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November 7, 1980, Vol 244, No. 18 >
ARTICLE | November 7, 1980

Prevalence and Site-Pathogen Studies of Neisseria meningitidis and N gonorrhoeae in Homosexual Men FREE

William M. Janda, PhD; Marjorie Bohnhoff, MS; Josephine A. Morello, PhD; Stephen A. Lerner, MD
[+] Author Affiliations

Reprint requests to University of Chicago School of Medicine, Box 415, 950 E 59th St, Chicago, IL 60637 (Dr Lerner).


JAMA. 1980;244(18):2060-2064. doi:10.1001/jama.1980.03310180026026
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References

Prevalence and site-pathogen studies of pathogenic Neisseria were conducted in 815 homosexual men over a 12-month period. Neisseria meningitidis was isolated from more patients than N gonorrhoeae (43.1% vs 33.1%). A high oropharyngeal carriage of N meningitidis (42.5%) was present, with much lower urethral (0.7%) and rectal (2.0%) colonization. Although N meningitidis urethral isolates were associated with urethral discharge in five of six patients, N meningitidis in the oropharynx or rectum was not usually associated with clinical illness. Neisseria meningitidis was usually isolated from only one site in individual patients. Neisseria gonorrhoeae was isolated from the urethra (18.5%), rectum (16.3%), and oropharynx (5.6%). Of the 270 patients with gonococcal infection, 49.1% had urethral gonorrhea only, and 20.7% were infected at two or more body sites. Virtually all patients with urethral infection had symptoms of urethritis, whereas 89.1% of patients with oropharyngeal infection and 61.9% of patients with anorectal infection had no local symptoms.

(JAMA 244:2060-2064, 1980)

REFERENCES

1 +
Felman GM, Morrison JM:  Examining the homosexual male for sexually transmitted diseases . JAMA 238:2046-2047, 1977;.
2 +
Ostrow DG, Shaskey DM:  The experience of the Howard Brown Memorial Clinic of Chicago with sexually transmitted diseases . Sex Transm Dis 4:53-55, 1977;.
3 +
Morello JA, Graves MH, Lerner SA, et al:  Auxotypes and penicillin susceptibilities of Neisseria gonorrhoeae strains isolated from homosexual and heterosexual males  (abstract No. C-7), in Abstracts of the Annual Meeting of the American Society for Microbiology . Washington, DC, American Society for Microbiology, 1978;, p 278.
4 +
Bohnhoff M, Graves MH, Janda WM, et al:  Isolation of pathogenic Neisseria from the oropharynges of homosexual and heterosexual males  (abstract No. C-15), in Abstracts of the Annual Meeting of the American Society for Microbiology . Washington, DC, American Society for Microbiology, 1978;, p 279.
5 +
Morello JA, Lerner SA, Bohnhoff M:  Characteristics of atypical Neisseria gonorrhoeae from disseminated and localized infections . Infect Immun 13:1510-1516, 1976;.
6 +
Noble RC, Cooper RM, Miller BR:  Pharyngeal colonization by Neisseria gonorrhoeae and Neisseria meningitidis in black and white patients attending a venereal disease clinic . Br J Vener Dis 55:14-19, 1979;.
7 +
Willcox RR, Spencer RC, Ison C:  Which Neisseria? Br J Vener Dis 53:394-397, 1977;.
8 +
Young H, Harris AB, Robertson HH:  Individual susceptibility to neisserial infection? Br J Vener Dis 55:188-190, 1979;.
9 +
Goldmeier D, Darougar S:  Isolation of Chlamydia trachomatis from throat and rectum of homosexual men . Br J Vener Dis 53:184-185, 1977;.
10 +
Givan KF, Thomas DW, Johnston AG:  Isolation of Neisseria meningitidis from the urethra, cervix, and anal canal: Further observations . Br J Vener Dis 53:109-112, 1977;.
11 +
Judson FN, Ehret JM, Eickhoff TC:  Anogenital infection with Neisseria meningitidis in homosexual men . J Infect Dis 137:458-463, 1978;.
12 +
Merino HI, Richards JB:  An innovative program of venereal disease casefinding, treatment, and education for a population of gay men . Sex Transm Dis 4:50-52, 1977;.
13 +
Owen RL, Hill JL:  Rectal and pharyngeal gonorrhea in homosexual men . JAMA 220:1315-1318, 1972;.
14 +
McMillan A, Young H:  Gonorrhea in the homosexual man: Frequency of infection by culture site . Sex Transm Dis 5:146-150, 1978;.
15 +
Rein MF:  Epidemiology of gonococcal infections , in Roberts RB (ed): The Gonococcus . New York, John Wiley & Sons Inc, 1977;, pp 1-31.
16 +
Handsfield HH:  Clinical aspects of gonococcal infections , in Roberts RB (ed): The Gonococcus . New York, John Wiley & Sons Inc, 1977;, pp 57-79.
17 +
Knapp JS, Holmes KK:  Disseminated gonococcal infections caused by Neisseria gonorrhoeae with unique nutritional requirements . J Infect Dis 132:204-208, 1975;.
18 +
Crawford G, Knapp JS, Hale J, et al:  Asymptomatic gonorrhea in men: Caused by gonococci with unique nutritional requirements . Science 196:1352-1353, 1977;.
19 +
Knapp JS, Thornsberry C, Schoolnik GA, et al:  Phenotypic and epidemiologic correlates of auxotype in Neisseria gonorrhoeae . J Infect Dis 138:160-165, 1978;.
20 +
Volk J, Kraus SJ:  Asymptomatic meningococcal urethritis: Possible protective value against gonococcal infection by bacteriocin production . Br J Vener Dis 49:511-512, 1973;.

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1 +
Felman GM, Morrison JM:  Examining the homosexual male for sexually transmitted diseases . JAMA 238:2046-2047, 1977;.
2 +
Ostrow DG, Shaskey DM:  The experience of the Howard Brown Memorial Clinic of Chicago with sexually transmitted diseases . Sex Transm Dis 4:53-55, 1977;.
3 +
Morello JA, Graves MH, Lerner SA, et al:  Auxotypes and penicillin susceptibilities of Neisseria gonorrhoeae strains isolated from homosexual and heterosexual males  (abstract No. C-7), in Abstracts of the Annual Meeting of the American Society for Microbiology . Washington, DC, American Society for Microbiology, 1978;, p 278.
4 +
Bohnhoff M, Graves MH, Janda WM, et al:  Isolation of pathogenic Neisseria from the oropharynges of homosexual and heterosexual males  (abstract No. C-15), in Abstracts of the Annual Meeting of the American Society for Microbiology . Washington, DC, American Society for Microbiology, 1978;, p 279.
5 +
Morello JA, Lerner SA, Bohnhoff M:  Characteristics of atypical Neisseria gonorrhoeae from disseminated and localized infections . Infect Immun 13:1510-1516, 1976;.
6 +
Noble RC, Cooper RM, Miller BR:  Pharyngeal colonization by Neisseria gonorrhoeae and Neisseria meningitidis in black and white patients attending a venereal disease clinic . Br J Vener Dis 55:14-19, 1979;.
7 +
Willcox RR, Spencer RC, Ison C:  Which Neisseria? Br J Vener Dis 53:394-397, 1977;.
8 +
Young H, Harris AB, Robertson HH:  Individual susceptibility to neisserial infection? Br J Vener Dis 55:188-190, 1979;.
9 +
Goldmeier D, Darougar S:  Isolation of Chlamydia trachomatis from throat and rectum of homosexual men . Br J Vener Dis 53:184-185, 1977;.
10 +
Givan KF, Thomas DW, Johnston AG:  Isolation of Neisseria meningitidis from the urethra, cervix, and anal canal: Further observations . Br J Vener Dis 53:109-112, 1977;.
11 +
Judson FN, Ehret JM, Eickhoff TC:  Anogenital infection with Neisseria meningitidis in homosexual men . J Infect Dis 137:458-463, 1978;.
12 +
Merino HI, Richards JB:  An innovative program of venereal disease casefinding, treatment, and education for a population of gay men . Sex Transm Dis 4:50-52, 1977;.
13 +
Owen RL, Hill JL:  Rectal and pharyngeal gonorrhea in homosexual men . JAMA 220:1315-1318, 1972;.
14 +
McMillan A, Young H:  Gonorrhea in the homosexual man: Frequency of infection by culture site . Sex Transm Dis 5:146-150, 1978;.
15 +
Rein MF:  Epidemiology of gonococcal infections , in Roberts RB (ed): The Gonococcus . New York, John Wiley & Sons Inc, 1977;, pp 1-31.
16 +
Handsfield HH:  Clinical aspects of gonococcal infections , in Roberts RB (ed): The Gonococcus . New York, John Wiley & Sons Inc, 1977;, pp 57-79.
17 +
Knapp JS, Holmes KK:  Disseminated gonococcal infections caused by Neisseria gonorrhoeae with unique nutritional requirements . J Infect Dis 132:204-208, 1975;.
18 +
Crawford G, Knapp JS, Hale J, et al:  Asymptomatic gonorrhea in men: Caused by gonococci with unique nutritional requirements . Science 196:1352-1353, 1977;.
19 +
Knapp JS, Thornsberry C, Schoolnik GA, et al:  Phenotypic and epidemiologic correlates of auxotype in Neisseria gonorrhoeae . J Infect Dis 138:160-165, 1978;.
20 +
Volk J, Kraus SJ:  Asymptomatic meningococcal urethritis: Possible protective value against gonococcal infection by bacteriocin production . Br J Vener Dis 49:511-512, 1973;.

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