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February 6, 1981, Vol 245, No. 5 >
ARTICLE | February 6, 1981

Comparison of Antihypertensive Effects of Captopril and Propranolol in Essential Hypertension FREE

Chia M. Huang, MD; Francesco del Greco, MD; Antonio Quintanilla, MD; Agostino Molteni, MD, PhD
[+] Author Affiliations

Reprint requests to Veterans Administration Lakeside Medical Center, 333 E Huron St, Chicago, IL 60611 (Dr Huang).


JAMA. 1981;245(5):478-482. doi:10.1001/jama.1981.03310300032015
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References

The antihypertensive effects of the oral converting enzyme inhibitor captopril and of propranolol were evaluated in a single-blind trial of 12 weeks in 19 ambulatory men with moderated essential hypertension (supine diastolic blood pressure [DPB], 100 to 120 mm Hg after receiving placebo for two weeks) whose sodium intake was unrestricted. The captopril group included 12 patients and the propranolol group seven. After the initial dose-finding period of four weeks, supine DBP was significantly reduced in eight patients receiving captopril and in four of the patients receiving propranolol. In these patients DBP decreased throughout the following eight weeks. In the remaining patients from each group, DBP was not reduced by either drug given alone at maximum allowable dosages during dose-finding periods, nor by combined administration in following weeks. No adverse side effects attributable to captopril were noted, except in one patient in whom proteinuria developed after seven weeks. Captopril has potential value in the treatment of moderate essential hypertension.

(JAMA 1981;245:478-482)

REFERENCES

1 +
Cushman DW, Cheung HS, Sabo EF, et al:  Development of specific inhibitors of angiotensin I converting enzyme (kininase II) . Fed Proc 1979;;38:2778-2782.
2 +
Gavras H, Brunner HR, Turini GA, et al:  Antihypertensive effect of the oral angiotensin converting enzyme inhibitor SQ 14,225 in man . N Engl J Med 1978;;298:991-995.
3 +
Case DB, Atlas SA, Laragh JH, et al:  Clinical experience with blockade of the reninangiotensin-aldosterone system by an oral converting enzyme inhibitor (SQ 14,225, captopril) in hypertensive patients . Prog Cardiovasc Dis 1978;;21:195-206.
4 +
Bravo EL, Tarazi RC:  Converting enzyme inhibition with an orally active compound in hypertensive man . Hypertension 1979;;1:39-46.
5 +
Atkinson AB, Lever AF, Brown JJ, et al:  Combined treatment of severe intractable hypertension with captopril and diuretic . Lancet 1980;;2:105-107.
6 +
Sullivan JM, Ginsburg BA, Ratts TE, et al:  Hemodynamic and antihypertensive effects of captopril, an orally active angiotensin converting enzyme inhibitor . Hypertension 1979;; 1:397-401.
7 +
Johnston CI, McGrath BP, Millar JA, et al:  Long-term effects of captopril (SQ 14,225) on blood pressure and hormone levels in essential hypertension . Lancet 1979;;2:493-496.
8 +
MacGregor GA, Markandu ND, Roulston JE, et al:  Essential hypertension: Effect of an oral inhibitor of angiotensin-converting enzyme . Br Med J 1979;;2:1106-1109.
9 +
Brunner HR, Gavras H, Waeber B, et al:  Oral angiotensin converting enzyme inhibitor in long term treatment of hypertensive patients . Ann Intern Med 1979;;90:19-23.
10 +
Johns DW, Baker KM, Ayers CR, et al:  Acute and chronic effect of captopril in hypertensive patients . Hypertension 1980;;2:567-575.
11 +
Buhler FR, Laragh JH, Baer L, et al:  Propranolol inhibition of renin secretion: A specific approach to diagnosis and treatment of renin-dependent hypertensive diseases . N Engl J Med 1972;;287:1209-1214.
12 +
Del Greco F, Simon NM, Roguska J, et al:  Hemodynamic studies in chronic uremia . Circulation 1969;;40:87-95.
13 +
Sealey JE, Laragh JH:  How to do a plasma renin assay . Cardiovasc Med 1977;;2:1079-1092.
14 +
Laragh JH, Case DB, Atlas SA, et al:  Captopril compared with other antirenin system agents in hypertensive patients: Its triphasic effects on blood pressure and its use to identify and treat the renin factor . Hypertension 1980;; 2:586-593.
15 +
Bravo EL, Tarazi RC, Dustan HP, et al:  Dissociation between renin and arterial pressure responses to beta adrenergic blockade in human essential hypertension . Circ Res 1975;;36-37( (suppl 1) ):241-247.
16 +
 Propranolol in the treatment of essential hypertension, Veterans Administration Cooperative Study Group on Antihypertensive Agents . JAMA 1977;;237:2303-2310.
17 +
Tarazi RC, Bravo EL, Fouad FM, et al:  Hemodynamic and volume changes associated with captopril . Hypertension 1980;;2:576-585.
18 +
Swartz SL, Williams GH, Hollenberg NK, et al:  Captopril-induced changes in prostaglandin production . J Clin Invest 1980;;65:1257-1264.
19 +
Michelakis AM, McAllister RG:  Effect of chronic adrenergic receptor blockade on plasma renin activity in man . J Clin Endocrinol 1972;; 34:386-394.
20 +
Captopril:  Benefits and risks in severe hypertension , editorial. Lancet 1980;;2:129-130.

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1 +
Cushman DW, Cheung HS, Sabo EF, et al:  Development of specific inhibitors of angiotensin I converting enzyme (kininase II) . Fed Proc 1979;;38:2778-2782.
2 +
Gavras H, Brunner HR, Turini GA, et al:  Antihypertensive effect of the oral angiotensin converting enzyme inhibitor SQ 14,225 in man . N Engl J Med 1978;;298:991-995.
3 +
Case DB, Atlas SA, Laragh JH, et al:  Clinical experience with blockade of the reninangiotensin-aldosterone system by an oral converting enzyme inhibitor (SQ 14,225, captopril) in hypertensive patients . Prog Cardiovasc Dis 1978;;21:195-206.
4 +
Bravo EL, Tarazi RC:  Converting enzyme inhibition with an orally active compound in hypertensive man . Hypertension 1979;;1:39-46.
5 +
Atkinson AB, Lever AF, Brown JJ, et al:  Combined treatment of severe intractable hypertension with captopril and diuretic . Lancet 1980;;2:105-107.
6 +
Sullivan JM, Ginsburg BA, Ratts TE, et al:  Hemodynamic and antihypertensive effects of captopril, an orally active angiotensin converting enzyme inhibitor . Hypertension 1979;; 1:397-401.
7 +
Johnston CI, McGrath BP, Millar JA, et al:  Long-term effects of captopril (SQ 14,225) on blood pressure and hormone levels in essential hypertension . Lancet 1979;;2:493-496.
8 +
MacGregor GA, Markandu ND, Roulston JE, et al:  Essential hypertension: Effect of an oral inhibitor of angiotensin-converting enzyme . Br Med J 1979;;2:1106-1109.
9 +
Brunner HR, Gavras H, Waeber B, et al:  Oral angiotensin converting enzyme inhibitor in long term treatment of hypertensive patients . Ann Intern Med 1979;;90:19-23.
10 +
Johns DW, Baker KM, Ayers CR, et al:  Acute and chronic effect of captopril in hypertensive patients . Hypertension 1980;;2:567-575.
11 +
Buhler FR, Laragh JH, Baer L, et al:  Propranolol inhibition of renin secretion: A specific approach to diagnosis and treatment of renin-dependent hypertensive diseases . N Engl J Med 1972;;287:1209-1214.
12 +
Del Greco F, Simon NM, Roguska J, et al:  Hemodynamic studies in chronic uremia . Circulation 1969;;40:87-95.
13 +
Sealey JE, Laragh JH:  How to do a plasma renin assay . Cardiovasc Med 1977;;2:1079-1092.
14 +
Laragh JH, Case DB, Atlas SA, et al:  Captopril compared with other antirenin system agents in hypertensive patients: Its triphasic effects on blood pressure and its use to identify and treat the renin factor . Hypertension 1980;; 2:586-593.
15 +
Bravo EL, Tarazi RC, Dustan HP, et al:  Dissociation between renin and arterial pressure responses to beta adrenergic blockade in human essential hypertension . Circ Res 1975;;36-37( (suppl 1) ):241-247.
16 +
 Propranolol in the treatment of essential hypertension, Veterans Administration Cooperative Study Group on Antihypertensive Agents . JAMA 1977;;237:2303-2310.
17 +
Tarazi RC, Bravo EL, Fouad FM, et al:  Hemodynamic and volume changes associated with captopril . Hypertension 1980;;2:576-585.
18 +
Swartz SL, Williams GH, Hollenberg NK, et al:  Captopril-induced changes in prostaglandin production . J Clin Invest 1980;;65:1257-1264.
19 +
Michelakis AM, McAllister RG:  Effect of chronic adrenergic receptor blockade on plasma renin activity in man . J Clin Endocrinol 1972;; 34:386-394.
20 +
Captopril:  Benefits and risks in severe hypertension , editorial. Lancet 1980;;2:129-130.

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