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August 22, 1980, Vol 244, No. 8 >
ARTICLE | August 22, 1980

Clinical Experience With a Human Diploid Cell Rabies Vaccine FREE

Larry J. Anderson, MD; William G. Winkler, DVM; Barry Hafkin, MD; Richard A. Keenlyside, MBBS; Lawrence J. D'Angelo, MD, MPH; Marc W. Deitch, MD
[+] Author Affiliations

Reprint requests to Viral Diseases Division, Bureau of Epidemiology, Center for Disease Control, Atlanta, GA 30333 (Dr Anderson).


JAMA. 1980;244(8):781-784. doi:10.1001/jama.1980.03310080015015
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References

Between January 1975 and December 1977 the Center for Disease Control treated 255 persons with the human diploid cell strain rabies vaccine who did not have development of an antibody titer to duck embryo vaccine (DEV) or who were at risk for having a serious reaction to DEV. Two hundred eighteen persons were treated postexposure, and 37 persons were treated preexposure. The antibody response to the vaccine was excellent, and the reaction rates were low. No person treated has had development of rabies. This study corroborates other studies that suggest that the human diploid cell strain rabies vaccines are safe and induce excellent antibody titers to rabies.

(JAMA 244:781-784, 1980)

REFERENCES

1 +
Wiktor TJ, Plotkin SA, Koprowski H:  Development and clinical trials of the new human rabies vaccine of tissue culture (human diploid cell) origin . Dev Biol Stand 40:3-9, 1978;.
2 +
Kuwert EK, Marcus I, Hoher PG:  Neutralizing and complement-fixing antibody responses in pre- and post-exposure vacciness to a rabies vaccine produced in human diploid cells . J Biol Stand 4:249-262, 1976;.
3 +
Shah U, Jaswal GS, Mansharamani HJ, et al:  Trial of human diploid cell rabies vaccine in human volunteers . Br Med J 1:997-998, 1976;.
4 +
Aoki FY, Tyrrell DAJ, Hill LE, et al:  Immunogenicity and acceptability of a human diploid-cell culture rabies vaccine in volunteers . Lancet 1:660-662, 1975;.
5 +
Turner GS, Aoki FY, Tyrrell DAJ, et al:  Human diploid cell strain rabies vaccine: Rapid prophylactic immunization of volunteers with small doses . Lancet 1:1379-1381, 1976;.
6 +
Cox JH, Schneider LG:  Prophylactic immunization of humans against rabies by intradermal inoculation of human diploid cell culture vaccine . J Clin Microbiol 3:96-101, 1976;.
7 +
Nicholson KG, Turner GS, Aoki FY:  Immunization with a human diploid cell strain of rabies virus vaccine: Two year results . J Infect Dis 137:783-788, 1978;.
8 +
Bahmanyar M, Fayza A, Nour-Salehi S, et al:  Successful protection of humans exposed to rabies infection: Postexposure treatment with the new human diploid cell rabies vaccine and antirabies serum . JAMA 236:2751-2754, 1976;.
9 +
Kuwert EK, Marcus I, Werner J, et al:  Post-exposure use of human diploid cell culture rabies vaccine . Dev Biol Stand 37:273-286, 1977;.
10 +
Plotkin SA, Wiktor TJ, Koprowski H, et al:  Immunization schedules for the new human diploid cell vaccine against rabies . Am J Epidemiol 103:75-80, 1976;.
11 +
Garner WR, Jones DO: Pratt E:  Problems associated with rabies preexposure prophylaxis . JAMA 235:1131-1132, 1976;.
12 +
Cabasso VJ, Dobkin MB, Roby RE, et al:  Antibody response to a human diploid cell rabies vaccine . Appl Microbiol 27:553-561, 1974;.
13 +
Wiktor TJ, Plotkin SA, Grella DW:  Human cell culture rabies vaccine: Antibody response in man . JAMA 224:1170-1171, 1973;.
14 +
Hafkin B, Hattwick MAW, Smith JS, et al:  A comparison of a WI-38 vaccine and duck embryo vaccine for preexposure rabies prophylaxis . Am J Epidemiol 107:439-443, 1978;.
15 +
Hafkin B, Alls ME, Baer GM:  Human rabies globulin and human diploid vaccine dose determinations . Dev Biol Stand 40:121-127, 1978;.
16 +
Anderson LJ, Winkler WG:  The Center for Diseases Control's experience with a human diploid rabies vaccine , in Program and Abstracts of 19th Interscience Conference on Antimicrobial Agents and Chemotherapy, Oct 1-5, 1979 . Boston, American Society for Microbiology, 1979;, p 475.
17 +
Plotkin SA, Wiktor T:  Vaccination of children with human cell culture rabies vaccine . Pediatrics 63:219-221, 1979;.
18 +
Tint H, Dobkin MB, Rubin BA:  A new tissue culture (WI-38) rabies vaccine, inactivated and disaggregated with tri-N-butyl phosphate . Symp Ser Immunobiol Stand 21:132-144, 1974;.
19 +
Tint H, Rosanoff EI:  Potency testing of diploid-cell rabies vaccine and correlation with immunogenicity . Dev Biol Stand 40:195-201, 1978;.
20 +
Smith JS, Yager PA, Baer GM:  A rapid reproducible test for determining rabies neutralizing antibody . Bull WHO 48:535-541, 1973;.
21 +
Reed LJ, Muench H:  A simple method of estimating 50% endpoints . Am J Hyg 27:493-497, 1938;.
22 +
Tint H, Rosanoff EI:  Clinical responses to T(N)BP-disrupted HDCS (WI-38) rabies vaccine . Dev Biol Stand 37:287-289, 1977;.
23 +
Corey L, Hattwick MAW, Baer GM, et al:  Serum neutralizing antibody after rabies postexposure prophylaxis . Ann Intern Med 85:170-176, 1976;.
24 +
Hattwick MAW, Rubin RH, Music S, et al:  Postexposure rabies prophylaxis with human rabies immune globulin . JAMA 227:407-410, 1974;.
25 +
Hattwick MAW, Gregg MB:  The disease in man , in Baer GM (ed): The Natural History of Rabies . New York, Academic Press Inc, 1973;, pp 141-152.
26 +
Veerarghaven N: Annual Report of the Director 1969 and Scientific Report 1970 . Coonoor, India, Pasteur Institute of Southern India, 1971;, pp 38-44.
27 +
Schoop HD:  Indikationsstellung fur die Tollwutshutzbehandlung . Zentralbl Bakteriol Orig 3( (suppl) ):57-75, 1970;.
28 +
Sikes RK, Peacock GV, Acha P, et al:  Rabies vaccines: Duration of immunity study in dogs . J Am Vet Med Assoc 159:1491-1499, 1971;.
29 +
Strating A, Bunn TO, Goff MT, et al:  Efficacy of inactivated tissue culture rabies vaccine in dogs . J Am Vet Med Assoc 167:809-812, 1975;.
30 +
Cabasso VJ, Sharpless GR, Douglas A:  Rabies vaccination of cats with HEP flury vaccine . Am J Vet Res 26:33-38, 1965;.
31 +
 Vaccine potency requirements for reduced immunization schedules and preexposure treatment, Working Group 2 . Dev Biol Stand 40:268-270, 1978;.

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1 +
Wiktor TJ, Plotkin SA, Koprowski H:  Development and clinical trials of the new human rabies vaccine of tissue culture (human diploid cell) origin . Dev Biol Stand 40:3-9, 1978;.
2 +
Kuwert EK, Marcus I, Hoher PG:  Neutralizing and complement-fixing antibody responses in pre- and post-exposure vacciness to a rabies vaccine produced in human diploid cells . J Biol Stand 4:249-262, 1976;.
3 +
Shah U, Jaswal GS, Mansharamani HJ, et al:  Trial of human diploid cell rabies vaccine in human volunteers . Br Med J 1:997-998, 1976;.
4 +
Aoki FY, Tyrrell DAJ, Hill LE, et al:  Immunogenicity and acceptability of a human diploid-cell culture rabies vaccine in volunteers . Lancet 1:660-662, 1975;.
5 +
Turner GS, Aoki FY, Tyrrell DAJ, et al:  Human diploid cell strain rabies vaccine: Rapid prophylactic immunization of volunteers with small doses . Lancet 1:1379-1381, 1976;.
6 +
Cox JH, Schneider LG:  Prophylactic immunization of humans against rabies by intradermal inoculation of human diploid cell culture vaccine . J Clin Microbiol 3:96-101, 1976;.
7 +
Nicholson KG, Turner GS, Aoki FY:  Immunization with a human diploid cell strain of rabies virus vaccine: Two year results . J Infect Dis 137:783-788, 1978;.
8 +
Bahmanyar M, Fayza A, Nour-Salehi S, et al:  Successful protection of humans exposed to rabies infection: Postexposure treatment with the new human diploid cell rabies vaccine and antirabies serum . JAMA 236:2751-2754, 1976;.
9 +
Kuwert EK, Marcus I, Werner J, et al:  Post-exposure use of human diploid cell culture rabies vaccine . Dev Biol Stand 37:273-286, 1977;.
10 +
Plotkin SA, Wiktor TJ, Koprowski H, et al:  Immunization schedules for the new human diploid cell vaccine against rabies . Am J Epidemiol 103:75-80, 1976;.
11 +
Garner WR, Jones DO: Pratt E:  Problems associated with rabies preexposure prophylaxis . JAMA 235:1131-1132, 1976;.
12 +
Cabasso VJ, Dobkin MB, Roby RE, et al:  Antibody response to a human diploid cell rabies vaccine . Appl Microbiol 27:553-561, 1974;.
13 +
Wiktor TJ, Plotkin SA, Grella DW:  Human cell culture rabies vaccine: Antibody response in man . JAMA 224:1170-1171, 1973;.
14 +
Hafkin B, Hattwick MAW, Smith JS, et al:  A comparison of a WI-38 vaccine and duck embryo vaccine for preexposure rabies prophylaxis . Am J Epidemiol 107:439-443, 1978;.
15 +
Hafkin B, Alls ME, Baer GM:  Human rabies globulin and human diploid vaccine dose determinations . Dev Biol Stand 40:121-127, 1978;.
16 +
Anderson LJ, Winkler WG:  The Center for Diseases Control's experience with a human diploid rabies vaccine , in Program and Abstracts of 19th Interscience Conference on Antimicrobial Agents and Chemotherapy, Oct 1-5, 1979 . Boston, American Society for Microbiology, 1979;, p 475.
17 +
Plotkin SA, Wiktor T:  Vaccination of children with human cell culture rabies vaccine . Pediatrics 63:219-221, 1979;.
18 +
Tint H, Dobkin MB, Rubin BA:  A new tissue culture (WI-38) rabies vaccine, inactivated and disaggregated with tri-N-butyl phosphate . Symp Ser Immunobiol Stand 21:132-144, 1974;.
19 +
Tint H, Rosanoff EI:  Potency testing of diploid-cell rabies vaccine and correlation with immunogenicity . Dev Biol Stand 40:195-201, 1978;.
20 +
Smith JS, Yager PA, Baer GM:  A rapid reproducible test for determining rabies neutralizing antibody . Bull WHO 48:535-541, 1973;.
21 +
Reed LJ, Muench H:  A simple method of estimating 50% endpoints . Am J Hyg 27:493-497, 1938;.
22 +
Tint H, Rosanoff EI:  Clinical responses to T(N)BP-disrupted HDCS (WI-38) rabies vaccine . Dev Biol Stand 37:287-289, 1977;.
23 +
Corey L, Hattwick MAW, Baer GM, et al:  Serum neutralizing antibody after rabies postexposure prophylaxis . Ann Intern Med 85:170-176, 1976;.
24 +
Hattwick MAW, Rubin RH, Music S, et al:  Postexposure rabies prophylaxis with human rabies immune globulin . JAMA 227:407-410, 1974;.
25 +
Hattwick MAW, Gregg MB:  The disease in man , in Baer GM (ed): The Natural History of Rabies . New York, Academic Press Inc, 1973;, pp 141-152.
26 +
Veerarghaven N: Annual Report of the Director 1969 and Scientific Report 1970 . Coonoor, India, Pasteur Institute of Southern India, 1971;, pp 38-44.
27 +
Schoop HD:  Indikationsstellung fur die Tollwutshutzbehandlung . Zentralbl Bakteriol Orig 3( (suppl) ):57-75, 1970;.
28 +
Sikes RK, Peacock GV, Acha P, et al:  Rabies vaccines: Duration of immunity study in dogs . J Am Vet Med Assoc 159:1491-1499, 1971;.
29 +
Strating A, Bunn TO, Goff MT, et al:  Efficacy of inactivated tissue culture rabies vaccine in dogs . J Am Vet Med Assoc 167:809-812, 1975;.
30 +
Cabasso VJ, Sharpless GR, Douglas A:  Rabies vaccination of cats with HEP flury vaccine . Am J Vet Res 26:33-38, 1965;.
31 +
 Vaccine potency requirements for reduced immunization schedules and preexposure treatment, Working Group 2 . Dev Biol Stand 40:268-270, 1978;.

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