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May 1, 1981, Vol 245, No. 17 >
ARTICLE | May 1, 1981

Alcohol Consumption in a Healthy Population: Title and subTitle BreakRelationship to γ-Glutamyl Transferase Activity and Mean Corpuscular Volume FREE

Laure Papoz, MS; Jean-M. Warnet, PhD; Georges Péquignot, MD; Eveline Eschwege, MD; Jean R. Claude, PhD; Daniel Schwartz, PhD
[+] Author Affiliations

Reprint requests to Unité de Recherches Statistiques, INSERM, 16 bis av. Paul Vaillant Couturier, 94800 Villejuif, France (Dr Schwartz).


JAMA. 1981;245(17):1748-1751. doi:10.1001/jama.1981.03310420038027
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References

We analyzed the multivariate relationship between alcohol consumption and γ-glutamyl-transferase (GGT), mean corpuscular volume (MCV), and tobacco consumption. A group of 995 healthy outpatients (604 men and 391 women, 18 to 76 years old) were systematically examined. Daily alcohol consumption was established after an interview regarding complete dietary habits. Significant correlations have been found between daily alcohol intake and corresponding GGT and MCV values, 35 and 34, respectively, in men and 24 and 21 in women. Multiple regression analyses confirm the superiority of GGT over MCV as a laboratory marker of alcohol intake and show the advantage of using them together. A rough estimation of alcohol consumption is proposed as a first step in mass screening of heavy drinkers.

(JAMA 1981;245:1748-1751)

REFERENCES

1 +
Szasz G:  A kinetic photometric method for serum gamma-glutamyl-transpeptidase . Clin Chem 1969;;15:124-136.
2 +
Rosalki SA, Rau D:  Serum gamma-glutamyl-transpeptidase activity in alcoholism . Clin Chim Acta 1972;;39:41-47.
3 +
Lamy J, Weill J, Aron E:  Dépistage précoce et surveillance de la consommation excessive d'alcool par la mesure de l'activité de la gammaglutamyl-transpeptidase sérique . Rev Alc 1974;; 20:1-22.
4 +
Wu A, Chanarin I, Levi AJ:  Macrocytosis of chronic alcoholism . Lancet 1974;;1:829-830.
5 +
Unger KW, Johnson D Jr:  Red blood cell mean corpuscular volume: A potential indicator of alcohol usage in a working population . Am J Med Sci 1974;;267:281-289.
6 +
Chaput JC, Lecomte MV, Poynard T, et al:  Relation entre le volume globulaire moyen, les consommations alcooliques et tabagiques et l'existence des maladies alcooliques du foie chez des malades hospitalisés . Gastroenterol Clin Biol 1979;;3:221-226.
7 +
Baglin MC, Bernot JL, Bremond JL, et al:  Efficacité comparée du volume globulaire moyen et de la gamma-glutamyl-transferase sérique comme tests de triage des buveurs excessifs d'alcool . Clin Chim Acta 1976;;68:321-326.
8 +
Fontan M, Goudemand M, Caridroit M, et al:  Dépistage biologique de l'alcoolisme chronique . Nouv Presse Med 1978;;7:469.
9 +
Whitehead TP, Clarke CA, Whitfield AGW:  Biochemical and haematological marker of alcohol intake . Lancet 1978;;1:978-981.
10 +
Bagrel A, d'Houtaud A, Gueguen R, et al:  Relations between reported alcohol consumption and certain biological variables in an unselected population . Clin Chem 1979;;25:1242-1246.
11 +
Eschwege E, Papoz L, Lellouch J, et al:  Blood cells and alcohol consumption with special reference to smoking habits . J Clin Pathol 1978;;31:654-658.
12 +
Pequignot G, Cubeau J:  Methodological surveys comparing, in the same individuals, the food consumption as estimated by questioning with the food consumption as measured by weighing the aliments . Rev Epidemiol Sante Publique 1973;;21:585-593.
13 +
Morgan RW, Jain M, Miller AB, et al:  A comparison of dietary methods in epidemiologic studies . Am J Epidemiol 1978;;107:488-498.
14 +
Rosalki SB:  Plasma enzyme changes and their interpretation in patients receiving anticonvulsant and enzyme inducing drugs, in study group 9 of the IRMMH : Anticonvulsant Drugs and Enzyme Induction . Amsterdam, Elsevier Publishing Co, 1976;, pp 27-35.
15 +
Schiele F, Guilmin AM, Detienne H, et al:  Gamma-glutamyl-transferase activity in plasma: Statistical distribution, individual variations and reference intervals . Clin Chem 1977;; 23:1023-1028.
16 +
Rosalki SB, Rau D, Lehmann D, et al:  Determination of serum γ-glutamyl transpeptidase activity and its clinical applications . Ann Clin Biochem 1970;;7:143-147.
17 +
Warnet JM, Papoz L, Bonnaud G, et al:  Multiple regression analysis on alcohol consumption, gamma-glutamyl transferase and mean corpuscular volume in 995 healthy subjects , in Proceedings of the International Symposium on Metabolic Effects of Alcohol . New York, Elsevier/North-Holland Biomedical Press, 1979;.

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1 +
Szasz G:  A kinetic photometric method for serum gamma-glutamyl-transpeptidase . Clin Chem 1969;;15:124-136.
2 +
Rosalki SA, Rau D:  Serum gamma-glutamyl-transpeptidase activity in alcoholism . Clin Chim Acta 1972;;39:41-47.
3 +
Lamy J, Weill J, Aron E:  Dépistage précoce et surveillance de la consommation excessive d'alcool par la mesure de l'activité de la gammaglutamyl-transpeptidase sérique . Rev Alc 1974;; 20:1-22.
4 +
Wu A, Chanarin I, Levi AJ:  Macrocytosis of chronic alcoholism . Lancet 1974;;1:829-830.
5 +
Unger KW, Johnson D Jr:  Red blood cell mean corpuscular volume: A potential indicator of alcohol usage in a working population . Am J Med Sci 1974;;267:281-289.
6 +
Chaput JC, Lecomte MV, Poynard T, et al:  Relation entre le volume globulaire moyen, les consommations alcooliques et tabagiques et l'existence des maladies alcooliques du foie chez des malades hospitalisés . Gastroenterol Clin Biol 1979;;3:221-226.
7 +
Baglin MC, Bernot JL, Bremond JL, et al:  Efficacité comparée du volume globulaire moyen et de la gamma-glutamyl-transferase sérique comme tests de triage des buveurs excessifs d'alcool . Clin Chim Acta 1976;;68:321-326.
8 +
Fontan M, Goudemand M, Caridroit M, et al:  Dépistage biologique de l'alcoolisme chronique . Nouv Presse Med 1978;;7:469.
9 +
Whitehead TP, Clarke CA, Whitfield AGW:  Biochemical and haematological marker of alcohol intake . Lancet 1978;;1:978-981.
10 +
Bagrel A, d'Houtaud A, Gueguen R, et al:  Relations between reported alcohol consumption and certain biological variables in an unselected population . Clin Chem 1979;;25:1242-1246.
11 +
Eschwege E, Papoz L, Lellouch J, et al:  Blood cells and alcohol consumption with special reference to smoking habits . J Clin Pathol 1978;;31:654-658.
12 +
Pequignot G, Cubeau J:  Methodological surveys comparing, in the same individuals, the food consumption as estimated by questioning with the food consumption as measured by weighing the aliments . Rev Epidemiol Sante Publique 1973;;21:585-593.
13 +
Morgan RW, Jain M, Miller AB, et al:  A comparison of dietary methods in epidemiologic studies . Am J Epidemiol 1978;;107:488-498.
14 +
Rosalki SB:  Plasma enzyme changes and their interpretation in patients receiving anticonvulsant and enzyme inducing drugs, in study group 9 of the IRMMH : Anticonvulsant Drugs and Enzyme Induction . Amsterdam, Elsevier Publishing Co, 1976;, pp 27-35.
15 +
Schiele F, Guilmin AM, Detienne H, et al:  Gamma-glutamyl-transferase activity in plasma: Statistical distribution, individual variations and reference intervals . Clin Chem 1977;; 23:1023-1028.
16 +
Rosalki SB, Rau D, Lehmann D, et al:  Determination of serum γ-glutamyl transpeptidase activity and its clinical applications . Ann Clin Biochem 1970;;7:143-147.
17 +
Warnet JM, Papoz L, Bonnaud G, et al:  Multiple regression analysis on alcohol consumption, gamma-glutamyl transferase and mean corpuscular volume in 995 healthy subjects , in Proceedings of the International Symposium on Metabolic Effects of Alcohol . New York, Elsevier/North-Holland Biomedical Press, 1979;.

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