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July 3, 1981, Vol 246, No. 1 >
ARTICLE | July 3, 1981

The Role of Radioimmunodetection in the Management of Testicular Cancer FREE

Nasser Javadpour, MD; E. Edmund Kim, MD; Frank H. DeLand, MD; Jimmy R. Salyer; Usha Shah; David M. Goldenberg, ScD, MD
[+] Author Affiliations

Reprint requests to Division of Experimental Pathology, MS-409, University of Kentucky College of Medicine, Lexington, KY 40536 (Dr Goldenberg).


JAMA. 1981;246(1):45-49. doi:10.1001/jama.1981.03320010025023
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References

Five patients with testicular cancer received an intravenous injection of between 1 and 2.5 mCi of iodine 131—labeled antibody to human chorionic gonadotropin (HCG) or α-fetoprotein (AFP), followed by total-body photoscanning to visualize areas of abnormal radioactivity. Blood-pool and nontarget sites of radioactivity were reduced by subtracting the images derived by injection of technetium Tc 99m—labeled components from the iodine 131 scans. The HCG-immune scintiscans proved helpful in tumor localization and in the selection of appropriate therapy, while the AFP scan presented corroborative evidence of widespread tumor. Elevated serum levels of these two markers did not hinder successful tumor detection and localization by this method of radioimmunodetection. Cancer radioimmunodetection with antibodies to HCG and to AFP appears to be a useful procedure for the pretreatment and posttreatment evaluation of patients with testicular cancer and can reveal sites of tumor not detected by other methods.

(JAMA 1981;246:45-49)

REFERENCES

1 +
Fraley EE, Lange PH, Kennedy BJ:  Germcell testicular cancer in adults . N Engl J Med 1979;;301:1370-1377, 1420-1426.
2 +
Javadpour N:  The value of biologic markers in diagnosis and treatment of testicular cancer . Semin Oncol 1979;;6:37-47.
3 +
Javadpour N:  The role of biologic markers in testicular cancer . Cancer 1980;;45:1755-1761.
4 +
Goldenberg DM:  Immunodiagnosis and immunodetection of colorectal cancer . Cancer Bull 1978;;30:213-218.
5 +
Goldenberg DM:  An introduction to the radioimmunodetection of cancer . Cancer Res 1980;;40:2957-2959.
6 +
Goldenberg DM, DeLand FH, Kim E, et al:  Use of radiolabeled antibodies to carcinoembryonic antigen for the detection and localization of diverse cancers by external photoscanning . N Engl J Med 1978;;298:1384-1388.
7 +
Goldenberg DM, Kim EE, Deland FH, et al:  Radioimmunodetection of cancer with radioactive antibodies to carcinoembryonic antigen . Cancer Res 1980;;40:2984-2992.
8 +
Goldenberg DM, Kim EE, DeLand F, et al:  Clinical studies on the radioimmunodetection of tumors containing alpha-fetoprotein . Cancer 1980;;45:2500-2505.
9 +
Kim EE, Deland FH, Nelson MO, et al:  Radioimmunodetection with radiolabeled antibodies to α-fetoprotein . Cancer Res 1980;;40:3008-3012.
10 +
Goldenberg DM, Kim EE, DeLand FH, et al:  Clinical radioimmunodetection of cancer using radioactive antibodies to human chorionic gonadotropin . Science 1980;;208:1284-1286.
11 +
DeLand FH, Kim EE, Simmons G, et al:  Imaging approach in radioimmunodetection . Cancer Res 1980;;40:3046-3049.
12 +
Waldmann TA, McIntire KR:  The use of a radioimmunoassay for alpha-fetoprotein in the diagnosis of malignancy . Cancer 1974;;34:1510-1515.
13 +
Javadpour N, McIntire KR, Waldmann TA:  Immunochemical determination of human chorionic gonadotropin (HCG) and alpha-fetoprotein (AFP) in sera and tumors of patients with testicular cancer . Natl Cancer Inst Monogr 1978;;49:209-213.
14 +
Quinones J, Mizejewski G, Beierwaltes WH:  Choriocarcinoma scanning using radiolabeled antibody to chorionic gonadotrophin . J Nucl Med 1971;;12:68-75.
15 +
Begent RHJ, Searle F, Stanway G, et al:  Radioimmunolocalization of tumours by external scintigraphy after administration of 131I antibody to human chorionic gonadotrophin: Preliminary communication . J R Soc Med 1980;; 73:624-630.
16 +
Kurman RJ, Scardino PT, McIntire KR, et al:  Cellular localization of alpha-fetoprotein and human chorionic gonadotropin in germ cell tumors of the testis using an indirect immunoperoxidase technique: A new approach to classification utilizing tumor markers . Cancer 1977;; 40:2136-2151.
17 +
Catalone WJ:  Tumor markers in testicular cancer . Urol Clin North Am 1979;;6:613-628.
18 +
Braunstein GD, McIntire KR, Waldmann TA:  Discordance of human chorionic gonadotropin and alpha-fetoprotein in testicular teratocarcinomas . Cancer 1973;;31:1065-1068.
19 +
Wilson JM, Woodhead DM:  Prognostic and therapeutic implications of urinary gonadotropin levels in the management of testicular neoplasia . J Urol 1972;;108:754-756.

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Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

1 +
Fraley EE, Lange PH, Kennedy BJ:  Germcell testicular cancer in adults . N Engl J Med 1979;;301:1370-1377, 1420-1426.
2 +
Javadpour N:  The value of biologic markers in diagnosis and treatment of testicular cancer . Semin Oncol 1979;;6:37-47.
3 +
Javadpour N:  The role of biologic markers in testicular cancer . Cancer 1980;;45:1755-1761.
4 +
Goldenberg DM:  Immunodiagnosis and immunodetection of colorectal cancer . Cancer Bull 1978;;30:213-218.
5 +
Goldenberg DM:  An introduction to the radioimmunodetection of cancer . Cancer Res 1980;;40:2957-2959.
6 +
Goldenberg DM, DeLand FH, Kim E, et al:  Use of radiolabeled antibodies to carcinoembryonic antigen for the detection and localization of diverse cancers by external photoscanning . N Engl J Med 1978;;298:1384-1388.
7 +
Goldenberg DM, Kim EE, Deland FH, et al:  Radioimmunodetection of cancer with radioactive antibodies to carcinoembryonic antigen . Cancer Res 1980;;40:2984-2992.
8 +
Goldenberg DM, Kim EE, DeLand F, et al:  Clinical studies on the radioimmunodetection of tumors containing alpha-fetoprotein . Cancer 1980;;45:2500-2505.
9 +
Kim EE, Deland FH, Nelson MO, et al:  Radioimmunodetection with radiolabeled antibodies to α-fetoprotein . Cancer Res 1980;;40:3008-3012.
10 +
Goldenberg DM, Kim EE, DeLand FH, et al:  Clinical radioimmunodetection of cancer using radioactive antibodies to human chorionic gonadotropin . Science 1980;;208:1284-1286.
11 +
DeLand FH, Kim EE, Simmons G, et al:  Imaging approach in radioimmunodetection . Cancer Res 1980;;40:3046-3049.
12 +
Waldmann TA, McIntire KR:  The use of a radioimmunoassay for alpha-fetoprotein in the diagnosis of malignancy . Cancer 1974;;34:1510-1515.
13 +
Javadpour N, McIntire KR, Waldmann TA:  Immunochemical determination of human chorionic gonadotropin (HCG) and alpha-fetoprotein (AFP) in sera and tumors of patients with testicular cancer . Natl Cancer Inst Monogr 1978;;49:209-213.
14 +
Quinones J, Mizejewski G, Beierwaltes WH:  Choriocarcinoma scanning using radiolabeled antibody to chorionic gonadotrophin . J Nucl Med 1971;;12:68-75.
15 +
Begent RHJ, Searle F, Stanway G, et al:  Radioimmunolocalization of tumours by external scintigraphy after administration of 131I antibody to human chorionic gonadotrophin: Preliminary communication . J R Soc Med 1980;; 73:624-630.
16 +
Kurman RJ, Scardino PT, McIntire KR, et al:  Cellular localization of alpha-fetoprotein and human chorionic gonadotropin in germ cell tumors of the testis using an indirect immunoperoxidase technique: A new approach to classification utilizing tumor markers . Cancer 1977;; 40:2136-2151.
17 +
Catalone WJ:  Tumor markers in testicular cancer . Urol Clin North Am 1979;;6:613-628.
18 +
Braunstein GD, McIntire KR, Waldmann TA:  Discordance of human chorionic gonadotropin and alpha-fetoprotein in testicular teratocarcinomas . Cancer 1973;;31:1065-1068.
19 +
Wilson JM, Woodhead DM:  Prognostic and therapeutic implications of urinary gonadotropin levels in the management of testicular neoplasia . J Urol 1972;;108:754-756.

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