0
September 25, 1981, Vol 246, No. 13 >
ARTICLE | September 25, 1981

Platelet Monoamine Oxidase Values and Genetic Heterogeneity in Schizophrenia Research FREE

Miron Baron, MD; Morton Levitt, PhD; Richard Perlman, PhD
[+] Author Affiliations

Reprint requests to Department of Psychiatry, New York State Psychiatric Institute, 722 W 168th St, New York, NY 10032 (Dr Baron).


JAMA. 1981;246(13):1418-1421. doi:10.1001/jama.1981.03320130024017
Text Size: A A A
Published online
Article
References

Platelet monoamine oxidase (MAO) activity is significantly reduced in chronic schizophrenics with family history of schizophrenia. The degree of reduction is related to the extent of genetic load. Schizophrenics with no affected relatives do not differ from control subjects. These findings are consistent with the hypothesis of genetic heterogeneity in schizophrenia. Discrepancies among previously reported data sets can thus be explained by overrepresentation of nongenetic phenocopies with normal MAO levels. The implications for biologic and genetic research in schizophrenia are discussed.

(JAMA 1981;246:1418-1421)

REFERENCES

1 +
Matthysse S, Kidd KK:  Estimating the genetic contribution to schizophrenia . Am J Psychiatry 1976;;133:185-191.
2 +
Wyatt RJ, Potkin SG, Murphy DC:  Platelet monoamine oxidase activity in schizophrenia: A review of the data . Am J Psychiatry 1979;; 136:377-385.
3 +
Spitzer RL, Endicott J, Robins E:  Research diagnostic criteria: Rationale and Reliability . Arch Gen Psychiatry 1978;;35:773-782.
4 +
Endicott J, Spitzer RL:  A diagnostic interview: The Schedule for Affective Disorders and Schizophrenia . Arch Gen Psychiatry 1978;;35:837-849.
5 +
Wyatt RJ, Potkin SG, Gillin JC, et al:  Enzymes involved in phenylethylamine and catecholamine metabolism in schizophrenias and controls , in Lipton MA, DiMascio A, Killam KF (eds): Psychopharmacology: A Generation of Progress . New York, Raven Press, 1978;, pp 1083-1095.
6 +
Endicott J, Andreasen N, Spitzer RL: Family History Research Diagnostic Criteria (FHRDC) . New York, Biometrics Research, New York State Psychiatric Institute, 1978;.
7 +
Baron M: Schedule for Interviewing Borderlines (SIB) . New York, New York State Psychiatric Institute, 1979;.
8 +
Baron M, Asnis L, Gruen R:  The Schedule for Schizotypal Personalities (SSP): A diagnostic interview for schizotypal features . Psychiatr Res , to be published.
9 +
Spitzer RL, Endicott J, Gibbon M:  Crossing the border into borderline personality and borderline schizophrenia . Arch Gen Psychiatry 1979;;36:17-23.
10 +
Kety SS, Rosenthal D, Wender PH, et al:  Mental illness in the biological and adoptive families of adopted individuals who have become schizophrenic , in Fieve R, Brill H, Rosenthal D (eds): Genetic Research in Psychiatry . Baltimore, The Johns Hopkins University Press, 1975;, pp 147-166.
11 +
Murphy DL, Donnelly DH, Miller L, et al:  Platelet monoamine oxidase in chronic schizophrenia: Some enzyme characteristics relevant to reduced activity . Arch Gen Psychiatry 1979;; 33:1377-1381.
12 +
Buchsbaum MS, Rieder RO:  Biologic heterogeneity and psychiatric research . Arch Gen Psychiatry 1979;;36:1163-1169.
13 +
Baron M, Levitt M:  Platelet monoamine oxidase activity: Relation to genetic load of schizophrenia . Psychiatr Res 1980;;3:69-74.
14 +
Belmaker RH, Galon A, Perez L, et al:  Platelet MAO in schizophrenics with and without family history of schizophrenia . Br J Psychiatry 1978;;131:551-552.
15 +
Elston RC, Stewart J:  A general method for the genetic analysis of pedigree data . Hum Hered 1971;;21:523-542.
16 +
Morton NE, MacLean CJ:  Analysis of family resemblance: III. Complex segregation of quantitative traits . Am J Hum Genet 1979;; 26:489-503.
17 +
Ghangas GS, Milman G:  Hypoxanthine phosphoribosyltransferase: Two-dimensional gels from normal and Lesch-Nyhan hemolyzates . Science 1977;;196:1119-1120.
18 +
Nelson DL, Herbet A, Petillot Y, et al: (3H)  Harmaline as a specific ligand of MAOA-I: Properties of the active site of MAO A from rat and bovine brains . J Neurochem 1979;;32:1817-1827.

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

1 +
Matthysse S, Kidd KK:  Estimating the genetic contribution to schizophrenia . Am J Psychiatry 1976;;133:185-191.
2 +
Wyatt RJ, Potkin SG, Murphy DC:  Platelet monoamine oxidase activity in schizophrenia: A review of the data . Am J Psychiatry 1979;; 136:377-385.
3 +
Spitzer RL, Endicott J, Robins E:  Research diagnostic criteria: Rationale and Reliability . Arch Gen Psychiatry 1978;;35:773-782.
4 +
Endicott J, Spitzer RL:  A diagnostic interview: The Schedule for Affective Disorders and Schizophrenia . Arch Gen Psychiatry 1978;;35:837-849.
5 +
Wyatt RJ, Potkin SG, Gillin JC, et al:  Enzymes involved in phenylethylamine and catecholamine metabolism in schizophrenias and controls , in Lipton MA, DiMascio A, Killam KF (eds): Psychopharmacology: A Generation of Progress . New York, Raven Press, 1978;, pp 1083-1095.
6 +
Endicott J, Andreasen N, Spitzer RL: Family History Research Diagnostic Criteria (FHRDC) . New York, Biometrics Research, New York State Psychiatric Institute, 1978;.
7 +
Baron M: Schedule for Interviewing Borderlines (SIB) . New York, New York State Psychiatric Institute, 1979;.
8 +
Baron M, Asnis L, Gruen R:  The Schedule for Schizotypal Personalities (SSP): A diagnostic interview for schizotypal features . Psychiatr Res , to be published.
9 +
Spitzer RL, Endicott J, Gibbon M:  Crossing the border into borderline personality and borderline schizophrenia . Arch Gen Psychiatry 1979;;36:17-23.
10 +
Kety SS, Rosenthal D, Wender PH, et al:  Mental illness in the biological and adoptive families of adopted individuals who have become schizophrenic , in Fieve R, Brill H, Rosenthal D (eds): Genetic Research in Psychiatry . Baltimore, The Johns Hopkins University Press, 1975;, pp 147-166.
11 +
Murphy DL, Donnelly DH, Miller L, et al:  Platelet monoamine oxidase in chronic schizophrenia: Some enzyme characteristics relevant to reduced activity . Arch Gen Psychiatry 1979;; 33:1377-1381.
12 +
Buchsbaum MS, Rieder RO:  Biologic heterogeneity and psychiatric research . Arch Gen Psychiatry 1979;;36:1163-1169.
13 +
Baron M, Levitt M:  Platelet monoamine oxidase activity: Relation to genetic load of schizophrenia . Psychiatr Res 1980;;3:69-74.
14 +
Belmaker RH, Galon A, Perez L, et al:  Platelet MAO in schizophrenics with and without family history of schizophrenia . Br J Psychiatry 1978;;131:551-552.
15 +
Elston RC, Stewart J:  A general method for the genetic analysis of pedigree data . Hum Hered 1971;;21:523-542.
16 +
Morton NE, MacLean CJ:  Analysis of family resemblance: III. Complex segregation of quantitative traits . Am J Hum Genet 1979;; 26:489-503.
17 +
Ghangas GS, Milman G:  Hypoxanthine phosphoribosyltransferase: Two-dimensional gels from normal and Lesch-Nyhan hemolyzates . Science 1977;;196:1119-1120.
18 +
Nelson DL, Herbet A, Petillot Y, et al: (3H)  Harmaline as a specific ligand of MAOA-I: Properties of the active site of MAO A from rat and bovine brains . J Neurochem 1979;;32:1817-1827.

Letters

Submit a Letter
CME Course for:


You need to register in order to view this quiz.


To understand the clinical management of acute heart failure syndromes.
Accreditation Information The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
To view and print your certificate and access a summary of your CME courses go to My CME.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s “Cited By” API will populate this tab (http://www.crossref.org/citedby.html).
Compression-Only CPR: Pushing the Science Forward
Cone
AAM 2010;304:1493-1495.
All you need to read in the other general journals
BMJ 2010;341:c5893-c1494.
Submit a Response

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

© 2012 American Medical Association. All Rights Reserved.
Powered bySilverchair Information Systems