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Cystic Fibrosis: Title and subTitle BreakProblems Encountered With Sweat Testing FREE

Beryl J. Rosenstein, MD; Terry S. Langbaum; Ellen Gordes; Saul W. Brusilow, MD
[+] Author Affiliations

Reprint requests to The Johns Hopkins Hospital, Park 2, 601 N Broadway, Baltimore, MD 21205 (Dr Rosenstein).


JAMA. 1978;240(18):1987-1988. doi:10.1001/jama.1978.03290180061029
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The sweat test is the only practical and reliable laboratory test for confirmation of the diagnosis of cystic fibrosis. Among 234 patients referred to The Johns Hopkins Hospital for sweat testing, 62 had had a previous test; 29 tests had been reported as negative, and 33 tests had been reported as positive. Results of quantitative pilocarpine-iontophoresis sweat tests at this center led to a change in diagnosis in 27 (43.5%) of these 62 patients. Most of the errors were false-positive.

(JAMA 240:1987-1988, 1978)

REFERENCES

Wood RE, Boat TF, Doershuk CF:  Cystic fibrosis . Am Rev Respir Dis 113:833-878, 1976;.
Darling RC, di Sant'Agnese PA, Perera GA, et al:  Electrolyte abnormalities of the sweat in fibrocystic disease of the pancreas . Am J Med Sci 225:67-70, 1953;.
Gibson LE, Cooke RE:  A test for concentration of electrolytes in sweat in cystic fibrosis of the pancreas utilizing pilocarpine by iontophoresis . Pediatrics 23:545-549, 1959;.
 Evaluation of Testing for Cystic Fibrosis: Report of the Committee for a Study for Evaluation of Testing for Cystic Fibrosis . J Pediatr 88( (pt 2) ):711-750, 1976;.
Kopito L, Shwachman H:  Studies in cystic fibrosis: Determination of sweat electrolytes in situ with direct reading electrodes . Pediatrics 43:794-798, 1969;.
Shwachman H, Mahmoodian A, Kopito L, et al:  A standard procedure for measuring conductivity of sweat as a diagnostic test for cystic fibrosis . J Pediatr 66:432-434, 1965;.
Problems in Sweat Testing , GAP Conference Report, Cystic Fibrosis Foundation, Atlanta, 1975;.
MacLean WC Jr, Tripp RW:  Cystic fibrosis with edema and falsely negative sweat test . J Pediatr 83:86-88, 1973;.
Gibson LE:  The decline of the sweat test: Comments on pitfalls and reliability . Clin Pediatr 12:450-453, 1973;.
Bray PT, Clark GCF, Moody GJ, et al:  Sweat testing for cystic fibrosis: Errors associated with the in-situ sweat test using chloride ion selective electrodes . Clin Chim Acta 80:333-338, 1977;.
Waring WW:  Current management of cystic fibrosis . Adv Pediatr 23:401-438, 1976;.

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Wood RE, Boat TF, Doershuk CF:  Cystic fibrosis . Am Rev Respir Dis 113:833-878, 1976;.
Darling RC, di Sant'Agnese PA, Perera GA, et al:  Electrolyte abnormalities of the sweat in fibrocystic disease of the pancreas . Am J Med Sci 225:67-70, 1953;.
Gibson LE, Cooke RE:  A test for concentration of electrolytes in sweat in cystic fibrosis of the pancreas utilizing pilocarpine by iontophoresis . Pediatrics 23:545-549, 1959;.
 Evaluation of Testing for Cystic Fibrosis: Report of the Committee for a Study for Evaluation of Testing for Cystic Fibrosis . J Pediatr 88( (pt 2) ):711-750, 1976;.
Kopito L, Shwachman H:  Studies in cystic fibrosis: Determination of sweat electrolytes in situ with direct reading electrodes . Pediatrics 43:794-798, 1969;.
Shwachman H, Mahmoodian A, Kopito L, et al:  A standard procedure for measuring conductivity of sweat as a diagnostic test for cystic fibrosis . J Pediatr 66:432-434, 1965;.
Problems in Sweat Testing , GAP Conference Report, Cystic Fibrosis Foundation, Atlanta, 1975;.
MacLean WC Jr, Tripp RW:  Cystic fibrosis with edema and falsely negative sweat test . J Pediatr 83:86-88, 1973;.
Gibson LE:  The decline of the sweat test: Comments on pitfalls and reliability . Clin Pediatr 12:450-453, 1973;.
Bray PT, Clark GCF, Moody GJ, et al:  Sweat testing for cystic fibrosis: Errors associated with the in-situ sweat test using chloride ion selective electrodes . Clin Chim Acta 80:333-338, 1977;.
Waring WW:  Current management of cystic fibrosis . Adv Pediatr 23:401-438, 1976;.
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