0
March 9, 1979, Vol 241, No. 10 >
ARTICLE | March 9, 1979

Prevention of Russian Influenza by Amantadine FREE

Arnold S. Monto, MD; Robert A. Gunn, MD, MPH; Mark G. Bandyk, MS; Christopher L. King, MD
[+] Author Affiliations

Reprint requests to School of Public Health, University of Michigan, Ann Arbor, MI 48109 (Dr Monto).


JAMA. 1979;241(10):1003-1007. doi:10.1001/jama.1979.03290360019018
Text Size: A A A
Published online
Article
References

We tested the effectiveness of amantadine hydrochloride in prevention of illness and infection caused by Russian (H1N1) influenza. The trial lasted seven weeks and was double-blind and placebo controlled. The dosage used was 200 mg daily. Efficacy in prevention of serologically confirmed clinical influenza was 70.7%. Efficacy in prevention of infection, symptomatic or asymptomatic, was 39.4%. Side effects seen were all mild, began within two days of the start of the trial, and terminated rapidly on cessation of prophylaxis. The withdrawal rate attributable to use of amantadine was 6.2%. Those who continued to receive prophylaxis for the remainder of the trial did not exhibit excess side effects. It is concluded that amantadine is safe and effective in prophylaxis of H1N1 strains, as has been shown previously for other subtypes of A influenza.

(JAMA 241:1003-1007, 1979)

REFERENCES

1 +
Davies WL, Grunert RR, Haff RF, et al:  Antiviral activity of 1-adamantanamine (amantadine) . Science 144:862-863, 1964;.
2 +
Cockran KW, Maassab HF, Tsunoda A, et al:  Studies of the antiviral activity of amantadine hydrochloride . Ann NY Acad Sci 130:432-439, 1965;.
3 +
Schild GC, Sutton RNP:  Inhibition of influenza viruses in vitro and in vivo by 1-adamantanamine hydochloride . Br J Exp Pathol 46:263-273, 1965;.
4 +
Jackson GG, Muldoon RL, Akers LW:  Serologic evidence for prevention of influenzal infection in volunteers by an anti-influenzal, adamantanamine hydrochloride . Antimicrob Agents Chemother 3:703-707, 1963;.
5 +
Finklea JF, Hennessy AV, Davenport FM:  A field trial of amantadine chemoprophylaxis in acute respiratory disease . Am J Epidemiol 85:403-412, 1967;.
6 +
Quilligan JJ Jr, Hirayama M, Baernstein HD Jr:  The suppression of A2 influenza in children by the chemoprophylactic use of amantadine . J Pediatr 69:572-575, 1966;.
7 +
Sabin AB:  Amantadine hydrochloride: Analysis of data related to its proposed use for prevention of A2 influenza virus disease in human beings . JAMA 200:943-950, 1967;.
8 +
Zhdanov VM, Lvov DK, Zakstelskaya LY, et al:  Return of epidemic Al (H1N1) influenza virus . Lancet 1:294-295, 1978;.
9 +
Monto AS, Kioumehr F:  The Tecumseh study of respiratory illness: IX. Occurrence of influenza in the community, 1966-1971 . Am J Epidemiol 102:553-563, 1975;.
10 +
Jackson GG:  Sensitivity of influenza A virus to amantadine . J Infect Dis 136:301-302, 1977;.
11 +
Galbraith AW, Oxford JS, Schild GC, et al:  Protective effect of 1-adamantanamine hydrochloride on influenza A2 infections in the family environment: A controlled double-blind study . Lancet 2:1026-1028, 1969;.
12 +
Smorodintsev AA, Karpuhin GI, Zlydnikov DM, et al:  The prophylactic effectiveness of amantadine hydrochloride in an epidemic of Hong Kong influenza in Leningrad in 1969 . Bull WHO 42:865-872, 1970;.
13 +
O'Donoghue JM, Ray CG, Terry DW Jr, et al:  Prevention of nosocomial influenzal infection with amantadine . Am J Epidemiol 97:276-282, 1973;.
14 +
Jackson GG, Stanley ED:  Prevention and control of influenza by chemoprophylaxis and chemotherapy: Prospects from examination of recent experience . JAMA 235:2739-2742, 1976;.
15 +
Muldoon RL, Stanley ED, Jackson GG, et al:  Use and withdrawal of amantadine chemoprophylaxis during epidemic influenza A . Am Rev Respir Dis 113:487-491, 1976;.
16 +
Muldoon RL, Jackson GG:  Antibody response in rabbits to antigenic stimulation during amantadine treatment . Soc Exp Biol Med 126:26-30, 1967;.
17 +
Schwab RS, Poskanzer DC, England AC Jr, et al:  Amantadine in Parkinson's disease: Review of more than two years' experience . JAMA 222:792-795, 1972;.

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

1 +
Davies WL, Grunert RR, Haff RF, et al:  Antiviral activity of 1-adamantanamine (amantadine) . Science 144:862-863, 1964;.
2 +
Cockran KW, Maassab HF, Tsunoda A, et al:  Studies of the antiviral activity of amantadine hydrochloride . Ann NY Acad Sci 130:432-439, 1965;.
3 +
Schild GC, Sutton RNP:  Inhibition of influenza viruses in vitro and in vivo by 1-adamantanamine hydochloride . Br J Exp Pathol 46:263-273, 1965;.
4 +
Jackson GG, Muldoon RL, Akers LW:  Serologic evidence for prevention of influenzal infection in volunteers by an anti-influenzal, adamantanamine hydrochloride . Antimicrob Agents Chemother 3:703-707, 1963;.
5 +
Finklea JF, Hennessy AV, Davenport FM:  A field trial of amantadine chemoprophylaxis in acute respiratory disease . Am J Epidemiol 85:403-412, 1967;.
6 +
Quilligan JJ Jr, Hirayama M, Baernstein HD Jr:  The suppression of A2 influenza in children by the chemoprophylactic use of amantadine . J Pediatr 69:572-575, 1966;.
7 +
Sabin AB:  Amantadine hydrochloride: Analysis of data related to its proposed use for prevention of A2 influenza virus disease in human beings . JAMA 200:943-950, 1967;.
8 +
Zhdanov VM, Lvov DK, Zakstelskaya LY, et al:  Return of epidemic Al (H1N1) influenza virus . Lancet 1:294-295, 1978;.
9 +
Monto AS, Kioumehr F:  The Tecumseh study of respiratory illness: IX. Occurrence of influenza in the community, 1966-1971 . Am J Epidemiol 102:553-563, 1975;.
10 +
Jackson GG:  Sensitivity of influenza A virus to amantadine . J Infect Dis 136:301-302, 1977;.
11 +
Galbraith AW, Oxford JS, Schild GC, et al:  Protective effect of 1-adamantanamine hydrochloride on influenza A2 infections in the family environment: A controlled double-blind study . Lancet 2:1026-1028, 1969;.
12 +
Smorodintsev AA, Karpuhin GI, Zlydnikov DM, et al:  The prophylactic effectiveness of amantadine hydrochloride in an epidemic of Hong Kong influenza in Leningrad in 1969 . Bull WHO 42:865-872, 1970;.
13 +
O'Donoghue JM, Ray CG, Terry DW Jr, et al:  Prevention of nosocomial influenzal infection with amantadine . Am J Epidemiol 97:276-282, 1973;.
14 +
Jackson GG, Stanley ED:  Prevention and control of influenza by chemoprophylaxis and chemotherapy: Prospects from examination of recent experience . JAMA 235:2739-2742, 1976;.
15 +
Muldoon RL, Stanley ED, Jackson GG, et al:  Use and withdrawal of amantadine chemoprophylaxis during epidemic influenza A . Am Rev Respir Dis 113:487-491, 1976;.
16 +
Muldoon RL, Jackson GG:  Antibody response in rabbits to antigenic stimulation during amantadine treatment . Soc Exp Biol Med 126:26-30, 1967;.
17 +
Schwab RS, Poskanzer DC, England AC Jr, et al:  Amantadine in Parkinson's disease: Review of more than two years' experience . JAMA 222:792-795, 1972;.

Letters

Submit a Letter
CME Course for:


You need to register in order to view this quiz.


To understand the clinical management of acute heart failure syndromes.
Accreditation Information The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
To view and print your certificate and access a summary of your CME courses go to My CME.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s “Cited By” API will populate this tab (http://www.crossref.org/citedby.html).
Compression-Only CPR: Pushing the Science Forward
Cone
AAM 2010;304:1493-1495.
All you need to read in the other general journals
BMJ 2010;341:c5893-c1494.
Submit a Response

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

© 2012 American Medical Association. All Rights Reserved.
Powered bySilverchair Information Systems