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October 26, 1979, Vol 242, No. 17 >
ARTICLE | October 26, 1979

Cytotoxic-lnduced Ovarian Failure in Hodgkin's Disease: Title and subTitle BreakII. Effects on Sexual Function FREE

Ramona M. Chapman, MD; Simon B. Sutcliffe, MD, MRCP; James S. Malpas, DPhil, FRCP
[+] Author Affiliations

This material was presented in part before a meeting of the Royal Society of Medicine, London, Dec 20, 1978.

Reprint requests to Hematology-Oncology Service, Walter Reed Army Medical Center, Washington, DC 20012 (Dr Chapman).


JAMA. 1979;242(17):1882-1884. doi:10.1001/jama.1979.03300170028021
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References

Chemotherapy for Hodgkin's disease produces ovarian failure in young women. The consequences of this are emotional distress, sexual dysfunction, and the disruption of families and friendships. These previously unappreciated side effects of cytotoxic therapy had developed in 25 of 41 patients, among whom we conducted a retrospective study.

(JAMA 242:1882-1884, 1979)

REFERENCES

1 +
Sutcliffe SB, Wrigley PFM, Peto J, et al:  MVPP chemotherapy regimen for advanced Hodgkin's disease . Br Med J 1:679-683, 1978;.
2 +
Van Thiel DH, Ross GT, Lipsett MB:  Pregnancies after chemotherapy of trophoblastic neoplasms . Science 169:1326-1327, 1970;.
3 +
Li FP, Jaffe N:  Progeny of childhood cancer survivors . Lancet 2:707-709, 1974;.
4 +
Sarkar SD, Beierwaltes WH, Gill SP, et al:  Subsequent fertility and birth histories of children and adolescents treated with I131 for thyroid cancer . J Nucl Med 17:460-464, 1976;.
5 +
Cohen MM, Gerbie AB, Nadler HL:  Chromosomal investigation in pregnancies following chemotherapy for choriocarcinoma . Lancet 2:219, 1971;.
6 +
Whelton JA, McSweeney DJ:  Successful pregnancy after radiation therapy for carcinoma of the cervix . Am J Obstet Gynecol 88:443-446, 1964;.
7 +
Awa AA, Bloom AD, Yoshida MC, et al:  Cytogenetic study of the offspring of atom bomb survivors . Nature 218:367-368, 1968;.
8 +
Awa AA, Honda T, Sofuni T, et al:  Chromosome-aberration frequency in cultured blood cells in relation to radiation dose of A-bomb survivors . Lancet 2:903-905, 1971;.
9 +
Holmes GE, Holmes FF:  Pregnancy outcome of patients treated for Hodgkin's disease . Cancer 41:1317-1322, 1978;.
10 +
Chapman RM, Sutcliffe SB, Rees LR, et al:  Cyclical combination chemotherapy and gonadal function: Retrospective male study . Lancet 1:285-289, 1979;.
11 +
England and Wales . Population Series FM2 No. 2 (1901-1975), London, 1975;, p 3.
12 +
Kumar R, McEvoy J, Biggart JD, et al:  Cyclophosphamide and reproductive function . Lancet 1:1212-1214, 1972;.
13 +
Udall PR, Kerr DNS, Tacchi D:  Sterility and cyclophosphamide . Lancet 1:693-694, 1972;.
14 +
Floch OL, Donaldson Sarah S, Kaplan HS:  Pregnancy following oophoropexy and total nodal irradiation in women with Hodgkin's disease . Cancer 38:2263-2268, 1976;.
15 +
Warne GL, Fairley KF, Hobbs JB, et al:  Cyclophosphamide-induced ovarian failure . N Engl J Med 289:1159-1162, 1973;.
16 +
Sobrino LG, Levine RA, DeConti RC:  Amenorrhea in patients with Hodgkin's disease treated with antineoplastic agents . Am J Obstet Gynecol 109:135-139, 1971;.
17 +
Himelstein-Braw R, Peters H, Faber H:  Influence of irradiation and chemotherapy on the ovaries of children with abdominal tumors . Br J Cancer 36:269-274, 1977;.
18 +
Rose DP, Davis TE:  Ovarian function in patients receiving adjuvant chemotherapy for breast cancer . Lancet 1:1174-1176, 1977;.
19 +
Samaan NA, DeAsis DN Jr, Buzdar AV, et al:  Pituitary-ovarian function in breast cancer patients on adjuvant chemoimmunotherapy . Cancer 41:2084-2087, 1978;.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

1 +
Sutcliffe SB, Wrigley PFM, Peto J, et al:  MVPP chemotherapy regimen for advanced Hodgkin's disease . Br Med J 1:679-683, 1978;.
2 +
Van Thiel DH, Ross GT, Lipsett MB:  Pregnancies after chemotherapy of trophoblastic neoplasms . Science 169:1326-1327, 1970;.
3 +
Li FP, Jaffe N:  Progeny of childhood cancer survivors . Lancet 2:707-709, 1974;.
4 +
Sarkar SD, Beierwaltes WH, Gill SP, et al:  Subsequent fertility and birth histories of children and adolescents treated with I131 for thyroid cancer . J Nucl Med 17:460-464, 1976;.
5 +
Cohen MM, Gerbie AB, Nadler HL:  Chromosomal investigation in pregnancies following chemotherapy for choriocarcinoma . Lancet 2:219, 1971;.
6 +
Whelton JA, McSweeney DJ:  Successful pregnancy after radiation therapy for carcinoma of the cervix . Am J Obstet Gynecol 88:443-446, 1964;.
7 +
Awa AA, Bloom AD, Yoshida MC, et al:  Cytogenetic study of the offspring of atom bomb survivors . Nature 218:367-368, 1968;.
8 +
Awa AA, Honda T, Sofuni T, et al:  Chromosome-aberration frequency in cultured blood cells in relation to radiation dose of A-bomb survivors . Lancet 2:903-905, 1971;.
9 +
Holmes GE, Holmes FF:  Pregnancy outcome of patients treated for Hodgkin's disease . Cancer 41:1317-1322, 1978;.
10 +
Chapman RM, Sutcliffe SB, Rees LR, et al:  Cyclical combination chemotherapy and gonadal function: Retrospective male study . Lancet 1:285-289, 1979;.
11 +
England and Wales . Population Series FM2 No. 2 (1901-1975), London, 1975;, p 3.
12 +
Kumar R, McEvoy J, Biggart JD, et al:  Cyclophosphamide and reproductive function . Lancet 1:1212-1214, 1972;.
13 +
Udall PR, Kerr DNS, Tacchi D:  Sterility and cyclophosphamide . Lancet 1:693-694, 1972;.
14 +
Floch OL, Donaldson Sarah S, Kaplan HS:  Pregnancy following oophoropexy and total nodal irradiation in women with Hodgkin's disease . Cancer 38:2263-2268, 1976;.
15 +
Warne GL, Fairley KF, Hobbs JB, et al:  Cyclophosphamide-induced ovarian failure . N Engl J Med 289:1159-1162, 1973;.
16 +
Sobrino LG, Levine RA, DeConti RC:  Amenorrhea in patients with Hodgkin's disease treated with antineoplastic agents . Am J Obstet Gynecol 109:135-139, 1971;.
17 +
Himelstein-Braw R, Peters H, Faber H:  Influence of irradiation and chemotherapy on the ovaries of children with abdominal tumors . Br J Cancer 36:269-274, 1977;.
18 +
Rose DP, Davis TE:  Ovarian function in patients receiving adjuvant chemotherapy for breast cancer . Lancet 1:1174-1176, 1977;.
19 +
Samaan NA, DeAsis DN Jr, Buzdar AV, et al:  Pituitary-ovarian function in breast cancer patients on adjuvant chemoimmunotherapy . Cancer 41:2084-2087, 1978;.

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