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November 10, 1978, Vol 240, No. 20 >
ARTICLE | November 10, 1978

Hypocupremia Induced by Zinc Therapy in Adults FREE

Ananda S. Prasad, MD, PhD; George J. Brewer, MD; Eric B. Schoomaker, MD; Parviz Rabbani, PhD
[+] Author Affiliations

Reprint requests to Department of Medicine, Wayne State University School of Medicine, 540 E Canfield Ave, Detroit, Ml 48201 (Dr Prasad).


JAMA. 1978;240(20):2166-2168. doi:10.1001/jama.1978.03290200044019
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References

Hypocupremia occurred in an adult with sickle cell anemia who received zinc as an antisickling agent for two years. The hypocupremia was associated with microcytosis and relative neutropenia. Administration of copper resulted in an increase in RBC size and leukocyte counts. We have since observed hypoceruloplasminemia of varying degrees in several other sickle cell anemia patients who were receiving oral zinc therapy. This complication was easily corrected by copper supplementation.

(JAMA 240:2166-2168, 1978)

REFERENCES

1 +
Wintrobe MM: Clinical Hematology , ed 7. Philadelphia, Lea & Febiger Publishers, 1974;, p 150.
2 +
Graham GG, Cordano A:  Copper deficiency in human subjects , in Prasad AS (ed): Trace Elements in Human Health and Disease. New York, Academic Press Inc, 1976;, vol 1, pp 363-372.
3 +
Dunlap WM, James GW, Hume DM:  Anemia and neutropenia caused by copper deficiency . Ann Intern Med 80:470-476, 1974;.
4 +
Vilter RW, Bozian RC, Hess EV, et al:  Manifestations of copper deficiency in a patient with systemic sclerosis on intravenous hyperalimentation . N Engl J Med 291:188-191, 1974;.
5 +
Prasad AS, Schoomaker EB, Ortega J, et al:  Zinc deficiency in sickle cell disease . Clin Chem 21:582-587, 1975;.
6 +
Davidsohn I, Henry JB: Todd Sanford Clinical Diagnosis by Laboratory Methods , ed 15. Philadelphia, WB Saunders Co, 1974;, p 656.
7 +
Brewer GJ, Brewer LF, Prasad AS:  Suppression of irreversibly sickled erythrocytes by zinc therapy in sickle cell anemia . J Lab Clin Med 90:549-554, 1977;.
8 +
Prasad AS, Ortega J, Brewer GJ, et al:  Trace elements in sickle cell disease . JAMA 235:2396-2398, 1976;.
9 +
Hill CH:  Mineral interrelationships , in Prasad AS (ed): Trace Elements in Human Health and Disease . New York, Academic Press Inc, 1976;, vol 2, pp 281-300.
10 +
Prasad AS:  Zinc in human nutrition . CRC Crit Rev Clin Lab Sci 8:1-80, 1977;.
11 +
Underwood EJ: Trace Elements in Human and Animal Nutrition , ed 4. New York, Academic Press Inc, 1977;, pp 56-108.
12 +
Klingberg WG, Prasad AS, Oberleas D:  Zinc deficiency following penicillamine therapy , in Prasad AS (ed): Trace Elements in Human Health and Disease. New York, Academic Press Inc, 1976;, vol 1, pp 51-66.

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1 +
Wintrobe MM: Clinical Hematology , ed 7. Philadelphia, Lea & Febiger Publishers, 1974;, p 150.
2 +
Graham GG, Cordano A:  Copper deficiency in human subjects , in Prasad AS (ed): Trace Elements in Human Health and Disease. New York, Academic Press Inc, 1976;, vol 1, pp 363-372.
3 +
Dunlap WM, James GW, Hume DM:  Anemia and neutropenia caused by copper deficiency . Ann Intern Med 80:470-476, 1974;.
4 +
Vilter RW, Bozian RC, Hess EV, et al:  Manifestations of copper deficiency in a patient with systemic sclerosis on intravenous hyperalimentation . N Engl J Med 291:188-191, 1974;.
5 +
Prasad AS, Schoomaker EB, Ortega J, et al:  Zinc deficiency in sickle cell disease . Clin Chem 21:582-587, 1975;.
6 +
Davidsohn I, Henry JB: Todd Sanford Clinical Diagnosis by Laboratory Methods , ed 15. Philadelphia, WB Saunders Co, 1974;, p 656.
7 +
Brewer GJ, Brewer LF, Prasad AS:  Suppression of irreversibly sickled erythrocytes by zinc therapy in sickle cell anemia . J Lab Clin Med 90:549-554, 1977;.
8 +
Prasad AS, Ortega J, Brewer GJ, et al:  Trace elements in sickle cell disease . JAMA 235:2396-2398, 1976;.
9 +
Hill CH:  Mineral interrelationships , in Prasad AS (ed): Trace Elements in Human Health and Disease . New York, Academic Press Inc, 1976;, vol 2, pp 281-300.
10 +
Prasad AS:  Zinc in human nutrition . CRC Crit Rev Clin Lab Sci 8:1-80, 1977;.
11 +
Underwood EJ: Trace Elements in Human and Animal Nutrition , ed 4. New York, Academic Press Inc, 1977;, pp 56-108.
12 +
Klingberg WG, Prasad AS, Oberleas D:  Zinc deficiency following penicillamine therapy , in Prasad AS (ed): Trace Elements in Human Health and Disease. New York, Academic Press Inc, 1976;, vol 1, pp 51-66.

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