0
October 16, 1981, Vol 246, No. 16 >
ARTICLE | October 16, 1981

Infectious Mononucleosis and Acute Leukemia FREE

Fred Rosner, MD; Hans W. Grünwald, MD
[+] Author Affiliations

Reprint requests to Department of Medicine, Long Island Jewish-Hillside Medical Center, 82-68 164 St, Jamaica, NY 11432 (Dr Rosner).


JAMA. 1981;246(16):1783-1784. doi:10.1001/jama.1981.03320160015021
Text Size: A A A
Published online
Article
References

TO OUR knowledge, 26 cases1-15 have been reported of the association of infectious mononucleosis and acute leukemia (Table). In seven instances, the former preceded the latter by one to 36 months, in 16 cases the acute leukemia preceded the infectious mononucleosis by one to 45 months, and in three patients both diseases were diagnosed simultaneously. Twenty-one patients were children or teenagers, perhaps accounting for the 20 cases of acute lymphoblastic leukemia. Three patients had acute monocytic leukemia.

The possible relationship, if any, between the Epstein-Barr (EB) virus, infectious mononucleosis, and acute leukemia is far from clear. Although the EB virus has been etiologically linked to Burkitt's lymphoma, its relation to acute lymphoblastic leukemia has not been established. It seems rather far-fetched to state that the coincidence of acute monocytic leukemia and infectious mononucleosis in two elderly patients suggests a causal relationship.15 Although one report11 suggests that the EB virus

REFERENCES

1 +
Feldman F, Yarvis JJ:  Manifestations of hemolytic phenomena and infectious mononucleosis in a case of lymphatic leukemia . NY State J Med 1944;;44:1693-1694.
2 +
Taylor AW:  Effects of glandular fever infection in acute leukemia . Br Med J 1953;;1:589-593.
3 +
Blom J:  Infectious mononucleosis in acute lymphocytic leukemia . JAMA 1965;;194:27-29.
4 +
Lampkin BC, Canales L, Mauer AM:  Infectious mononucleosis in a child with acute lymphoblastic leukemia . J Pediatr 1967;;71:876-877.
5 +
Ragab AH, Vietti TJ:  Infectious mononucleosis, lymphoblastic leukemia, and the EB virus . Cancer 1969;;24:261-265.
6 +
Freedman MH, Gilchrist GS, Hammond GD:  Concurrent infectious mononucleosis and acute leukemia . JAMA 1970;;214:1677-1680.
7 +
Deardorff WL, Gerber P, Vogler WR:  Infectious mononucleosis in acute leukemia with rising Epstein-Barr virus antibody titers . Ann Intern Med 1970;;72:235-240.
8 +
Stevens DA, Levine PH, Lee SK, et al:  Concurrent infectious mononucleosis and acute leukemia: Case reports: Review of the literature and serologic studies with the herpes-type virus (EB virus) . Am J Med 1971;;50:208-217.
9 +
Sackmann F, Penalver JA:  Mononucleosis infecciosa y leucemia aguda . Sangre 1971;;16:403-410.
10 +
Armata J, Legutko L:  Infectious mononucleosis during remission of acute leukemia in two children . Pol Tyg Lek 1972;;27:530-531.
11 +
Levine P, Stevens D, Coccia P, et al:  Infectious mononucleosis prior to acute leukemia: A possible role for the Epstein-Barr virus . Cancer 1972;;30:875-880.
12 +
Malpuech G, Didier J, Bezou MJ, et al:  Rèvélation simultanée d'une leucémie aiguë lymphoblastique et d'une mononucléose infectieuse . Pediatrie 1973;;28:447-457.
13 +
Langenhuysen MMAC:  Concurrent infectious mononucleosis and acute myelocytic leukemia . Acta Haematol 1974;;51:121-127.
14 +
Pederson PR, Gerber P, Sweeney G, et al:  Infectious mononucleosis preceding acute myelomonocytic leukemia . Am J Med Sci 1975;;269:131-135.
15 +
Hehlmann R, Walther B, Zöllner N, et al:  Infectious mononucleosis and acute monocytic leukaemia . Lancet 1980;;2:652-653.
16 +
Fraumeni JF:  Infectious mononucleosis and acute leukemia . JAMA 1971;;215:1159.
17 +
Janossy G, Bollum FJ, Bradstock KF, et al:  Cellular phenotypes of normal and leukemic hemopoietic cells determined by analysis with selected antibody combinations . Blood 1980;;56:430-441.
18 +
Ozer H, Higby D, Han T, et al:  Heterogeneity of lymphoid leukemic cells and cell lines defined by OKT monoclonal antibodies , abstracted. Proc Am Assoc Cancer Res/Am Soc Clin Oncol 1981;;22:304.
19 +
Magrath IT, Pizzo PA, Whang-Peng J, et al:  Characterization of lymphoma-derived cell lines: Comparison of cell lines positive and negative for Epstein-Barr virus nuclear antigen: I. Physical, cytogenetic and growth characteristics . J Natl Cancer Inst 1980;;64:465-476.
20 +
Magrath IT, Freeman CB, Pizzo P, et al:  Characterization of lymphoma-derived cell lines: Comparison of cell lines positive and negative for Epstein-Barr virus nuclear antigen: II. Surface markers . J Natl Cancer Inst 1980;;64:477-483.
21 +
 Infectious mononucleosis and acute leukaemia , editorial. Lancet 1971;;1:688.

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

1 +
Feldman F, Yarvis JJ:  Manifestations of hemolytic phenomena and infectious mononucleosis in a case of lymphatic leukemia . NY State J Med 1944;;44:1693-1694.
2 +
Taylor AW:  Effects of glandular fever infection in acute leukemia . Br Med J 1953;;1:589-593.
3 +
Blom J:  Infectious mononucleosis in acute lymphocytic leukemia . JAMA 1965;;194:27-29.
4 +
Lampkin BC, Canales L, Mauer AM:  Infectious mononucleosis in a child with acute lymphoblastic leukemia . J Pediatr 1967;;71:876-877.
5 +
Ragab AH, Vietti TJ:  Infectious mononucleosis, lymphoblastic leukemia, and the EB virus . Cancer 1969;;24:261-265.
6 +
Freedman MH, Gilchrist GS, Hammond GD:  Concurrent infectious mononucleosis and acute leukemia . JAMA 1970;;214:1677-1680.
7 +
Deardorff WL, Gerber P, Vogler WR:  Infectious mononucleosis in acute leukemia with rising Epstein-Barr virus antibody titers . Ann Intern Med 1970;;72:235-240.
8 +
Stevens DA, Levine PH, Lee SK, et al:  Concurrent infectious mononucleosis and acute leukemia: Case reports: Review of the literature and serologic studies with the herpes-type virus (EB virus) . Am J Med 1971;;50:208-217.
9 +
Sackmann F, Penalver JA:  Mononucleosis infecciosa y leucemia aguda . Sangre 1971;;16:403-410.
10 +
Armata J, Legutko L:  Infectious mononucleosis during remission of acute leukemia in two children . Pol Tyg Lek 1972;;27:530-531.
11 +
Levine P, Stevens D, Coccia P, et al:  Infectious mononucleosis prior to acute leukemia: A possible role for the Epstein-Barr virus . Cancer 1972;;30:875-880.
12 +
Malpuech G, Didier J, Bezou MJ, et al:  Rèvélation simultanée d'une leucémie aiguë lymphoblastique et d'une mononucléose infectieuse . Pediatrie 1973;;28:447-457.
13 +
Langenhuysen MMAC:  Concurrent infectious mononucleosis and acute myelocytic leukemia . Acta Haematol 1974;;51:121-127.
14 +
Pederson PR, Gerber P, Sweeney G, et al:  Infectious mononucleosis preceding acute myelomonocytic leukemia . Am J Med Sci 1975;;269:131-135.
15 +
Hehlmann R, Walther B, Zöllner N, et al:  Infectious mononucleosis and acute monocytic leukaemia . Lancet 1980;;2:652-653.
16 +
Fraumeni JF:  Infectious mononucleosis and acute leukemia . JAMA 1971;;215:1159.
17 +
Janossy G, Bollum FJ, Bradstock KF, et al:  Cellular phenotypes of normal and leukemic hemopoietic cells determined by analysis with selected antibody combinations . Blood 1980;;56:430-441.
18 +
Ozer H, Higby D, Han T, et al:  Heterogeneity of lymphoid leukemic cells and cell lines defined by OKT monoclonal antibodies , abstracted. Proc Am Assoc Cancer Res/Am Soc Clin Oncol 1981;;22:304.
19 +
Magrath IT, Pizzo PA, Whang-Peng J, et al:  Characterization of lymphoma-derived cell lines: Comparison of cell lines positive and negative for Epstein-Barr virus nuclear antigen: I. Physical, cytogenetic and growth characteristics . J Natl Cancer Inst 1980;;64:465-476.
20 +
Magrath IT, Freeman CB, Pizzo P, et al:  Characterization of lymphoma-derived cell lines: Comparison of cell lines positive and negative for Epstein-Barr virus nuclear antigen: II. Surface markers . J Natl Cancer Inst 1980;;64:477-483.
21 +
 Infectious mononucleosis and acute leukaemia , editorial. Lancet 1971;;1:688.

Letters

Submit a Letter
CME Course for:


You need to register in order to view this quiz.


To understand the clinical management of acute heart failure syndromes.
Accreditation Information The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
To view and print your certificate and access a summary of your CME courses go to My CME.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s “Cited By” API will populate this tab (http://www.crossref.org/citedby.html).
Compression-Only CPR: Pushing the Science Forward
Cone
AAM 2010;304:1493-1495.
All you need to read in the other general journals
BMJ 2010;341:c5893-c1494.
Submit a Response

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

© 2012 American Medical Association. All Rights Reserved.
Powered bySilverchair Information Systems