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June 29, 1979, Vol 241, No. 26 >
ARTICLE | June 29, 1979

Successful Treatment of Human Genital Herpes Infections With 2-Deoxy-D-glucose FREE

Herbert A. Blough, MD; Robert L. Giuntoli, MD
[+] Author Affiliations

Read before the Herpesvirus Workshop, St John's College, Cambridge University, United Kingdom, Aug 21, 1978.

Reprint requests to Scheie Eye Institute, University of Pennsylvania, 51 N 39th St, Philadelphia, PA 19104 (Dr Blough).


JAMA. 1979;241(26):2798-2801. doi:10.1001/jama.1979.03290520022018
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References

Thirty-six women with genital herpes infections (proved by virological or cytological means) were treated in a double-blind placebo-controlled study with the glucose analogue 2-deoxy-D-glucose for a three-week period. In initial mucocutaneous cases, 89% were cured, with two recurrences after 24 months; in the case of recurrent or secondary infections, 90% had a notable improvement manifested by no or less-frequent recurrences, fewer lesions, or shortened duration of symptoms. In initial infections, discomfort cleared within 12 to 72 hours of therapy; 90% of the patients were asymptomatic within four days. In both cases, virus shedding was notably reduced by 2-deoxy-D-glucose. Concomitant controls treated with placebos failed to respond within this time frame. The use of 2-deoxy-D-glucose provides a simple and unique approach to the treatment of genital herpesvirus infections.

(JAMA 241:2798-2801, 1979)

REFERENCES

1 +
Kaufman RH, Gardner HL, Rawls WE, et al:  Clinical features of herpes genitalis . Cancer Res 33:1446-1451, 1973;.
2 +
Rotkin ID:  A comparison review of key epidemiological studies in cervical cancer related to current searches for transmissible agents . Cancer Res 33:1353-1367, 1973;.
3 +
Nahmias AJ, Naid ZM, Josey WE:  Prospective studies of the association of genital herpes simplex infection and cervical anaplasia . Cancer Res 33:1491-1503, 1973;.
4 +
Royston I, Aurelian L:  Immunofluorescent detection of herpes virus antigens in exfoliated cells from human cervical carcinoma . Proc Natl Acad Sci USA 17:204-212, 1970;.
5 +
Roizman B, Frenkel N:  The transcription and state of herpes simplex virus in productive infection and in human cervical cancer tissue . Cancer Res 33:1402-1416, 1974;.
6 +
Rapp F, Duff R:  Oncogenic conversion of normal cells by inactivated herpes simplex viruses . Cancer 34( (suppl 4) ):1353-1362, 1974;.
7 +
Kilbourne ED:  Inhibition of influenza virus multiplication with a glucose antimetabolite (2-deoxy-D-glucose) . Nature 183:271-272, 1959;.
8 +
Courtney RJ, Steiner SM, Benyesh-Melnick M:  Effects of 2-deoxy-D-glucose on herpes simplex virus replication . Virology 52:447-455, 1975;.
9 +
Gallaher WR, Levitan DB, Blough HA:  Effect of 2-deoxy-D-glucose on cell fusion induced by Newcastle disease and herpes simplex viruses . Virology 55:193-201, 1973;.
10 +
Scholtissek C:  Inhibition of the multiplication of enveloped viruses by glucose derivatives . Curr Top Microbiol Immunol 70:101-119, 1974;.
11 +
Steiner MR, Somers K, Steiner S:  Incorporation of [14C]-2-deoxy-D-glucose into the lipids of normal cells as compared to virus-transformed cells . Biochem Biophys Res Commun 61:745-751, 1974;.
12 +
Ray EK, Blough HA:  The effect of herpesvirus infections and 2-deoxy-D-glucose on glycosphingolipids in BHK-21 cells . Virology 88:118-127, 1978;.
13 +
Ray EK, Halpern BL, Levitan DB, et al:  A new approach to viral chemotherapy: Inhibitors of glycoprotein synthesis . Lancet 2:680-683, 1974;.
14 +
Levitan DB, Blough HA:  Preliminary biochemical characterization of the factor(s) responsible for herpesvirus-induced exogenous fusion . J Virol 18:1081-1087, 1976;.
15 +
Kaufman HE, Martola E, Dohlman C:  Use of 5-iodo-2′deoxyuridine (IUD) in treatment of herpes simplex keratitis . Arch Ophthalmol 68:235-239, 1962;.
16 +
Schabel FM:  The antiviral activity of 9β-D-arabinofuranosyladenine (Ara-A) . Chemotherapy 13:321-338, 1968;.
17 +
Adams RG, Benson EA, Alexander ER, et al:  Genital herpetic infection in men and women: Clinical course and effect of topical application of adenine arabinoside . J Infect Dis 133( (suppl) ):151-159, 1976;.
18 +
Kaufman HE:  In vivo studies with antiviral agents . Ann NY Acad Sci 130:168-180, 1965;.
19 +
Rapp F, Li JH, Jerkofsky M:  Transformation of mammalian cells by DNA-containing viruses following photodynamic inactivation . Virology 55:339-346, 1973;.
20 +
Courtney RJ:  Herpes simplex virus protein synthesis in the presence of 2-deoxy-D-glucose . Virology 73:286-294, 1976;.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

1 +
Kaufman RH, Gardner HL, Rawls WE, et al:  Clinical features of herpes genitalis . Cancer Res 33:1446-1451, 1973;.
2 +
Rotkin ID:  A comparison review of key epidemiological studies in cervical cancer related to current searches for transmissible agents . Cancer Res 33:1353-1367, 1973;.
3 +
Nahmias AJ, Naid ZM, Josey WE:  Prospective studies of the association of genital herpes simplex infection and cervical anaplasia . Cancer Res 33:1491-1503, 1973;.
4 +
Royston I, Aurelian L:  Immunofluorescent detection of herpes virus antigens in exfoliated cells from human cervical carcinoma . Proc Natl Acad Sci USA 17:204-212, 1970;.
5 +
Roizman B, Frenkel N:  The transcription and state of herpes simplex virus in productive infection and in human cervical cancer tissue . Cancer Res 33:1402-1416, 1974;.
6 +
Rapp F, Duff R:  Oncogenic conversion of normal cells by inactivated herpes simplex viruses . Cancer 34( (suppl 4) ):1353-1362, 1974;.
7 +
Kilbourne ED:  Inhibition of influenza virus multiplication with a glucose antimetabolite (2-deoxy-D-glucose) . Nature 183:271-272, 1959;.
8 +
Courtney RJ, Steiner SM, Benyesh-Melnick M:  Effects of 2-deoxy-D-glucose on herpes simplex virus replication . Virology 52:447-455, 1975;.
9 +
Gallaher WR, Levitan DB, Blough HA:  Effect of 2-deoxy-D-glucose on cell fusion induced by Newcastle disease and herpes simplex viruses . Virology 55:193-201, 1973;.
10 +
Scholtissek C:  Inhibition of the multiplication of enveloped viruses by glucose derivatives . Curr Top Microbiol Immunol 70:101-119, 1974;.
11 +
Steiner MR, Somers K, Steiner S:  Incorporation of [14C]-2-deoxy-D-glucose into the lipids of normal cells as compared to virus-transformed cells . Biochem Biophys Res Commun 61:745-751, 1974;.
12 +
Ray EK, Blough HA:  The effect of herpesvirus infections and 2-deoxy-D-glucose on glycosphingolipids in BHK-21 cells . Virology 88:118-127, 1978;.
13 +
Ray EK, Halpern BL, Levitan DB, et al:  A new approach to viral chemotherapy: Inhibitors of glycoprotein synthesis . Lancet 2:680-683, 1974;.
14 +
Levitan DB, Blough HA:  Preliminary biochemical characterization of the factor(s) responsible for herpesvirus-induced exogenous fusion . J Virol 18:1081-1087, 1976;.
15 +
Kaufman HE, Martola E, Dohlman C:  Use of 5-iodo-2′deoxyuridine (IUD) in treatment of herpes simplex keratitis . Arch Ophthalmol 68:235-239, 1962;.
16 +
Schabel FM:  The antiviral activity of 9β-D-arabinofuranosyladenine (Ara-A) . Chemotherapy 13:321-338, 1968;.
17 +
Adams RG, Benson EA, Alexander ER, et al:  Genital herpetic infection in men and women: Clinical course and effect of topical application of adenine arabinoside . J Infect Dis 133( (suppl) ):151-159, 1976;.
18 +
Kaufman HE:  In vivo studies with antiviral agents . Ann NY Acad Sci 130:168-180, 1965;.
19 +
Rapp F, Li JH, Jerkofsky M:  Transformation of mammalian cells by DNA-containing viruses following photodynamic inactivation . Virology 55:339-346, 1973;.
20 +
Courtney RJ:  Herpes simplex virus protein synthesis in the presence of 2-deoxy-D-glucose . Virology 73:286-294, 1976;.

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