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ARTICLE |

Zinc Metabolism in Sickle Cell Anemia FREE

Harvey B. Niell, MD; Byron E. Leach, PhD; Alfred P. Kraus, MD
[+] Author Affiliations

Deceased.

Reprint requests to Division of Hematology, University of Tennessee Center for the Health Sciences, 800 Madison Av, Memphis, TN 38163 (Dr Niell).


JAMA. 1979;242(24):2686-2687. doi:10.1001/jama.1979.03300240026019
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Zinc metabolism was studied in 34 patients with sickle cell anemia in a steady state and in six patients during sickle cell crisis. The patients in steady state were found to have significantly lower plasma levels and higher urinary levels of zinc than the 50 healthy adults in the control group. During sickle cell crisis the plasma zinc levels dropped to a mean value of 0.54 μg/mL from a steady state value of 0.79 μg/mL. These results support the concept that zinc deficiency occurs in sickle cell anemia and that further drops occur in the serum zinc levels during sickle cell crisis.

(JAMA 242:2686-2687, 1979)

REFERENCES

Prasad AS, Schoomaker EB, Ortega J, et al:  Zinc deficiency in sickle cell disease . Clin Chem 21:582-587, 1975;.
Prasad AS, Ortega J, Brewer GJ, et al:  Trace elements in sickle cell disease . JAMA 235:2396-2398, 1976;.
Prasad AS, Oberleas D, Halstead JA:  Determination of zinc in biological fluids by atomic absorption spectrophotometry in normal and cirrhotic subjects . J Lab Clin Med 66:508-516, 1965;.
Kapu MM, Fleming AF, Ezem BU:  Plasmazinc in sickle cell anemia . Lancet 1:920, 1976;.
Butler LC, Taylor ML, McCurdy PR, et al:  Zinc status in adult sickle cell anemia patients , abstracted. Fed Am Soc Exp Biol 36:1139, 1977;.
Tosteson DC, Shea E, Darling RC:  Potassium and sodium of red blood cells in sickle cell anemia . J Clin Invest 31:406-411, 1952;.
Eaton JW, Skelton TD, Swofford HS, et al:  Elevated erythrocyte calcium in sickle cell disease . Nature 246:105-106, 1973;.
Falchuk KH:  Effect of acute disease and ACTH on serum zinc proteins . N Engl J Med 296:1129-1134, 1977;.

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Prasad AS, Schoomaker EB, Ortega J, et al:  Zinc deficiency in sickle cell disease . Clin Chem 21:582-587, 1975;.
Prasad AS, Ortega J, Brewer GJ, et al:  Trace elements in sickle cell disease . JAMA 235:2396-2398, 1976;.
Prasad AS, Oberleas D, Halstead JA:  Determination of zinc in biological fluids by atomic absorption spectrophotometry in normal and cirrhotic subjects . J Lab Clin Med 66:508-516, 1965;.
Kapu MM, Fleming AF, Ezem BU:  Plasmazinc in sickle cell anemia . Lancet 1:920, 1976;.
Butler LC, Taylor ML, McCurdy PR, et al:  Zinc status in adult sickle cell anemia patients , abstracted. Fed Am Soc Exp Biol 36:1139, 1977;.
Tosteson DC, Shea E, Darling RC:  Potassium and sodium of red blood cells in sickle cell anemia . J Clin Invest 31:406-411, 1952;.
Eaton JW, Skelton TD, Swofford HS, et al:  Elevated erythrocyte calcium in sickle cell disease . Nature 246:105-106, 1973;.
Falchuk KH:  Effect of acute disease and ACTH on serum zinc proteins . N Engl J Med 296:1129-1134, 1977;.
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