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ARTICLE |

Zinc Lowers High-Density Lipoprotein-Cholesterol Levels FREE

Philip L. Hooper, MD; Laurent Visconti; Philip J. Garry, PhD; Gregory E. Johnson, MD
[+] Author Affiliations

Reprint requests to Research Department, Veterans Administration Hospital, 2100 Ridgecrest SE, Albuquerque, NM 87108 (Dr Hooper).


JAMA. 1980;244(17):1960-1961. doi:10.1001/jama.1980.03310170058030
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Zinc administration in rats is associated with a rise in serum cholesterol level. This study examined the effect of zinc administration on serum lipoprotein values in man. Twelve healthy adult men ingested 440 mg of zinc sulfate per day for five weeks. High-density lipoprotein-cholesterol concentration decreased 25% below baseline values (40.5 to 30.1 mg/dL). Total cholesterol, triglyceride, and low-density lipoprotein-cholesterol levels did not change throughout the study. The sharp fall of the "antiatherogenic" lipoprotein, high-density lipoprotein, associated with zinc administration supports the concept that zinc ingestion may be atherogenic in man.

(JAMA 244:1960-1961, 1980)

REFERENCES

Klevay LM:  Hypercholesterolemia in rats produced by an increase in the ratio of zinc to copper ingested . Am J Clin Nutr 26:1060-1068, 1973;.
Klevay LM:  Coronary heart disease: The zinc/copper hypothesis . Am J Clin Nutr 28:764-774, 1975;.
Livin J, Zak B:  Automated determination of serum cholesterol . Clin Chem Acta 10:381-384, 1964;.
Kessler G, Lederer H:  Fluorimetric measurement of triglycerides , in Skeggs LT (ed): Automation in Analytical Chemistry: Technicon Symposia . New York, Mediad, 1965;, pp 341-344.
Lopes-Virella MD, Stone P, Ellis S, et al:  Cholesterol determinations in high density lipoprotein separated by three different methods . Clin Chem 23:882-884, 1977;.
Friedewalde WT, Levy RI, Fredrickson DS:  Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge . Clin Chem 18:499-502, 1972;.
Walravens PA, Hambidge KM:  Nutritional zinc deficiency in infants and children , in Brewer GT, Prasad AS (eds): Zinc Metabolism: Current Aspects in Health and Disease . New York, Alan R. Liss Inc, 1977;, pp 61-70.
Castelli WP, Doyle JT, Gordon T, et al:  HDL cholesterol and other lipids in coronary heart disease: The Cooperative Lipoprotein Phenotyping Study . Circulation 55:767-772, 1977;.
Osis D, Kramer L, Wiatrowski E, et al:  Dietary zinc intake in man . Am J Clin Nutr 25:582-588, 1972;.

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Klevay LM:  Hypercholesterolemia in rats produced by an increase in the ratio of zinc to copper ingested . Am J Clin Nutr 26:1060-1068, 1973;.
Klevay LM:  Coronary heart disease: The zinc/copper hypothesis . Am J Clin Nutr 28:764-774, 1975;.
Livin J, Zak B:  Automated determination of serum cholesterol . Clin Chem Acta 10:381-384, 1964;.
Kessler G, Lederer H:  Fluorimetric measurement of triglycerides , in Skeggs LT (ed): Automation in Analytical Chemistry: Technicon Symposia . New York, Mediad, 1965;, pp 341-344.
Lopes-Virella MD, Stone P, Ellis S, et al:  Cholesterol determinations in high density lipoprotein separated by three different methods . Clin Chem 23:882-884, 1977;.
Friedewalde WT, Levy RI, Fredrickson DS:  Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge . Clin Chem 18:499-502, 1972;.
Walravens PA, Hambidge KM:  Nutritional zinc deficiency in infants and children , in Brewer GT, Prasad AS (eds): Zinc Metabolism: Current Aspects in Health and Disease . New York, Alan R. Liss Inc, 1977;, pp 61-70.
Castelli WP, Doyle JT, Gordon T, et al:  HDL cholesterol and other lipids in coronary heart disease: The Cooperative Lipoprotein Phenotyping Study . Circulation 55:767-772, 1977;.
Osis D, Kramer L, Wiatrowski E, et al:  Dietary zinc intake in man . Am J Clin Nutr 25:582-588, 1972;.
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