0
August 17, 1979, Vol 242, No. 7 >
ARTICLE | August 17, 1979

Epidemiology of Hepatocellular Adenoma: Title and subTitle BreakThe Role of Oral Contraceptive Use FREE

Judith Bourne Rooks, CNM, MS, MPH; Howard W. Ory, MD, MSc; Kamal G. Ishak, MD, PhD; Lilo T. Strauss, MS; Joel R. Greenspan, MD; Annlia Paganini Hill, PhD; Carl W. Tyler, Jr, MD
[+] Author Affiliations

Reprint requests to Epidemiologic Studies Branch, Family Planning Evaluation Division, Bureau of Epidemiology, Bldg 1, Room 4409, Center for Disease Control, 1600 Clifton Rd, Atlanta, GA 30333 (Dr Ory).


JAMA. 1979;242(7):644-648. doi:10.1001/jama.1979.03300070040020
Text Size: A A A
Published online
Article
References

A case-control study of hepatocellular adenoma (HCA), a serious though nonmalignant liver tumor, was conducted by the Center for Disease Control and the Armed Forces Institute of Pathology (AFIP). Interviews with 79 women with HCA and with 220 age- and neighborhood-matched controls were completed. Limited information was obtained on nine additional patients who had died. Women with HCA and hemorrhage have a greater risk of morbidity and death than those with other symptoms. Increasing duration of OC use increases the risk of HCA. Use of OCs with high hormonal potency and age over 30 years may further increase a woman's risk of HCA. Long-term users of OCs have an estimated annual incidence of HCA of 3 to 4 per 100,000.

(JAMA 242:644-648, 1979)

REFERENCES

1 +
Baum JK, Holtz F, Bookstein JJ, et al:  Possible association between benign hepatomas and oral contraceptives . Lancet 2:926-929, 1976;.
2 +
Wavri WN:  Primary neoplasms of the liver . Arch Pathol 37:367-376, 1944;.
3 +
Lansin PB, McQuitty JT, Bradburn DM:  Benign liver tumors: What is their relationship to oral contraceptives? Am Surg 42:744-760, 1976;.
4 +
Edmondson HA, Henderson B, Benton B:  Liver-cell adenomas association with use of oral contraceptives . N Engl J Med 294:470-472, 1976;.
5 +
Ishak KG, Rabin L:  Benign tumors of the liver . Med Clin North Am 59:995-1002, 1975;.
6 +
Heinen G:  Discriminating use of combination and sequential preparations in the hormonal inhibition of ovulation . Contraception 4:393-400, 1971;.
7 +
Greenblatt RB:  Progestational agents in clinical practice . Med Sci 18:37, 1967;.
8 +
Hill AP, Pike MC, Smith PG, et al:  Stratified analysis of case-control studies with the factor under study taking multiple values . J Chronic Dis 31:547-555, 1978;.
9 +
Hellman LM, Pritchard JA: Williams Obstetrics , ed 14. New York, Appleton-Century-Crofts, 1971;, pp 104-105.
10 +
Westoff CF:  Trends in contraceptive practice: 1965-1973 . Fam Plann Perspect 8:54-57, 1976;.
11 +
National Center for Health Statistics:  Contraceptive utilization among currently married women 15-44 years of age: U.S., 1973 . Monthly Vital Stat Rep 25( (suppl) ):1-8, 1976;.
12 +
Stolley PD, Tonascia JA, Sartwell PE, et al:  Agreement rates between oral contraceptive users and prescribers in relation to drug use histories . Am J Epidemiol 107:226-235, 1978;.
13 +
Glass R, Johnson B, Vessey M:  Accuracy of recall of histories of oral contraceptive use . Br J Prev Soc Med 28:273-275, 1974;.
14 +
Schardein JL, Kaump DH, Woolsey ET, et al:  Long term toxicologic and tumorigenises studies on an oral contraceptive agent in albino rats . Tox Appl Pharmacol 16:10-23, 1970;.
15 +
Committee on Safety of Medicines: Carcinogenicity Tests of Oral Contraceptives. London, Her Majesty's Stationery Office, 1972.
16 +
Edmondson HA, Reynolds TB, Henderson B, et al:  Regression of liver cell adenomas association with oral contraceptives . Ann Intern Med 86:180-182, 1977;.
17 +
Cornish PG:  Liver cell adenoma . JAMA 235:249, 1976;.
18 +
Anderson PH, Packer JT:  Hepatic adenoma: Observations after estrogen withdrawal . Arch Surg 111:898-900, 1976;.
19 +
Ramseur WL, Cooper MR:  Asymptomatic liver cell adenomas . JAMA 239:1647-1648, 1978;.
20 +
Kay S:  Nine year follow-up of a case of benign liver cell adenoma related to oral contraceptives . Cancer 40:1759-1760, 1977;.
21 +
Dalen E, Westerholm B:  Occurrence of hepatic impairment in women jaundiced by oral contraceptives and in their mothers and sisters . Acta Med Scand 1975:459-463, 1974;.
22 +
Murphy GP:  American College of Surgeons Commission on cancer survey supports suggested association between oral contraceptive usage and liver tumors . Am Coll Surg Bull 62:28, 1977;.
23 +
Bureau of the Census:  Estimates of the population of the United States, by age, sex, and race: 1970 to 1975 . Population Rep , series P-25, No. (614) , 1970;-1975, p 13.
24 +
Jick H, Herman R:  Oral contraceptive-induced benign liver tumors—the magnitude of the problem . JAMA 240:828-829, 1978;.

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

1 +
Baum JK, Holtz F, Bookstein JJ, et al:  Possible association between benign hepatomas and oral contraceptives . Lancet 2:926-929, 1976;.
2 +
Wavri WN:  Primary neoplasms of the liver . Arch Pathol 37:367-376, 1944;.
3 +
Lansin PB, McQuitty JT, Bradburn DM:  Benign liver tumors: What is their relationship to oral contraceptives? Am Surg 42:744-760, 1976;.
4 +
Edmondson HA, Henderson B, Benton B:  Liver-cell adenomas association with use of oral contraceptives . N Engl J Med 294:470-472, 1976;.
5 +
Ishak KG, Rabin L:  Benign tumors of the liver . Med Clin North Am 59:995-1002, 1975;.
6 +
Heinen G:  Discriminating use of combination and sequential preparations in the hormonal inhibition of ovulation . Contraception 4:393-400, 1971;.
7 +
Greenblatt RB:  Progestational agents in clinical practice . Med Sci 18:37, 1967;.
8 +
Hill AP, Pike MC, Smith PG, et al:  Stratified analysis of case-control studies with the factor under study taking multiple values . J Chronic Dis 31:547-555, 1978;.
9 +
Hellman LM, Pritchard JA: Williams Obstetrics , ed 14. New York, Appleton-Century-Crofts, 1971;, pp 104-105.
10 +
Westoff CF:  Trends in contraceptive practice: 1965-1973 . Fam Plann Perspect 8:54-57, 1976;.
11 +
National Center for Health Statistics:  Contraceptive utilization among currently married women 15-44 years of age: U.S., 1973 . Monthly Vital Stat Rep 25( (suppl) ):1-8, 1976;.
12 +
Stolley PD, Tonascia JA, Sartwell PE, et al:  Agreement rates between oral contraceptive users and prescribers in relation to drug use histories . Am J Epidemiol 107:226-235, 1978;.
13 +
Glass R, Johnson B, Vessey M:  Accuracy of recall of histories of oral contraceptive use . Br J Prev Soc Med 28:273-275, 1974;.
14 +
Schardein JL, Kaump DH, Woolsey ET, et al:  Long term toxicologic and tumorigenises studies on an oral contraceptive agent in albino rats . Tox Appl Pharmacol 16:10-23, 1970;.
15 +
Committee on Safety of Medicines: Carcinogenicity Tests of Oral Contraceptives. London, Her Majesty's Stationery Office, 1972.
16 +
Edmondson HA, Reynolds TB, Henderson B, et al:  Regression of liver cell adenomas association with oral contraceptives . Ann Intern Med 86:180-182, 1977;.
17 +
Cornish PG:  Liver cell adenoma . JAMA 235:249, 1976;.
18 +
Anderson PH, Packer JT:  Hepatic adenoma: Observations after estrogen withdrawal . Arch Surg 111:898-900, 1976;.
19 +
Ramseur WL, Cooper MR:  Asymptomatic liver cell adenomas . JAMA 239:1647-1648, 1978;.
20 +
Kay S:  Nine year follow-up of a case of benign liver cell adenoma related to oral contraceptives . Cancer 40:1759-1760, 1977;.
21 +
Dalen E, Westerholm B:  Occurrence of hepatic impairment in women jaundiced by oral contraceptives and in their mothers and sisters . Acta Med Scand 1975:459-463, 1974;.
22 +
Murphy GP:  American College of Surgeons Commission on cancer survey supports suggested association between oral contraceptive usage and liver tumors . Am Coll Surg Bull 62:28, 1977;.
23 +
Bureau of the Census:  Estimates of the population of the United States, by age, sex, and race: 1970 to 1975 . Population Rep , series P-25, No. (614) , 1970;-1975, p 13.
24 +
Jick H, Herman R:  Oral contraceptive-induced benign liver tumors—the magnitude of the problem . JAMA 240:828-829, 1978;.

Letters

Submit a Letter
CME Course for:


You need to register in order to view this quiz.


To understand the clinical management of acute heart failure syndromes.
Accreditation Information The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
To view and print your certificate and access a summary of your CME courses go to My CME.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s “Cited By” API will populate this tab (http://www.crossref.org/citedby.html).
Compression-Only CPR: Pushing the Science Forward
Cone
AAM 2010;304:1493-1495.
All you need to read in the other general journals
BMJ 2010;341:c5893-c1494.
Submit a Response

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

© 2012 American Medical Association. All Rights Reserved.
Powered bySilverchair Information Systems