Hyung D. Chung, MD
[+] Author Affiliations

Reprint requests to Department of Neurology, William S. Middleton Memorial Veterans' Hospital, 2500 Overlook Terr, Madison, WI 53705 (Dr Celesia).


JAMA. 1981;246(2):151-153. doi:10.1001/jama.1981.03320020043022
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Progressive left hemiparesis followed by face and trunk cutaneous vasodilation and hyperphagia developed in a 28-year-old man. He began eating five to six meals a day and gained 16 kg in 60 days. Computed tomography disclosed a neoplastic lesion involving the midline via the hypothalamus and reaching the contralateral lenticular nucleus. Findings from endocrine studies, including thyroid-stimulating hormone, growth hormone, prolactin, and cortisol serum levels, were normal. Hyperphagia and consequent obesity were associated with bilateral destruction of the ventromedial hypothalamic area; cutaneous vasodilation was related to involvement of the preoptic area.

(JAMA 1981;246:151-153)

REFERENCES

Anand BK:  Nervous regulation of food intake . Physiol Rev 1962;;41:677-708.
Tepperman J, Brobeck JR, Long CNH:  The effects of hypothalamic hyperphagia and of alterations in feeding habits on the metabolism of the albino rat . Yale J Biol Med 1943;;15:855.
Von Wowern F:  Obesity as a sequel of traumatic injury to the hypothalamus . Dan Med Bull 1966;;13:11-13.
Kamalian N, Keesey RE, ZuRhein GM:  Lateral hypothalamic demyelination and cachexia in a case of 'malignant' multiple sclerosis . Neurology 1975;;25:25-30.
Bray GA, Gallagher TF:  Manifestations of hypothalamic obesity in man: A comprehensive investigation of eight patients and a review of the literature . Medicine 1975;;54:301-330.
Penfield W, Jasper H: Epilepsy and the Functional Anatomy of the Human Brain . Boston, Little Brown & Co, 1954;, pp 414-416.
Oomura Y, Ooyama H, Yamamoto T:  Reciprocal relationship of the lateral and ventromedial hypothalamus in the regulation of food intake . Physiol Behav 1967;;2:97-115.
Gold RM:  Hypothalamic obesity: The myth of the ventromedial nucleus . Science 1973;; 182:488-489.
Kemnitz JW, Goy RW, Kraemer GW:  Hypothalamic obesity in rhesus monkeys: Glucoregulatory and neurochemical correlates , abstracted. Soc Neurosci 1979;;5:219.
Anderson E, Rioch D McK, Haymaker W:  Disturbances in blood sugar regulation in animals subjected to transection of the brain stem . Acta Neuroveg 1952;;5:132-164.

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Anand BK:  Nervous regulation of food intake . Physiol Rev 1962;;41:677-708.
Tepperman J, Brobeck JR, Long CNH:  The effects of hypothalamic hyperphagia and of alterations in feeding habits on the metabolism of the albino rat . Yale J Biol Med 1943;;15:855.
Von Wowern F:  Obesity as a sequel of traumatic injury to the hypothalamus . Dan Med Bull 1966;;13:11-13.
Kamalian N, Keesey RE, ZuRhein GM:  Lateral hypothalamic demyelination and cachexia in a case of 'malignant' multiple sclerosis . Neurology 1975;;25:25-30.
Bray GA, Gallagher TF:  Manifestations of hypothalamic obesity in man: A comprehensive investigation of eight patients and a review of the literature . Medicine 1975;;54:301-330.
Penfield W, Jasper H: Epilepsy and the Functional Anatomy of the Human Brain . Boston, Little Brown & Co, 1954;, pp 414-416.
Oomura Y, Ooyama H, Yamamoto T:  Reciprocal relationship of the lateral and ventromedial hypothalamus in the regulation of food intake . Physiol Behav 1967;;2:97-115.
Gold RM:  Hypothalamic obesity: The myth of the ventromedial nucleus . Science 1973;; 182:488-489.
Kemnitz JW, Goy RW, Kraemer GW:  Hypothalamic obesity in rhesus monkeys: Glucoregulatory and neurochemical correlates , abstracted. Soc Neurosci 1979;;5:219.
Anderson E, Rioch D McK, Haymaker W:  Disturbances in blood sugar regulation in animals subjected to transection of the brain stem . Acta Neuroveg 1952;;5:132-164.
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