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ARTICLE |

Cholesterol, Coronary Disease, and Cancer FREE

Richard J. Jones, MD
JAMA. 1981;245(20):2060-2060. doi:10.1001/jama.1981.03310450052025
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In their important controlled trial that examined the use of a high polyunsaturated fat diet for the prevention of atherosclerotic complications in Los Angeles veterans, Dayton and co-workers1 reported a successful reduction in serum cholesterol levels and in fatal atherosclerotic complications. However, because of a compensatory increase in fatal cancers in the treatment group, there was no significant difference in overall mortality between the control and treatment groups. This finding was somewhat discouraging to those who hoped for a dietary solution to the atherosclerosis problem. However, it was pointed out that these men were old (average age, 67 years), and the competing mortality from cancer might be expected to compensate for the diminished atherosclerotic mortality. However, later, more careful review of the deaths showed a greater occurrence of both respiratory and gastrointestinal malignant neoplasms in the treatment group as opposed to that in the controls.2

In a recent

REFERENCES

Dayton S. Pearce ML. Hashimoto S. et al:  A controlled chemical trial of a diet high in unsaturated fat in preventing complications of atherosclerosis . Circulation 1967;;39-40( (suppl 2) ): 1-63.
Pearce ML, Dayton S:  Incidence of cancer in men on a diet high in polyunsaturated fat . Lancet 1971;;1:464-467.
Williams RR, Sorlie PD, Feinleib M. et al:  Cancer incidence by levels of cholesterol . JAMA 1981;;245:247-252.
 A cooperative trial in the primary prevention of ischemic heart disease, using clofibrate, Committee of Principal Investigators . Br Heart J 1978;;40:1069-1118.
Turpenien O:  Effect of cholesterol lowering diet on mortality from heart disease and other causes . Circulation 1979;;59:1-7.
Ederer F. Leren P. Turpenien O. et al:  Cancer among men on cholesterol lowering diets. Experience from five clinical trials . Lancet 1971;;2:203-206.
Carroll KK:  Experimental evidence of dietary factors and hormone-dependent cancers . Cancer Res 1975;;35:3374-3383.

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Dayton S. Pearce ML. Hashimoto S. et al:  A controlled chemical trial of a diet high in unsaturated fat in preventing complications of atherosclerosis . Circulation 1967;;39-40( (suppl 2) ): 1-63.
Pearce ML, Dayton S:  Incidence of cancer in men on a diet high in polyunsaturated fat . Lancet 1971;;1:464-467.
Williams RR, Sorlie PD, Feinleib M. et al:  Cancer incidence by levels of cholesterol . JAMA 1981;;245:247-252.
 A cooperative trial in the primary prevention of ischemic heart disease, using clofibrate, Committee of Principal Investigators . Br Heart J 1978;;40:1069-1118.
Turpenien O:  Effect of cholesterol lowering diet on mortality from heart disease and other causes . Circulation 1979;;59:1-7.
Ederer F. Leren P. Turpenien O. et al:  Cancer among men on cholesterol lowering diets. Experience from five clinical trials . Lancet 1971;;2:203-206.
Carroll KK:  Experimental evidence of dietary factors and hormone-dependent cancers . Cancer Res 1975;;35:3374-3383.
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To understand the clinical management of acute heart failure syndromes.
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