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July 4, 1980, Vol 244, No. 1 >
ARTICLE | July 4, 1980

Evaluation of a New Antihypertensive Agent: Title and subTitle BreakMinoxidil FREE

Mary Ellen Kosman, PhD
[+] Author Affiliations

This communication was prepared with the assistance of a panel of independent consultants.

Reprint requests to Department of Drugs, American Medical Association, 535 N Dearborn St, Chicago, IL 60610 (Dr Kosman).


JAMA. 1980;244(1):73-75. doi:10.1001/jama.1980.03310010059037
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References

Minoxidil is a potent, long-acting, orally effective vasodilator that recently became available for general use in the United States. It is given with a diuretic and a β-blocking drug to treat severe hypertension that cannot be controlled by conventional therapy. Fluid retention and hypertrichosis are the most common adverse reactions.

(JAMA 244:73-75, 1980)

REFERENCES

1 +
Tarazi RC, Dustan HP, Bravo EL, et al:  Vasodilating drugs: Contrasting haemodynamic effects . Clin Sci Molec Med 51( (suppl 3) ):575-578, 1976;.
2 +
Gilmore E, Weil J, Chidsey C:  Treatment of essential hypertension with a new vasodilator in combination with beta-adrenergic blockade . N Engl J Med 282:521-527, 1970;.
3 +
Gottlieb TB, Katz FH, Chidsey CA:  Combined therapy with vasodilator drugs and betaadrenergic blockade in hypertension: A comparative study of minoxidil and hydralazine . Circulation 45:571-582, 1972;.
4 +
Limas CJ, Freis ED:  Minoxidil in severe hypertension with renal failure: Effect of its addition to conventional antihypertensive drugs . Am J Cardiol 31:355-361, 1973;.
5 +
Pettinger WA, Mitchell HC:  Minoxidil—an alternative to nephrectomy for refractory hypertension . N Engl J Med 289:167-171, 1973;.
6 +
Dormois JC, Young JL, Nies AS:  Minoxidil in severe hypertension: Value when conventional drugs have failed . Am Heart J 90:360-368, 1975;.
7 +
Mehta PK, Mamdani B, Shansky RM, et al:  Severe hypertension: Treatment with minoxidil . JAMA 233:249-252, 1975;.
8 +
Wilburn RL, Blaufuss A, Bennett CM:  Long-term treatment of severe hypertension with minoxidil, propranolol and furosemide . Circulation 52:706-713, 1975;.
9 +
Mutterperl RE, Diamond FB, Lowenthal DT:  Long-term effects of minoxidil in the treatment of malignant hypertension in chronic renal failure . J Clin Pharmacol 16:498-509, 1976;.
10 +
Zacest R, Frewin DB, Robinson MA, et al:  Clinical and haemodynamic effects of minoxidil in refractory hypertension . Drugs 11( (suppl 1) ):177-184, 1976;.
11 +
Nawar T, Nolin L, Plante GE, et al:  Long-term treatment of severe hypertension with minoxidil . Can Med Assoc J 117:1178-1182, 1977;.
12 +
Dargie HJ, Dollery CT, Daniel J:  Minoxidil in resistant hypertension . Lancet 2:515-518, 1977;.
13 +
Pennisi AJ, Takahashi M, Bernstein BH, et al:  Minoxidil therapy in children with severe hypertension . J Pediatr 90:813-819, 1977;.
14 +
Devine BL, Fife R, Trust PM:  Minoxidil for severe hypertension after failure of other hypotensive drugs . Br Med J 2:667-669, 1977;.
15 +
Mitchell HC, Pettinger WA:  Long-term treatment of refractory hypertensive patients with minoxidil . JAMA 239:2131-2138, 1978;.
16 +
Dustan HP, Tarazi RC, Bravo EL:  False tolerance to antihypertensive drugs , in Sambhi MP (ed): Systemic Effects of Antihypertensive Agents . New York, Stratton Intercontinental Medical Book Corp, 1976;, pp 51-68.
17 +
Tarazi RC, Ferrario CM, Dustan HP:  The heart in hypertension , in Genest J, Koiw E, Kuchel O (eds): Hypertension: Physiopathology and Treatment . New York, McGraw-Hill Book Co, 1977;, pp 738-754.
18 +
Atkins JM, Mitchell HC, Pettinger WA:  Increased pulmonary vascular resistance with systemic hypertension: Effect of minoxidil and other antihypertensive agents . Am J Cardiol 39:802-807, 1977;.
19 +
Klotman PE, Grim CE, Weinberger MH, et al:  The effects of minoxidil on pulmonary and systemic hemodynamics in hypertensive man . Circulation 55:394-400, 1977;.
20 +
Hall D, Charocopos F, Froer K-L, et al:  ECG changes during long-term minoxidil therapy for severe hypertension . Arch Intern Med 139:790-794, 1979;.

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1 +
Tarazi RC, Dustan HP, Bravo EL, et al:  Vasodilating drugs: Contrasting haemodynamic effects . Clin Sci Molec Med 51( (suppl 3) ):575-578, 1976;.
2 +
Gilmore E, Weil J, Chidsey C:  Treatment of essential hypertension with a new vasodilator in combination with beta-adrenergic blockade . N Engl J Med 282:521-527, 1970;.
3 +
Gottlieb TB, Katz FH, Chidsey CA:  Combined therapy with vasodilator drugs and betaadrenergic blockade in hypertension: A comparative study of minoxidil and hydralazine . Circulation 45:571-582, 1972;.
4 +
Limas CJ, Freis ED:  Minoxidil in severe hypertension with renal failure: Effect of its addition to conventional antihypertensive drugs . Am J Cardiol 31:355-361, 1973;.
5 +
Pettinger WA, Mitchell HC:  Minoxidil—an alternative to nephrectomy for refractory hypertension . N Engl J Med 289:167-171, 1973;.
6 +
Dormois JC, Young JL, Nies AS:  Minoxidil in severe hypertension: Value when conventional drugs have failed . Am Heart J 90:360-368, 1975;.
7 +
Mehta PK, Mamdani B, Shansky RM, et al:  Severe hypertension: Treatment with minoxidil . JAMA 233:249-252, 1975;.
8 +
Wilburn RL, Blaufuss A, Bennett CM:  Long-term treatment of severe hypertension with minoxidil, propranolol and furosemide . Circulation 52:706-713, 1975;.
9 +
Mutterperl RE, Diamond FB, Lowenthal DT:  Long-term effects of minoxidil in the treatment of malignant hypertension in chronic renal failure . J Clin Pharmacol 16:498-509, 1976;.
10 +
Zacest R, Frewin DB, Robinson MA, et al:  Clinical and haemodynamic effects of minoxidil in refractory hypertension . Drugs 11( (suppl 1) ):177-184, 1976;.
11 +
Nawar T, Nolin L, Plante GE, et al:  Long-term treatment of severe hypertension with minoxidil . Can Med Assoc J 117:1178-1182, 1977;.
12 +
Dargie HJ, Dollery CT, Daniel J:  Minoxidil in resistant hypertension . Lancet 2:515-518, 1977;.
13 +
Pennisi AJ, Takahashi M, Bernstein BH, et al:  Minoxidil therapy in children with severe hypertension . J Pediatr 90:813-819, 1977;.
14 +
Devine BL, Fife R, Trust PM:  Minoxidil for severe hypertension after failure of other hypotensive drugs . Br Med J 2:667-669, 1977;.
15 +
Mitchell HC, Pettinger WA:  Long-term treatment of refractory hypertensive patients with minoxidil . JAMA 239:2131-2138, 1978;.
16 +
Dustan HP, Tarazi RC, Bravo EL:  False tolerance to antihypertensive drugs , in Sambhi MP (ed): Systemic Effects of Antihypertensive Agents . New York, Stratton Intercontinental Medical Book Corp, 1976;, pp 51-68.
17 +
Tarazi RC, Ferrario CM, Dustan HP:  The heart in hypertension , in Genest J, Koiw E, Kuchel O (eds): Hypertension: Physiopathology and Treatment . New York, McGraw-Hill Book Co, 1977;, pp 738-754.
18 +
Atkins JM, Mitchell HC, Pettinger WA:  Increased pulmonary vascular resistance with systemic hypertension: Effect of minoxidil and other antihypertensive agents . Am J Cardiol 39:802-807, 1977;.
19 +
Klotman PE, Grim CE, Weinberger MH, et al:  The effects of minoxidil on pulmonary and systemic hemodynamics in hypertensive man . Circulation 55:394-400, 1977;.
20 +
Hall D, Charocopos F, Froer K-L, et al:  ECG changes during long-term minoxidil therapy for severe hypertension . Arch Intern Med 139:790-794, 1979;.

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