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ARTICLE |

Use of Anticonvulsant Drugs FREE

Fritz E. Dreifuss, MB, MRCP, FRACP
[+] Author Affiliations

Reprint requests to Department of Neurology, University of Virginia Medical Center, Charlottesville, VA 22901 (Dr Dreifuss).


JAMA. 1979;241(6):607-609. doi:10.1001/jama.1979.03290320045033
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THE PAST decade has seen considerable changes in epilepsy management, to which the introduction of new anticonvulsant drugs has contributed. Unfortunately, the ideal drug, one that is long-acting, nonsedative, well-tolerated, useful against various types of seizures, and without a substantive effect on vital organs, while at the same time restoring the EEG to normal, does not exist.

Drugs that have been introduced into the therapy of epilepsy in recent years have tended to have more specific actions against particular seizure types, and this has necessitated a more accurate identification and classification of the epilepsies (Table).1 Thus, drugs useful against absence seizures are not useful in the treatment of complex partial seizures, which may closely mimic absence seizures, and this mandates the distinction between these different types of seizure phenomenons. The introduction of new drugs has been aided by the development of the science of biostatistics, resulting in improved study

REFERENCES

Gastaut H:  Clinical and electroencephalographic classification of epileptic seizures . Epilepsia 11:102-113, 1970;.
Penry JK:  Principles for testing of antiepileptic drugs . Epilepsia 14:451-458, 1973;.
Kutt H, Penry JK:  Usefulness of blood levels of antiepileptic drugs . Arch Neurol 31:283-288, 1974;.
Cereghino JJ, Brock JT, VanMeter JC, et al:  Carbamazepine for epilepsy . Neurology 24:401-410, 1974;.
Simon D, Penry JK:  Sodium di-n-propylacetate (DPA) in the treatment of epilepsy . Epilepsia 16:549-573, 1975;.
Jeavons PM, Clark JE, Maheshwari MC:  Treatment of generalized epilepsies of childhood and adolescence with sodium valproate (Epilim) . Dev Med Child Neurol 19:9-25, 1977;.
Penry JK, Porter RJ, Dreifuss FE:  Ethosuximide: Relation of plasma levels to clinical control , in Woodbury DM, Penry JK, Schmidt RP (eds): Antiepileptic Drugs . New York, Raven Press, 1972;, pp 431-441.
Booker HE:  Idiosyncratic reactions to antiepileptic drugs . Epilepsia 16:171-181, 1975;.
Reynolds EH:  Chronic antiepileptic toxicity: A review . Epilepsia 16:319-352, 1975;.
Dreifuss FE, Penry JK, Rose SW, et al:  Serum clonazepam concentrations in children with absence seizures . Neurology 25:255-258, 1975;.
Lombroso CT:  The treatment of status epilepticus . Pediatrics 53:536, 1974;.
Nelson KB, Ellenberg JH:  Predictors of epilepsy in children who have experienced febrile seizures . N Engl J Med 295:1029-1037, 1976;.

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Gastaut H:  Clinical and electroencephalographic classification of epileptic seizures . Epilepsia 11:102-113, 1970;.
Penry JK:  Principles for testing of antiepileptic drugs . Epilepsia 14:451-458, 1973;.
Kutt H, Penry JK:  Usefulness of blood levels of antiepileptic drugs . Arch Neurol 31:283-288, 1974;.
Cereghino JJ, Brock JT, VanMeter JC, et al:  Carbamazepine for epilepsy . Neurology 24:401-410, 1974;.
Simon D, Penry JK:  Sodium di-n-propylacetate (DPA) in the treatment of epilepsy . Epilepsia 16:549-573, 1975;.
Jeavons PM, Clark JE, Maheshwari MC:  Treatment of generalized epilepsies of childhood and adolescence with sodium valproate (Epilim) . Dev Med Child Neurol 19:9-25, 1977;.
Penry JK, Porter RJ, Dreifuss FE:  Ethosuximide: Relation of plasma levels to clinical control , in Woodbury DM, Penry JK, Schmidt RP (eds): Antiepileptic Drugs . New York, Raven Press, 1972;, pp 431-441.
Booker HE:  Idiosyncratic reactions to antiepileptic drugs . Epilepsia 16:171-181, 1975;.
Reynolds EH:  Chronic antiepileptic toxicity: A review . Epilepsia 16:319-352, 1975;.
Dreifuss FE, Penry JK, Rose SW, et al:  Serum clonazepam concentrations in children with absence seizures . Neurology 25:255-258, 1975;.
Lombroso CT:  The treatment of status epilepticus . Pediatrics 53:536, 1974;.
Nelson KB, Ellenberg JH:  Predictors of epilepsy in children who have experienced febrile seizures . N Engl J Med 295:1029-1037, 1976;.
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