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August 18, 1978, Vol 240, No. 7 >
ARTICLE | August 18, 1978

Exercise Tolerance Test: Title and subTitle BreakSingle-Sample Screening Technique to Rule Out Growth-Hormone Deficiency FREE

Roger E. Johnsonbaugh, MD, PhD; David E. Bybee, MD; Leon P. Georges, MD
[+] Author Affiliations

The views expressed herein are those of the authors and do not necessarily reflect the views of the Navy Department or the Department of Defense.

Reprint requests to Department of Pediatrics, National Naval Medical Center, Bethesda, MD 20014 (Dr Johnsonbaugh).


JAMA. 1978;240(7):664-666. doi:10.1001/jama.1978.03290070066020
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References

Parent-directed vigorous exercise was evaluated as a screening test for adequacy of pituitary growth-hormone release in 57 short-statured children. This method obviated the need for pharmacologic provocative testing in all but the four children with growth-hormone deficiency. In 92% of the euendocrine children, the immediate postexercise venous sample demonstrated an adequate growth-hormone level. Vigorous physical exercise after an 8- to 12-hour fast with a single postexercise serum growth-hormone sample is a reliable, safe, and cost-effective screening test for growth-hormone deficiency.

(JAMA 240:664-666, 1978)

REFERENCES

1 +
Roth J, Glick SM, Yalow RS, et al:  Hypoglycemia: A potent stimulus to secretion of growth hormone . Science 140:987-988, 1963;.
2 +
Merimee TJ, Lillicrap DA, Rabinowitz D:  Effect of arginine on serum-levels of human growth-hormone . Lancet 2:668-670, 1965;.
3 +
Boyd AE, Lebovitz HE, Pfeiffer JB:  Stimulation of human-growth-hormone secretion by L-DOPA . N Engl J Med 283:1425-1429, 1970;.
4 +
Gagliardino JJ, Baily JD, Martin JM:  Effect of vasopressin on serum-levels of human growth hormone . Lancet 1:1357-1358, 1967;.
5 +
Merimee TJ:  Insulin resistance: Study of effect of 6-mercaptopurine . Lancet 1:69-71, 1965;.
6 +
Zahnd GR, Nadeau A, Von Muhlendahl K:  Effect of corticotrophin on plasma levels of human growth hormone . Lancet 2:1278-1280, 1969;.
7 +
Sutton J, Lazarus L:  Growth hormone in exercise: Comparison of physiological and pharmacological stimuli . J Appl Physiol 41:523-527, 1976;.
8 +
Buckler JMH:  Exercise as a screening test for growth hormone release . Acta Endocrinol 69:219-224, 1972;.
9 +
Lacey KA, Hewison A, Parkin JM:  Exercise as a screening test for growth hormone deficiency in children . Arch Dis Child 48:508-511, 1973;.
10 +
Lin T, Tucci JR:  Provocative tests of growth hormone release . Ann Intern Med 80:464-469, 1974;.
11 +
Keenan BS, Killmer LB, Sode J:  Growth hormone response to exercise: A test of pituitary function in children . Pediatrics 50:760-764, 1972;.
12 +
Roth J, Glick SM, Yalow RS, et al:  Secretion of human groeth hormone: Physiologic and experimental modification . Metabolism 12:577-579, 1963;.
13 +
Schalch DS:  The influence of physical stress and exercise on growth hormone and insulin secretion in man . J Lab Clin Med 69:256-269, 1967;.
14 +
Johanson AJ, Morris GL:  A single growth hormone determination to rule-out growth hormone deficiency . Pediatrics 59:467-468, 1977;.
15 +
Schalch DS, Parker ML:  A sensitive double antibody immunoassay for human growth hormone in plasma . Nature 203:1141-1142, 1964;.
16 +
Frasier SD:  A review of growth hormone stimulation tests in children . Pediatrics 53:929-937, 1974;.
17 +
Youlton R, Kaplan SL, Grumbach MM:  Growth and growth hormone: IV. Limitations of the growth hormone response to insulin and arginine and of the immunoreactive insulin response to arginine in the assessment of growth hormone deficiency in children . Pediatrics 43:989-1004, 1969;.
18 +
Najjar SS, Khachadurian AK, Ilbawi NM, et al:  Dwarfism with elevated levels of plasma growth hormone . N Engl J Med 284:809-812, 1971;.
19 +
Powell GF, Vrasel JA, Blizzard RM:  Emotional deprivation and growth retardation simultating idiopathic hypopituitarism . N Engl J Med 276:1271-1278, 1967;.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

1 +
Roth J, Glick SM, Yalow RS, et al:  Hypoglycemia: A potent stimulus to secretion of growth hormone . Science 140:987-988, 1963;.
2 +
Merimee TJ, Lillicrap DA, Rabinowitz D:  Effect of arginine on serum-levels of human growth-hormone . Lancet 2:668-670, 1965;.
3 +
Boyd AE, Lebovitz HE, Pfeiffer JB:  Stimulation of human-growth-hormone secretion by L-DOPA . N Engl J Med 283:1425-1429, 1970;.
4 +
Gagliardino JJ, Baily JD, Martin JM:  Effect of vasopressin on serum-levels of human growth hormone . Lancet 1:1357-1358, 1967;.
5 +
Merimee TJ:  Insulin resistance: Study of effect of 6-mercaptopurine . Lancet 1:69-71, 1965;.
6 +
Zahnd GR, Nadeau A, Von Muhlendahl K:  Effect of corticotrophin on plasma levels of human growth hormone . Lancet 2:1278-1280, 1969;.
7 +
Sutton J, Lazarus L:  Growth hormone in exercise: Comparison of physiological and pharmacological stimuli . J Appl Physiol 41:523-527, 1976;.
8 +
Buckler JMH:  Exercise as a screening test for growth hormone release . Acta Endocrinol 69:219-224, 1972;.
9 +
Lacey KA, Hewison A, Parkin JM:  Exercise as a screening test for growth hormone deficiency in children . Arch Dis Child 48:508-511, 1973;.
10 +
Lin T, Tucci JR:  Provocative tests of growth hormone release . Ann Intern Med 80:464-469, 1974;.
11 +
Keenan BS, Killmer LB, Sode J:  Growth hormone response to exercise: A test of pituitary function in children . Pediatrics 50:760-764, 1972;.
12 +
Roth J, Glick SM, Yalow RS, et al:  Secretion of human groeth hormone: Physiologic and experimental modification . Metabolism 12:577-579, 1963;.
13 +
Schalch DS:  The influence of physical stress and exercise on growth hormone and insulin secretion in man . J Lab Clin Med 69:256-269, 1967;.
14 +
Johanson AJ, Morris GL:  A single growth hormone determination to rule-out growth hormone deficiency . Pediatrics 59:467-468, 1977;.
15 +
Schalch DS, Parker ML:  A sensitive double antibody immunoassay for human growth hormone in plasma . Nature 203:1141-1142, 1964;.
16 +
Frasier SD:  A review of growth hormone stimulation tests in children . Pediatrics 53:929-937, 1974;.
17 +
Youlton R, Kaplan SL, Grumbach MM:  Growth and growth hormone: IV. Limitations of the growth hormone response to insulin and arginine and of the immunoreactive insulin response to arginine in the assessment of growth hormone deficiency in children . Pediatrics 43:989-1004, 1969;.
18 +
Najjar SS, Khachadurian AK, Ilbawi NM, et al:  Dwarfism with elevated levels of plasma growth hormone . N Engl J Med 284:809-812, 1971;.
19 +
Powell GF, Vrasel JA, Blizzard RM:  Emotional deprivation and growth retardation simultating idiopathic hypopituitarism . N Engl J Med 276:1271-1278, 1967;.

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