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ARTICLE |

Enteral and Parenteral Nutrition in the Care of the Cancer Patient FREE

William D. DeWys, MD; Thomas T. Kubota, MD
[+] Author Affiliations

Reprint requests to Nutrition Section, Clinical Investigations Branch, National Cancer Institute, Bethesda, MD 20205 (Dr DeWys).


JAMA. 1981;246(15):1725-1727. doi:10.1001/jama.1981.03320150065038
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WEIGHT loss in cancer patients is caused by decreased caloric intake, increased caloric consumption, and altered host metabolism. In patients with small or modest caloric deficits, caloric balance may often be restored by dietary counseling and oral nutritional supplements. For patients with moderate to severe caloric deficits or physical problems interfering with oral intake, enteral or parenteral routes of nutritional supplementation should be considered. In a previous article in this series, general principles of nutritional care of the cancer patient were reviewed.1 This article is concerned with technical aspects of the enteral and parenteral routes of nutrition for cancer patients and with possible indications for their use.

Enteral Nutrition  Enteral feeding may be accomplished via tubes inserted through various routes: nasogastric, pharyngostomy, esophagostomy, gastrostomy, or jejunostomy. The nasogastric route is used most often. For most patients, we recommend the use of an 8 F silicone tubing (the small-bore pediatric

REFERENCES

DeWys WD:  Nutritional care of the cancer patient . JAMA 1980;;244:374-376.
Rombeau JL, Barot LR:  Enteral nutritional therapy . Surg Clin North Am , to be published.
Heymsfield SB, Bethel RA, Ansley JD, et al:  Enteral hyperalimentation: An alternative to central venous hyperalimentation . Ann Intern Med 1979;;90:63-71.
Donaldson SS, Jundt S, Ricour C, et al:  Radiation enteritis in children . Cancer 1975;; 35:1167-1178.
Dudrick SJ, MacFadyen BV Jr, Souclon EA, et al:  Parenteral nutrition techniques in cancer patients . Cancer Res 1977;;37:2440-2456.
Grant JP: Handbook of Total Parenteral Nutrition . Philadelphia, WB Saunders Co, 1980;.
Holroyde CP, Myers RN, Smink RD, et al:  Metabolic response to total parenteral nutrition in cancer patients . Cancer Res 1977;;37:3109-3114.
Jeejeebhoy KN:  Is more better? Is weight water? The significance of weight gain during parenteral nutrition with amino acids and dextrose . Gastroenterology 1979;;77:799-800.
Copeland EM III, Daly JM, Ota DM, et al:  Nutrition, cancer, and intravenous hyperalimentation . Cancer 1979;;43:2108-2116.
Cameron IL, Pavlat WA:  Stimulation of growth of a transplantable hepatoma in rats by parenteral nutrition . J Natl Cancer Inst 1976;; 56:597-602.
Steiger E, Oram-Smith J, Miller E, et al:  Effects of nutrition on tumor growth and tolerance to chemotherapy . J Surg Res 1975;;18:455-461.
Nixon DW, Lawson DH, Kutner M, et al:  Hyperalimentation of the cancer patient with protein-caloric undernutrition . Cancer Res , to be published.
Holter AR, Fischer JE:  The effects of perioperative hyperalimentation on complications in patients with carcinoma and weight loss . J Surg Res 1977;;23:31-34.
Valerio D, Overett L, Malcolm A, et al:  Nutritional support for cancer patients receiving abdominal and pelvic radiotherapy: A randomized preoperative clinical experiment of intravenous versus oral feeding . Surg Forum 1978;; 29:145-147.
Donaldson SS, Wesley MN, DeWys WD, et al:  A prospective randomized clinical trial of the value of total parenteral nutrition in children with cancer . Am J Dis Child , to be published.
Issell BV, Valdivieso M, Zaren MA, et al:  Protection against chemotherapy toxicity by IV hyperalimentation . Cancer Treat Rep 1978;; 62:1139-1143.
Goodgame JT:  A critical assessment of the indications for total parenteral nutrition . Surg Gynecol Obstet 1980;;151:433-441.
Fisher RI, DeVita VT, Hubbard SM, et al:  Pro MACE-MOPP combination chemotherapy: Treatment of diffuse lymphomas . Proc Am Assoc Cancer Res Am Soc Clin Oncol 1980;;21:468.
Popp MB, Fisher RI, Simon RM, et al:  A prospective randomized study of adjuvant parenteral nutrition in the treatment of diffuse lymphoma: I. Effect on drug tolerance . Cancer Treat Rep , to be published.

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DeWys WD:  Nutritional care of the cancer patient . JAMA 1980;;244:374-376.
Rombeau JL, Barot LR:  Enteral nutritional therapy . Surg Clin North Am , to be published.
Heymsfield SB, Bethel RA, Ansley JD, et al:  Enteral hyperalimentation: An alternative to central venous hyperalimentation . Ann Intern Med 1979;;90:63-71.
Donaldson SS, Jundt S, Ricour C, et al:  Radiation enteritis in children . Cancer 1975;; 35:1167-1178.
Dudrick SJ, MacFadyen BV Jr, Souclon EA, et al:  Parenteral nutrition techniques in cancer patients . Cancer Res 1977;;37:2440-2456.
Grant JP: Handbook of Total Parenteral Nutrition . Philadelphia, WB Saunders Co, 1980;.
Holroyde CP, Myers RN, Smink RD, et al:  Metabolic response to total parenteral nutrition in cancer patients . Cancer Res 1977;;37:3109-3114.
Jeejeebhoy KN:  Is more better? Is weight water? The significance of weight gain during parenteral nutrition with amino acids and dextrose . Gastroenterology 1979;;77:799-800.
Copeland EM III, Daly JM, Ota DM, et al:  Nutrition, cancer, and intravenous hyperalimentation . Cancer 1979;;43:2108-2116.
Cameron IL, Pavlat WA:  Stimulation of growth of a transplantable hepatoma in rats by parenteral nutrition . J Natl Cancer Inst 1976;; 56:597-602.
Steiger E, Oram-Smith J, Miller E, et al:  Effects of nutrition on tumor growth and tolerance to chemotherapy . J Surg Res 1975;;18:455-461.
Nixon DW, Lawson DH, Kutner M, et al:  Hyperalimentation of the cancer patient with protein-caloric undernutrition . Cancer Res , to be published.
Holter AR, Fischer JE:  The effects of perioperative hyperalimentation on complications in patients with carcinoma and weight loss . J Surg Res 1977;;23:31-34.
Valerio D, Overett L, Malcolm A, et al:  Nutritional support for cancer patients receiving abdominal and pelvic radiotherapy: A randomized preoperative clinical experiment of intravenous versus oral feeding . Surg Forum 1978;; 29:145-147.
Donaldson SS, Wesley MN, DeWys WD, et al:  A prospective randomized clinical trial of the value of total parenteral nutrition in children with cancer . Am J Dis Child , to be published.
Issell BV, Valdivieso M, Zaren MA, et al:  Protection against chemotherapy toxicity by IV hyperalimentation . Cancer Treat Rep 1978;; 62:1139-1143.
Goodgame JT:  A critical assessment of the indications for total parenteral nutrition . Surg Gynecol Obstet 1980;;151:433-441.
Fisher RI, DeVita VT, Hubbard SM, et al:  Pro MACE-MOPP combination chemotherapy: Treatment of diffuse lymphomas . Proc Am Assoc Cancer Res Am Soc Clin Oncol 1980;;21:468.
Popp MB, Fisher RI, Simon RM, et al:  A prospective randomized study of adjuvant parenteral nutrition in the treatment of diffuse lymphoma: I. Effect on drug tolerance . Cancer Treat Rep , to be published.
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