Allogeneic Bone Marrow Transplantation for 144 Patients With Severe Aplastic Anemia FREE

Mortimer M. Bortin, MD; Robert P. Gale, MD, PhD; Alfred A. Rimm, PhD

[+] Author Affiliations

Eleventh report from the International Bone Marrow Transplant Registry, Milwaukee.

Reprint requests to International Bone Marrow Transplant Registry, 950 N 12th St, Milwaukee, WI 53233 (Dr Bortin).

JAMA. 1981;245(11):1132-1139. doi:10.1001/jama.1981.03310360024017

Text Size: A A A

This article was corrected | View correction

Published online

Article

References

ABSTRACT

ABSTRACT | REFERENCES

Comprehensive data were reported to the International Bone Marrow Transplant Registry by 24 worldwide teams regarding 144 patients with severe aplastic anemia who were treated with HLA-identical, allogeneic bone marrow transplantation between 1975 and 1978. One hundred fourteen patients received one transplant and 30 received two. Sustained engraftment of donor marrow occurred on the first transplant attempt in 76% of the patients whose engraftment status could be evaluated. Moderate, severe, or lethal graft-vs-host disease (GVHD) occurred in 52% of the engrafted patients. The one-year survival rate for all patients was 44% (64/144). Among the one-year survivors, the primary disease was apparently cured in 90% and improved in 10%. Thus far, four patients died one to five years after transplant. Of the 60 patients currently alive, ten have chronic GVHD and the remainder are in good health. Multivariate analyses of the data disclosed a number of pretransplant factors associated with engraftment, GVHD, and one-year survival. The most important finding was that the use of male donors was preferable to female donors because of a higher rate of engraftment, less severe GVHD, and a higher one-year survival rate.

(JAMA 1981;245:1132-1139)

REFERENCES

ABSTRACT | REFERENCES

Bortin MM, Rimm AA: Bone marrow transplantation from histocompatible, allogeneic donors for aplastic anemia, Advisory Committee of the International Bone Marrow Transplant Registry . JAMA 1976;;236:1131-1135.

Storb R, and the Seattle Bone Marrow Transplant Team: Immunologic and hematologic concepts as they relate to aplastic anemia . Transplant Proc 1979;;11:1916-1919.

Camitta BM, Thomas ED, Nathan DG, et al: A prospective study of androgens and bone marrow transplantation for treatment of severe aplastic anemia . Blood 1979;;53:504-514.

Gale RP, Feig SA, Ho W, et al: Prevention of graft rejection following bone marrow transplantation . Blood , to be published.

Advisory Committee of the Bone Marrow Transplant Registry: A report from the ACS/ NIH bone marrow transplant registry . Exp Hematol 1975;;3:149-155.

Cutler SJ, Ederer F: Maximum utilization of the life table method in analyzing survival . J Chronic Dis 1958;;8:699-712.

Gehan EA: A generalized Wilcoxon test for comparing arbitrarily censored samples . Biometrika 1965;;52:203-223.

Walker SH, Duncan DB: Estimation of the probability of an event as a function of several independent variables . Biometrika 1967;;54:167-179.

Snedecor GW, Cochran WG: Statistical Methods , ed 6. Ames, Iowa, Iowa State University Press, 1976;, pp 383-412.

Bortin MM, Rimm AA, for the Advisory Committee of the International Bone Marrow Transplant Registry: Severe combined immunodeficiency disease: Characterization of the disease and results of transplantation . JAMA 1977;;238:591-600.

Bortin MM, Rimm AA, for the Advisory Committee of the International Bone Marrow Transplant Registry: Bone marrow transplantation for acute myeloblastic leukemia . JAMA 1978;;240:1245-1252.

Thomas ED, Buckner DC, Banaji M, et al: One hundred patients with acute leukemia treated by chemotherapy, total body irradiation and allogeneic marrow transplantation . Blood 1977;;49:511-532.

Storb R, Thomas ED, Buckner CD, et al: Allogeneic marrow grafting for treatment of aplastic anemia: A follow-up on long-term survivors . Blood 1976;;48:485-490.

Neiman PE, Reeues W, Ray G, et al: A prospective analysis of interstitial pneumonia and opportunistic viral infection among recipients of allogeneic marrow grafts . J Infect Dis 1977;;136:754-767.

Storb R, Prentice RL, Thomas ED: Marrow transplantation for treatment of aplastic anemia: An analysis of factors associated with graft rejection . N Engl J Med 1977;;296:61-66.

Storb R, Prentice RL, Thomas ED: Treatment of aplastic anemia by marrow transplantation from HL-A identical siblings: Prognostic factors associated with graft versus host disease and survival . J Clin Invest 1977;;59:625-632.

Eidenger D, Garrett TJ: Studies of the regulating effects of the sex hormones on antibody formation and stem cell differentiation . J Exp Med 1972;;136:1098-1116.

Storb R, Thomas ED, Buckner DC, et al: Marrow transplantation in thirty 'untransfused' patients with severe aplastic anemia . Ann Intern Med 1980;;92:30-36.

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal