Postpartum Thyrotoxicosis in a Patient With Graves' Disease: Title and subTitle BreakAssociation With Low Radioactive Iodine Uptake FREE

Robert H. Eckel, MD; William L. Green, MD

[+] Author Affiliations

Reprint requests to Harborview Medical Center, 325 Ninth Ave, Seattle, WA 98104 (Dr Green).

JAMA. 1980;243(14):1454-1456. doi:10.1001/jama.1980.03300400038027

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ABSTRACT

ABSTRACT | REFERENCES

A patient with previously diagnosed Graves' hyperthyroidism had a transient episode of thyrotoxicosis three months postpartum. This was associated with a diffusely enlarged thyroid gland, a rise in antithyroid microsomal antibody titer, a 24-hour radioactive iodine uptake (RAIU) of 1%, and an aspiration biopsy specimen suggestive of chronic lymphocytic thyroiditis. An alternative cause for the depressed RAIU was not discovered. This case would suggest that patients with previously diagnosed Graves' disease can have thyrotoxicosis without an enhanced RAIU and that the postpartum thyrotoxic syndrome may involve an immunologic injury causing a release of preformed thyroid hormone.

(JAMA 243:1454-1456, 1980)

REFERENCES

ABSTRACT | REFERENCES

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Volpe R, Row VV, Webster BR, et al: Studies of iodine metabolism in Hashimoto's thyroiditis . J Clin Endocrinol Metab 25:593-601, 1965;.

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Savoie JC, Massin JP, Thomopoulos P, et al: Iodine-induced thyrotoxicosis in apparently normal thyroid glands . J Clin Endocrinol Metab 41:685-691, 1975;.

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