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ARTICLE |

Marijuana for Drug-Induced Nausea and Vomiting FREE

Donald L. Sweet, MD
JAMA. 1980;243(12):1265-1265. doi:10.1001/jama.1980.03300380045025
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In 1975 investigators at the Sidney Farber Cancer Institute in Boston became intrigued by reports from some young patients who said that when they were "high" from smoking "pot," they experienced less or none of the severe nausea and vomiting that usually accompanied their cancer chemotherapy treatments. The investigators subsequently developed a protocol to test the antiemetic effects of Δ9-tetrahydrocannabinol (THC), the principal mood-altering agent in marijuana. Of the patients receiving THC, 25% did not vomit at all, and 45% experienced a substantial reduction of their vomiting.1 In a control group that received a placebo, 73% reported no reduction in nausea or vomiting. Those patients who experienced euphoria were the most likely to also experience a reduction in nausea and vomiting. Toxic effects were tolerable, but a few patients suffered paranoid ideation, feelings of terror, panic, and visual hallucinations. Nevertheless, the Sidney Farber study provoked renewed interest

REFERENCES

Sallan SE, Zinberg NE, Frei E:  Antiemetic effect of delta-9-tetrahydrocannabinol in patients receiving cancer chemotherapy . N Engl J Med 293:795-797, 1975;.
Henney J:  Antiemetic research working group: Minutes of March 22, 1979, meeting , in The Interagency Committee on New Therapies for Pain and Discomfort: Report to the White House . US Dept of Health, Education, and Welfare, (May) 1979;.
Herman TS, Einhorn LH, Jones SE:  Superiority of nabilone over prochlorperazine as an antiemetic in patients receiving cancer chemotherapy . N Engl J Med 300:1295-1297, 1979;.
Treffert DA:  Marihuana use in schizophrenia, a clear hazard . Am J Psychiatry 135:1213-1215, 1978;.
Cohen S:  Marihuana: A new ball game? Drug Abuse and Alcoholism Newsletter Vol 8, 1979;.
Frytak S, Moertel CG, O'Fallon JR:  A comparison of delta-9-tetrahydracannabinol, prochlorperazine and placebo as antiemetics for cancer chemotherapy . Am Soc Clin Oncology , No. (C-414) , p 391, 1979;.

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Sallan SE, Zinberg NE, Frei E:  Antiemetic effect of delta-9-tetrahydrocannabinol in patients receiving cancer chemotherapy . N Engl J Med 293:795-797, 1975;.
Henney J:  Antiemetic research working group: Minutes of March 22, 1979, meeting , in The Interagency Committee on New Therapies for Pain and Discomfort: Report to the White House . US Dept of Health, Education, and Welfare, (May) 1979;.
Herman TS, Einhorn LH, Jones SE:  Superiority of nabilone over prochlorperazine as an antiemetic in patients receiving cancer chemotherapy . N Engl J Med 300:1295-1297, 1979;.
Treffert DA:  Marihuana use in schizophrenia, a clear hazard . Am J Psychiatry 135:1213-1215, 1978;.
Cohen S:  Marihuana: A new ball game? Drug Abuse and Alcoholism Newsletter Vol 8, 1979;.
Frytak S, Moertel CG, O'Fallon JR:  A comparison of delta-9-tetrahydracannabinol, prochlorperazine and placebo as antiemetics for cancer chemotherapy . Am Soc Clin Oncology , No. (C-414) , p 391, 1979;.
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