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ARTICLE |

Mitochondrial Creatine Kinase: Title and subTitle BreakA Poor Prognostic Sign FREE

C. Jack Bark, MD
[+] Author Affiliations

Reprint requests to Alvarado Community Hospital, 6655 Alvarado Rd, San Diego, CA 92120 (Dr Bark).


JAMA. 1980;243(20):2058-2060. doi:10.1001/jama.1980.03300460040024
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A serum creatine kinase (CK) isoenzyme band cathodic to MM, thought to represent mitochondrial CK, was found in eight patients in shock, six of whom died within 12 days. Severe tissue damage appears to be required to release this isoenzyme to detectable levels in the serum.

(JAMA 243:2058-2060, 1980)

REFERENCES

Farrell EC Jr, Baba N, Brierley GP, et al:  On the creatine phosphokinase of heart muscle mitochondria . Lab Invest 27:209-213, 1972;.
Jacobs H, Heldt HW, Klingenberg M:  High activity of creatine kinase in mitochondria from muscle and brain and evidence for a separate mitochondrial isoenzyme of creatine kinase . Biochem Biophys Res Commun 16:516-521, 1964;.
Sobol BE, Shell WE, Klein MS:  An isoenzyme of creatine phosphokinase associated with rabbit heart mitochondria . J Mol Cell Cardiol 4:367-380, 1972;.
Somer H, Uotila A, Konttinen A, et al:  Creatine kinase activity and its isoenzyme pattern in heart mitochondria . Clin Chim Acta 53:369-372, 1974;.
Ljungdahl L, Gerhardt W:  Creatine kinase isoenzyme variants in human serum . Clin Chem 24:832-834, 1978;.
Sax IM, Moore JJ, Giegel JL, et al:  Atypical increase in serum creatine kinase activity in hospital patients . Clin Chem 22:87-91, 1976;.
Rock RC, Dreskin R, Kickler T, et al:  Creatine kinase isoenzymes in serum of patients with Reye's syndrome . Clin Chim Acta 62:159-162, 1975;.
Urdal P, Landaas S:  Macro creatine kinase BB in serum, and some data on its prevalence . Clin Chem 25:461-465, 1979;.
James GP, Harrison RL:  Creatine kinase isoenzymes of mitochondrial origin in human serum . Clin Chem 25:943-947, 1979;.
Sanders JL, Joung JI, Rochman H:  The further heterogeneity of creatine kinase, presence of isoenzymes of cathodic mobility in rat tissues . Biochem Biophys Acta 438:407-411, 1976;.
Baillie EE:  CK isoenzymes: I. Clinical aspects . Lab Med 10:267-276, 1979;.

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Farrell EC Jr, Baba N, Brierley GP, et al:  On the creatine phosphokinase of heart muscle mitochondria . Lab Invest 27:209-213, 1972;.
Jacobs H, Heldt HW, Klingenberg M:  High activity of creatine kinase in mitochondria from muscle and brain and evidence for a separate mitochondrial isoenzyme of creatine kinase . Biochem Biophys Res Commun 16:516-521, 1964;.
Sobol BE, Shell WE, Klein MS:  An isoenzyme of creatine phosphokinase associated with rabbit heart mitochondria . J Mol Cell Cardiol 4:367-380, 1972;.
Somer H, Uotila A, Konttinen A, et al:  Creatine kinase activity and its isoenzyme pattern in heart mitochondria . Clin Chim Acta 53:369-372, 1974;.
Ljungdahl L, Gerhardt W:  Creatine kinase isoenzyme variants in human serum . Clin Chem 24:832-834, 1978;.
Sax IM, Moore JJ, Giegel JL, et al:  Atypical increase in serum creatine kinase activity in hospital patients . Clin Chem 22:87-91, 1976;.
Rock RC, Dreskin R, Kickler T, et al:  Creatine kinase isoenzymes in serum of patients with Reye's syndrome . Clin Chim Acta 62:159-162, 1975;.
Urdal P, Landaas S:  Macro creatine kinase BB in serum, and some data on its prevalence . Clin Chem 25:461-465, 1979;.
James GP, Harrison RL:  Creatine kinase isoenzymes of mitochondrial origin in human serum . Clin Chem 25:943-947, 1979;.
Sanders JL, Joung JI, Rochman H:  The further heterogeneity of creatine kinase, presence of isoenzymes of cathodic mobility in rat tissues . Biochem Biophys Acta 438:407-411, 1976;.
Baillie EE:  CK isoenzymes: I. Clinical aspects . Lab Med 10:267-276, 1979;.
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