To the Editor.— We have obtained data indicating that intrauterine growth retardation is characteristic of osteogenesis imperfecta congenita (OIC) but not osteogenesis imperfecta tarda (OIT). This observation could, if confirmed after additional investigations, prove useful for diagnosis and genetic counseling.Our sample consisted of 31 infants with OIT and 20 with OIC studied at Northwestern University Medical School and the University of Louisville Medical School. The diagnosis of OIC was applied only if an infant showed shortened upper and lower extremities, multiple fractures, bowing of the extremities, blue sclerae, and caput membranaceum at birth. By contrast, all infants with OIT were said to be normal at birth, and none experienced a fracture before 3 months of age.The mean birth weight was 2,625± 117 g (SE) in OIC and 3,259±104 g in OIT. These weights were age-adjusted by use of intrauterine weight charts of Battaglia and Lubchenco.1 A nonparametric
Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature
Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal
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