0
ARTICLE |

An Element of Pleasure FREE

Samuel Vaisrub, MD
JAMA. 1978;240(20):2189-2189. doi:10.1001/jama.1978.03290200067030
Text Size: A A A
Published online

Medicinal uses of zinc, which began centuries ago with the fumbling empiricism of local therapy for wounds and various skin lesions, is now entering an era of oral and parenteral therapy based on indications of specific deficiency in need of replenishment. Zinc has proved effective in acrodermatitis enteropathica of genetic origin1 as well as in the acquired variant associated with prolonged intravenous alimentation.2 Watery diarrhea and skin lesions characteristic of these zincdepleted states have responded well to replacement therapy as have the syndrome of growth retardation and hypogonadism reported from the Middle East3 and in similar malfunctions complicating sickle cell disease.4 Improvement with zinc has also been noted in refractory cases of celiac disease5 and in children with protein-energy malnutrition whose zinc-deficient state is associated with thymic atrophy and susceptibility to infection.6 True to its first love, the skin, zinc still maintains its precarious contact

REFERENCES

Moynahan EJ:  Acrodermatitis enteropathica: A lethal inherited human zinc-deficiency disorder . Lancet 2:399-400, 1974;.
Tasman-Jones C, Kay RG:  Zinc deficiency and skin lesions . N Engl J Med 293:830, 1975;.
Prasad AS, Halstead JA, Nadimi M:  Syndrome of iron deficiency anemia, hepatosplenomegaly, hypogonadism, dwarfism and geophagia . Am J Med 31:532-546, 1961;.
Prasad AS, Schoomaker EB, Ortega J, et al:  Zinc deficiency in sickle cell disease . Clin Chem 21:582-587, 1975;.
Elmes MF, Golden M, Love AHG:  Unresponsive coeliac disease . QJ Med 45:696-697, 1974;.
Golden MH, Jackson AA, Golden BF:  Effect of zinc on thymus of recently malnourished children . Lancet 2:1057-1059, 1977;.
Henkin RI, Schechter PJ, Hoye R, et al:  Idiopathic hypogeusia with dysgeusia, hyposmia, and dysosmia: A new syndrome . JAMA 217:434-440, 1971;.
Antoniou LD, Sudhakar T, Shalhoub RJ, et al:  Reversal of uraemic impotence by zinc . Lancet 2:895-898, 1977;.

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

Moynahan EJ:  Acrodermatitis enteropathica: A lethal inherited human zinc-deficiency disorder . Lancet 2:399-400, 1974;.
Tasman-Jones C, Kay RG:  Zinc deficiency and skin lesions . N Engl J Med 293:830, 1975;.
Prasad AS, Halstead JA, Nadimi M:  Syndrome of iron deficiency anemia, hepatosplenomegaly, hypogonadism, dwarfism and geophagia . Am J Med 31:532-546, 1961;.
Prasad AS, Schoomaker EB, Ortega J, et al:  Zinc deficiency in sickle cell disease . Clin Chem 21:582-587, 1975;.
Elmes MF, Golden M, Love AHG:  Unresponsive coeliac disease . QJ Med 45:696-697, 1974;.
Golden MH, Jackson AA, Golden BF:  Effect of zinc on thymus of recently malnourished children . Lancet 2:1057-1059, 1977;.
Henkin RI, Schechter PJ, Hoye R, et al:  Idiopathic hypogeusia with dysgeusia, hyposmia, and dysosmia: A new syndrome . JAMA 217:434-440, 1971;.
Antoniou LD, Sudhakar T, Shalhoub RJ, et al:  Reversal of uraemic impotence by zinc . Lancet 2:895-898, 1977;.
CME Course for:


You need to register in order to view this quiz.


To understand the clinical management of acute heart failure syndromes.
Accreditation Information The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
To view and print your certificate and access a summary of your CME courses go to My CME.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s “Cited By” API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Response

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.