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ARTICLE |

MB Fraction of Creatine Kinase-Reply FREE

Arthur J. Siegel, MD; David M. Dawson, MD
JAMA. 1981;245(23):2394-2394. doi:10.1001/jama.1981.03310480013010
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In Reply.—  Dilution of total CK activity to 300 IU/L before isoenzyme separation will minimize the chance of detecting CK-MB positivity from a skeletal source. Our point is that transient elevations of CK-MB in serum, as has been reported after injury to drivers in automobile accidents,1 may be nonspecific rather than reflect myocardial damage. We agree that dilution may adversely affect CK-MB sensitivity for myocardial injury, but this is a limitation inherent in the technique.

REFERENCES

Lindsey D, Navin TR, Finley PR:  Transient elevations of serum activity of MB isoenzyme of creatine phosphokinase in drivers involved in automobile accidents . Chest 1978;;74:15-18.

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Lindsey D, Navin TR, Finley PR:  Transient elevations of serum activity of MB isoenzyme of creatine phosphokinase in drivers involved in automobile accidents . Chest 1978;;74:15-18.
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