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February 15, 1980, Vol 243, No. 7 >
ARTICLE | February 15, 1980

Urine Calcitonin Levels in Patients With Bronchogenic Carcinoma FREE

Kenneth L. Becker, MD, PhD; Donald R. Nash, PhD; Omega L. Silva, MD; Richard H. Snider, PhD; Charles F. Moore
[+] Author Affiliations

Reprint requests to Metabolic Research, Veterans Administration Medical Center, 50 Irving St NW, Washington, DC 20422 (Dr Becker).


JAMA. 1980;243(7):670-672. doi:10.1001/jama.1980.03300330028025
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References

We demonstrated previously that high serum calcitonin values in bronchogenic carcinoma are useful clinically as a parameter of progress of the disease and response to therapy. After developing a procedure for the measurement of calcitonin in urine, we studied serum and urine levels in 41 patients with lung cancer, using both a carboxyl terminus and a midportion recognizing antiserum. In general, midportion antiserum was more useful. Urine calcitonin measurements alone were superior to serum in terms of numbers of patients having increased values with one or both antisera (76% vs 46%). When both antisera were used to assay both serum and urine, 90% of patients had abnormal values. Once a tissue diagnosis has been established, the radioimmunoassay of urinary calcitonin offers a new dimension to the utility of this hormone as a marker for bronchogenic carcinoma.

(JAMA 243:670-672, 1980)

REFERENCES

1 +
Silva OL, Becker KL, Primack A, et al:  Increased serum calcitonin in bronchogenic cancer . Chest 69:495-499, 1976;.
2 +
Becker KL, Snider RH, Silva OL, et al:  Calcitonin heterogeneity in lung cancer and medullary thyroid cancer . Acta Endocrinol 89:89-99, 1978;.
3 +
Silva OL, Becker KL, Primack A, et al:  Ectopic secretion of calcitonin in oat cell carcinoma . N Engl J Med 290:1122-1124, 1974;.
4 +
Silva OL, Becker KL, Primack A, et al:  Hypercalcitonemia in bronchogenic cancer: Evidence for thyroid origin of the hormone . JAMA 234:183-185, 1975;.
5 +
Silva OL, Snider RH, Moore CF, et al:  Urine calcitonin as a test for medullary thyroid cancer . Ann Surg 189:269-274, 1979;.
6 +
Silva OL, Snider RH, Becker KL:  Radioimmunoassay of human calcitonin in human plasma . Clin Chem 20:337-339, 1974;.
7 +
Snider RH, Silva OL, Moore CF, et al:  Immunochemical heterogeneity of calcitonin in man: Effect on radioimmunoassay . Clin Chim Acta 76:1-14, 1977;.
8 +
Snider RH, Moore CF, Silva OL, et al:  Radioimmunoassay of calcitonin in the urine of normal man . Anal Chem 50:449-454, 1978;.
9 +
Silva OL, Broder LE, Doppman JL, et al:  Calcitonin as a marker for bronchogenic cancer: A prospective study . Cancer 44:334-338, 1979;.
10 +
Silva OL, Becker KL:  Calcitonin as a marker for cancer , in Rudden RW (ed): Biological Markers of Neoplasia: Basic and Applied Aspects . Amsterdam, Elsevier North Holland Inc, 1978;, pp 295-310.
11 +
Silva OL, Becker KL, Shalhoub RJ, et al:  Calcitonin levels in chronic renal disease . Nephron 19:12-18, 1977;.
12 +
Heynen G, Franchimont P:  Human calcitonin radioimmunoassay in normal and pathological conditions . Eur J Clin Invest 4:213-222, 1974;.
13 +
Sizemore G, Go VL, Kaplan EL, et al:  Relations of calcitonin and gastrin in the Zollinger-Ellison syndrome and medullary carcinoma of the thyroid . N Engl J Med 288:641-644, 1973;.
14 +
Tashjian AH Jr, Voelkel EF, Wolfe HJ, et al:  Calcitonin and prostaglandins: Significance, relevance, and uncertainties , in Talmage RV, Owen M, Parsons JA (eds): Calcium Regulating Hormones . Amsterdam, Excerpta Medica, 1975;, pp 135-148.
15 +
Samaan NA, Anderson GD, Adam-Mayne ME:  Immunoreactive calcitonin in the mother, neonate, child, and adult . Am J Obstet Gynecol 121:622-625, 1975;.
16 +
Becker KL, Nash DR, Silva OL, et al:  Increased calcitonin in lung disease . Clin Res , to be published.

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1 +
Silva OL, Becker KL, Primack A, et al:  Increased serum calcitonin in bronchogenic cancer . Chest 69:495-499, 1976;.
2 +
Becker KL, Snider RH, Silva OL, et al:  Calcitonin heterogeneity in lung cancer and medullary thyroid cancer . Acta Endocrinol 89:89-99, 1978;.
3 +
Silva OL, Becker KL, Primack A, et al:  Ectopic secretion of calcitonin in oat cell carcinoma . N Engl J Med 290:1122-1124, 1974;.
4 +
Silva OL, Becker KL, Primack A, et al:  Hypercalcitonemia in bronchogenic cancer: Evidence for thyroid origin of the hormone . JAMA 234:183-185, 1975;.
5 +
Silva OL, Snider RH, Moore CF, et al:  Urine calcitonin as a test for medullary thyroid cancer . Ann Surg 189:269-274, 1979;.
6 +
Silva OL, Snider RH, Becker KL:  Radioimmunoassay of human calcitonin in human plasma . Clin Chem 20:337-339, 1974;.
7 +
Snider RH, Silva OL, Moore CF, et al:  Immunochemical heterogeneity of calcitonin in man: Effect on radioimmunoassay . Clin Chim Acta 76:1-14, 1977;.
8 +
Snider RH, Moore CF, Silva OL, et al:  Radioimmunoassay of calcitonin in the urine of normal man . Anal Chem 50:449-454, 1978;.
9 +
Silva OL, Broder LE, Doppman JL, et al:  Calcitonin as a marker for bronchogenic cancer: A prospective study . Cancer 44:334-338, 1979;.
10 +
Silva OL, Becker KL:  Calcitonin as a marker for cancer , in Rudden RW (ed): Biological Markers of Neoplasia: Basic and Applied Aspects . Amsterdam, Elsevier North Holland Inc, 1978;, pp 295-310.
11 +
Silva OL, Becker KL, Shalhoub RJ, et al:  Calcitonin levels in chronic renal disease . Nephron 19:12-18, 1977;.
12 +
Heynen G, Franchimont P:  Human calcitonin radioimmunoassay in normal and pathological conditions . Eur J Clin Invest 4:213-222, 1974;.
13 +
Sizemore G, Go VL, Kaplan EL, et al:  Relations of calcitonin and gastrin in the Zollinger-Ellison syndrome and medullary carcinoma of the thyroid . N Engl J Med 288:641-644, 1973;.
14 +
Tashjian AH Jr, Voelkel EF, Wolfe HJ, et al:  Calcitonin and prostaglandins: Significance, relevance, and uncertainties , in Talmage RV, Owen M, Parsons JA (eds): Calcium Regulating Hormones . Amsterdam, Excerpta Medica, 1975;, pp 135-148.
15 +
Samaan NA, Anderson GD, Adam-Mayne ME:  Immunoreactive calcitonin in the mother, neonate, child, and adult . Am J Obstet Gynecol 121:622-625, 1975;.
16 +
Becker KL, Nash DR, Silva OL, et al:  Increased calcitonin in lung disease . Clin Res , to be published.

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