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January 2, 1981, Vol 245, No. 1 >
ARTICLE | January 2, 1981

Single-Nutrient Effects on Immunologic Functions: Title and subTitle BreakReport of a Workshop Sponsored by the Department of Food and Nutrition and Its Nutrition Advisory Group of the American Medical Association FREE

William R. Beisel, MD; Robert Edelman, MD; Kathleen Nauss, PhD; Robert M. Suskind, MD
[+] Author Affiliations

A complete list of publications assembled by workshop participants is available from the Department of Foods and Nutrition, American Medical Association, 535 N Dearborn St, Chicago, IL 60610 (Margarita Nagy).

Reprint requests to Department of Foods and Nutrition, American Medical Association, 535 N Dearborn St, Chicago, IL 60610 (Margarita Nagy).


JAMA. 1981;245(1):53-58. doi:10.1001/jama.1981.03310260031024
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References

Immune system dysfunction can result from single-nutrient deficiencies or excesses, alone or in combination with generalized protein-energy malnutrition. Acquired immune dysfunctions in man occur with deficiencies of iron, zinc, vitamins A and B12, pyridoxine, and folic acid and with excesses of essential fatty acids and vitamin E. Additional micronutrients are important for maintaining immunologic competence in animals. Deficits or excesses of many trace elements and single nutrients thus have potential for causing immune dysfunctions in man. Since nutritionally induced immune dysfunction is generally reversible, it is important to recognize and identify clinical illnesses in which immunologic dysfunctions are of nutritional origin. Correction of malnutrition should lead to prompt reversal of acquired immune dysfunctions.

(JAMA 1981;245:53-58)

REFERENCES

1 +
Dreizen S:  Nutrition and the immune response—a review . Int J Vitam Nutr Res 1978;; 49:220-228.
2 +
Beisel WR:  Malnutrition and the immune response , in Neuberger A, Jukes TH (eds): Biochemistry of Nutrition I . Baltimore, University Park Press, 1979;, pp 1-19.
3 +
Edelman R:  Cell-mediated immune response in protein-calorie malnutrition—a review , in Suskind RM (ed): Malnutrition and the Immune Response . New York, Raven Press, 1977;, pp 47-75.
4 +
Axelrod AE:  Immune processses in vitamin deficiency states . Am J Clin Nutr 1971;;24:265-271.
5 +
Hodges RE, Bean WB, Ohlson MA, et al:  Factors affecting human antibody response: V. Combined deficiencies of pantothenic acid and pyridoxine . Am J Clin Nutr 1962;;11:187-199.
6 +
Thomas WR, Holt PG:  Vitamin C and immunity: An assessment of the evidence . Clin Exp Immunol 1978;;32:370-379.
7 +
Boxer LA, Watanabe AM, Bister M, et al:  Correction of leukocyte function in Chediak-Higashi syndrome by ascorbate . N Engl J Med 1976;;295:1041-1045.
8 +
Nockels CF:  Protective effects of supplemental vitamin E against infection . Fed Proc 1979;;38:2134-2138.
9 +
Prasad JS:  Effect of vitamin E supplementation on leukocyte function . Am J Clin Nutr 1980;;33:606-608.
10 +
Chandra RK, Au B, Woodford G, et al:  Iron status, immune response and susceptibility to infection , in Kies H (ed), Iron Metabolism, Ciba Foundation symposium 51 . Amsterdam, Elsevier/Excerpta Medica/North-Holland, 1977;, pp 249-268.
11 +
Buckley RH:  Iron deficiency anemia: Its relationship to infection susceptibility and host defense . J Pediatr 1975;;86:993-995.
12 +
Murray MJ, Murray AB, Murray MB, et al:  The adverse effect of iron repletion on the course of certain infections . Br Med J 1978;;2:1113-1115.
13 +
Golden HN, Golden BE, Harland PSEG, et al:  Zinc and immunocompetence in protein-energy malnutrition . Lancet 1978;;1:1226-1228.
14 +
Bois P:  Effect of magnesium deficiency on mast cells and urinary histamine in rats . Br J Exp Pathol 1963;;44:151-155.
15 +
McHugh MI, Wilkinson R, Elliott RW, et al:  Immunosuppression with polyunsaturated fatty acids in renal transplantation . Transplantation , 1977;;24:263-267.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

1 +
Dreizen S:  Nutrition and the immune response—a review . Int J Vitam Nutr Res 1978;; 49:220-228.
2 +
Beisel WR:  Malnutrition and the immune response , in Neuberger A, Jukes TH (eds): Biochemistry of Nutrition I . Baltimore, University Park Press, 1979;, pp 1-19.
3 +
Edelman R:  Cell-mediated immune response in protein-calorie malnutrition—a review , in Suskind RM (ed): Malnutrition and the Immune Response . New York, Raven Press, 1977;, pp 47-75.
4 +
Axelrod AE:  Immune processses in vitamin deficiency states . Am J Clin Nutr 1971;;24:265-271.
5 +
Hodges RE, Bean WB, Ohlson MA, et al:  Factors affecting human antibody response: V. Combined deficiencies of pantothenic acid and pyridoxine . Am J Clin Nutr 1962;;11:187-199.
6 +
Thomas WR, Holt PG:  Vitamin C and immunity: An assessment of the evidence . Clin Exp Immunol 1978;;32:370-379.
7 +
Boxer LA, Watanabe AM, Bister M, et al:  Correction of leukocyte function in Chediak-Higashi syndrome by ascorbate . N Engl J Med 1976;;295:1041-1045.
8 +
Nockels CF:  Protective effects of supplemental vitamin E against infection . Fed Proc 1979;;38:2134-2138.
9 +
Prasad JS:  Effect of vitamin E supplementation on leukocyte function . Am J Clin Nutr 1980;;33:606-608.
10 +
Chandra RK, Au B, Woodford G, et al:  Iron status, immune response and susceptibility to infection , in Kies H (ed), Iron Metabolism, Ciba Foundation symposium 51 . Amsterdam, Elsevier/Excerpta Medica/North-Holland, 1977;, pp 249-268.
11 +
Buckley RH:  Iron deficiency anemia: Its relationship to infection susceptibility and host defense . J Pediatr 1975;;86:993-995.
12 +
Murray MJ, Murray AB, Murray MB, et al:  The adverse effect of iron repletion on the course of certain infections . Br Med J 1978;;2:1113-1115.
13 +
Golden HN, Golden BE, Harland PSEG, et al:  Zinc and immunocompetence in protein-energy malnutrition . Lancet 1978;;1:1226-1228.
14 +
Bois P:  Effect of magnesium deficiency on mast cells and urinary histamine in rats . Br J Exp Pathol 1963;;44:151-155.
15 +
McHugh MI, Wilkinson R, Elliott RW, et al:  Immunosuppression with polyunsaturated fatty acids in renal transplantation . Transplantation , 1977;;24:263-267.

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