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November 17, 1978, Vol 240, No. 21 >
ARTICLE | November 17, 1978

Therapy and Prophylaxis of Malaria FREE

Gordon M. Trenholme, MD; Paul E. Carson, MD
[+] Author Affiliations

Reprint requests to Section of Infectious Disease, Department of Medicine, Rush-Presbyterian St Lukes Medical Center, 1753 W Harrison, Chicago, IL 60612 (Dr Trenholme).


JAMA. 1978;240(21):2293-2295. doi:10.1001/jama.1978.03290210075039
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References

Physicians should be prepared to provide prophylactic medications for travelers to malarious areas and to treat patients with malaria. Chloroquine hydrochloride is the suppressive agent of choice for treatment of mild infections due to all species of malaria except for those due to chloroquineresistant strains of Plasmodium falciparum. For treatment of severe infections with P falciparum and for treatment of all infections due to chloroquineresistant strains of P falciparum, quinine is the suppressive agent of choice. Chloroquine is also the prophylactic agent of choice for most travelers. To prevent infection with P vivax or P ovale, primaquine must also be given. A RBC glucose-6-phosphate dehydrogenase level should be obtained before administration of primaquine. For prophylaxis of chloroquine-resistant strains of P falciparum, no completely satisfactory regimen is presently available in the United States.

(JAMA 240:2293-2295, 1978)

REFERENCES

1 +
 Malaria—United States, 1977 . Morbidity Mortality Weekly Rep 27:332-333, 1978;.
2 +
Rieckmann KH, Willerson WD, Carson PE, et al:  Effects of tetracycline against drug-resistant falciparum malaria . Proc Helminth Soc Wash 39:339-347, 1972;.
3 +
Hall AP, Doberstyn EB, Mettaprakong V, et al:  Falciparum malaria cured by quinine followed by sulfadoxine-pyrimethamine . Br Med J 2:15-17, 1975;.
4 +
Donadio JV Jr, Whelton A, Kazyak L:  Quinine therapy and peritoneal dialysis in acute renal failure complicating material hemoglobinuria . Lancet 1:375-379, 1968;.
5 +
Trenholme GM, Williams RL, Rieckmann KH, et al:  Quinine disposition during malaria and during induced fever . Clin Pharmacol Ther 19:459-467, 1976;.
6 +
Hall AP:  The treatment of malaria . Br Med J 1:323-328, 1976;.
7 +
Alving AS, Johnson CF, Tarlov AR, et al:  Mitigation of the haemolytic effect of primaquine and enhancement of its action of exoerythrocytic forms of the Chesson strains of Plasmodium vivax by intermittent regimens of drug administration . Bull WHO 22:621-631, 1960;.
8 +
Morely D, Woodland M, Cuthbertson WFJ:  Controlled trial of pyrimethamine in pregnant women in an African village . Br Med J 1:667-668, 1964;.
9 +
Hart CW, Naunton RF:  The ototoxicity of chloroquine phosphate . Arch Otolaryngol 80:407-412, 1964;.
10 +
 Fatal malaria—Minnesota . Morbidity Mortality Weekly Rep 23:381-382, 1974;.
11 +
Taggert JV, Earle DP, Berliner RW, et al:  Studies of the chemotherapy of the human malaria: III. The physiological disposition and antimalarial activity of the cinchona alkaloids . J Clin Invest 27:80-86, 1948;.
12 +
Wiselogle FY: A Survey of Antimalarial Drugs, 1941-1945 . Ann Arbor, Mich, JD Edwards, 1946;, pp 200-201.
13 +
Goodman LS, Gilman A: The Pharmacological Basis of Therapeutics , ed 2. New York, MacMillan Co Publishers, 1955;.
14 +
Trenholme GM, Williams RL, Desjardins RE, et al:  Mefloquine (WR 142, 490) in the treatment of human malaria . Science 190:792-794, 1975;.

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

1 +
 Malaria—United States, 1977 . Morbidity Mortality Weekly Rep 27:332-333, 1978;.
2 +
Rieckmann KH, Willerson WD, Carson PE, et al:  Effects of tetracycline against drug-resistant falciparum malaria . Proc Helminth Soc Wash 39:339-347, 1972;.
3 +
Hall AP, Doberstyn EB, Mettaprakong V, et al:  Falciparum malaria cured by quinine followed by sulfadoxine-pyrimethamine . Br Med J 2:15-17, 1975;.
4 +
Donadio JV Jr, Whelton A, Kazyak L:  Quinine therapy and peritoneal dialysis in acute renal failure complicating material hemoglobinuria . Lancet 1:375-379, 1968;.
5 +
Trenholme GM, Williams RL, Rieckmann KH, et al:  Quinine disposition during malaria and during induced fever . Clin Pharmacol Ther 19:459-467, 1976;.
6 +
Hall AP:  The treatment of malaria . Br Med J 1:323-328, 1976;.
7 +
Alving AS, Johnson CF, Tarlov AR, et al:  Mitigation of the haemolytic effect of primaquine and enhancement of its action of exoerythrocytic forms of the Chesson strains of Plasmodium vivax by intermittent regimens of drug administration . Bull WHO 22:621-631, 1960;.
8 +
Morely D, Woodland M, Cuthbertson WFJ:  Controlled trial of pyrimethamine in pregnant women in an African village . Br Med J 1:667-668, 1964;.
9 +
Hart CW, Naunton RF:  The ototoxicity of chloroquine phosphate . Arch Otolaryngol 80:407-412, 1964;.
10 +
 Fatal malaria—Minnesota . Morbidity Mortality Weekly Rep 23:381-382, 1974;.
11 +
Taggert JV, Earle DP, Berliner RW, et al:  Studies of the chemotherapy of the human malaria: III. The physiological disposition and antimalarial activity of the cinchona alkaloids . J Clin Invest 27:80-86, 1948;.
12 +
Wiselogle FY: A Survey of Antimalarial Drugs, 1941-1945 . Ann Arbor, Mich, JD Edwards, 1946;, pp 200-201.
13 +
Goodman LS, Gilman A: The Pharmacological Basis of Therapeutics , ed 2. New York, MacMillan Co Publishers, 1955;.
14 +
Trenholme GM, Williams RL, Desjardins RE, et al:  Mefloquine (WR 142, 490) in the treatment of human malaria . Science 190:792-794, 1975;.

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