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Botulism and Guanidine: Title and subTitle BreakTen Years Later FREE

Marcello Puggiari, MD; Michael Cherington, MD
[+] Author Affiliations

Read in part before the 24th annual meeting of the American Association of Electromyography and Electrodiagnosis, Salt Lake City, Oct 1, 1977.

Reprint requests to Department of Neurology, University of Colorado Medical Center, 4200 E Ninth Ave, Denver, CO 80262 (Dr Cherington).


JAMA. 1978;240(21):2276-2277. doi:10.1001/jama.1978.03290210058027
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Guanidine hydrochloride was introduced as an adjunct in the treatment of botulism in 1968. It has been reported to be of benefit in 39 cases and of no benefit in 13 cases. No serious side effects have occurred with the short-term therapy required in botulism. Our two cases are similar to earlier cases in that the improvement seen with guanidine therapy is most notable in ocular muscles and least notable in respiratory muscles. Electrophysiological findings again showed an increase in the amplitude of evoked muscle-action potentials after guanidine administration.

(JAMA 240:2276-2277, 1978)

REFERENCES

Cherington M, Ryan DW:  Botulism and guanidine . N Engl J Med 278:931-933, 1968;.
Cherington M:  Botulism: Ten year experience . Arch Neurol 30:432-437, 1974;.
Oh SJ:  Botulism: Electrophysiologic studies . Ann Neurol 1:481-485, 1977;.
Gutman L, Pratt L:  Pathophysiologic aspects of human botulism . Arch Neurol 33:175-179, 1976;.
Ricker R, Doll W:  Guanidinbehandlung des Botulismus . Z Neurol 198:332-341, 1970;.
Jenzer G, Munenthaler M, Ludin HP, et al:  Autonomic dysfunction in botulism B: A clinical report . Neurology 25:150-153, 1975;.
Sudre Y, Becq-Giraudon B, Boutard PH:  Le botulisme: Conduite therapeutique a propos de 36 cas . Sem Hop Paris 51:807-819, 1975;.
Oh SJ, Halsey JH, Briggs DD:  Guanidine in type B botulism . Arch Intern Med 135:726-728, 1975;.
Cherington M, Schultz D:  Effect of guanidine, germine and steroids in a case of botulism . Clin Toxicol 11:19-25, 1977;.
Radecki PL, De Lisa LA:  Serial electro-diagnostic studies in botulism-wound and ingestion. American Association of Electromyography and Electrodiagnosis , abstracted. Electroencephalogr Clin Neurophysiol , to be published.
Kauf C, Lorent JP, Mosimann J, et al:  Botulismusepidemine von Type B . Schweiz Med Wochenschr 104:677-685, 1974;.

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Cherington M, Ryan DW:  Botulism and guanidine . N Engl J Med 278:931-933, 1968;.
Cherington M:  Botulism: Ten year experience . Arch Neurol 30:432-437, 1974;.
Oh SJ:  Botulism: Electrophysiologic studies . Ann Neurol 1:481-485, 1977;.
Gutman L, Pratt L:  Pathophysiologic aspects of human botulism . Arch Neurol 33:175-179, 1976;.
Ricker R, Doll W:  Guanidinbehandlung des Botulismus . Z Neurol 198:332-341, 1970;.
Jenzer G, Munenthaler M, Ludin HP, et al:  Autonomic dysfunction in botulism B: A clinical report . Neurology 25:150-153, 1975;.
Sudre Y, Becq-Giraudon B, Boutard PH:  Le botulisme: Conduite therapeutique a propos de 36 cas . Sem Hop Paris 51:807-819, 1975;.
Oh SJ, Halsey JH, Briggs DD:  Guanidine in type B botulism . Arch Intern Med 135:726-728, 1975;.
Cherington M, Schultz D:  Effect of guanidine, germine and steroids in a case of botulism . Clin Toxicol 11:19-25, 1977;.
Radecki PL, De Lisa LA:  Serial electro-diagnostic studies in botulism-wound and ingestion. American Association of Electromyography and Electrodiagnosis , abstracted. Electroencephalogr Clin Neurophysiol , to be published.
Kauf C, Lorent JP, Mosimann J, et al:  Botulismusepidemine von Type B . Schweiz Med Wochenschr 104:677-685, 1974;.
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