Single-Dose Tetracycline Therapy for Shigellosis in Adults FREE

Larry K. Pickering, MD; Herbert L. DuPont, MD; Jorge Olarte, DSc

[+] Author Affiliations

Reprint requests to Program in Infectious Diseases and Clinical Microbiology, University of Texas Medical School, 6400 W Cullen St, Houston, TX 77030 (Dr Pickering).

JAMA. 1978;239(9):853-854. doi:10.1001/jama.1978.03280360049018

Text Size: A A A

Published online

Article

References

ABSTRACT

ABSTRACT | REFERENCES

Forty-two adults who had Shigella isolated from stool (26 symptomatic, 16 asymptomatic) received a single oral dose of tetracycline hydrochloride (2.5 g). Minimal inhibitory concentrations of the 42 isolates demonstrated that 41% were sensitive to tetracycline. Sixteen of 18 patients with diarrhea who had tetracycline-resistant Shigella and all eight patients with diarrhea who had tetracycline-sensitive Shigella were clinically well and had Shigella-negative stools 48 hours after therapy. Fifteen of 16 asymptomatic patients demonstrated clearing of Shigella from stool within 48 hours of therapy. Single-dose tetracycline therapy is effective in the treatment of Shigella regardless of clinical expression of illness or in vitro sensitive of the organism.

(JAMA 239:853-854, 1978)

REFERENCES

ABSTRACT | REFERENCES

Pickering LK, DuPont HL, Evans DG, et al: Isolation of enteric pathogens in asymptomatic US and Latin American students . J Infect Dis 135:1003-1005, 1977;.

DuPont HL, Evans DG, Pickering LK, et al: Clinical comparison of toxigenic Escherichia coli diarrhea and shigellosis , abstracted. New Orleans, Annual American Society for Microbiology, (May) 1977;.

Byers PA, DuPont HL, Goldschmidt MD: Antimicrobial susceptibilities of shigellae isolated in Houston, Texas, in 1974 . Antimicrob Agents Chemother 9:288-291, 1976;.

Garfinkel BT, Martin GM, Watt J, et al: Antibiotics in acute bacillary dysentery: Observations in 1,408 cases with positive cultures . JAMA 151:1157-1159, 1953;.

Lionel NDW, Goonewardena CV, Abeyasekera FJB, et al: A comparison of a single dose and a five-day course of tetracycline therapy in bacillary dysentery . J Trop Med Hyg 72:170-172, 1969;.

DuPont HL, Olarte J, Evans DG, et al: Comparative susceptibility of Latin American and United States students to enteric pathogens . N Engl J Med 292:1520-1521, 1976;.

Cheever FS: Treatment of shigellosis with antibiotics . Ann NY Acad Sci 55:1063-1069, 1952;.

Haltalin KC, Nelson JD, Ring R, et al: Double-blind treatment study of shigellosis comparing ampicillin, sulfadiazine, and placebo . J Pediatr 70:970-981, 1967;.

Haltalin KC, Kusmiesz HT, Hinton LV, et al: Treatment of acute diarrhea in outpatients . Am J Dis Child 124:554-561, 1972;.

DuPont HL, Hornick RB: Clinical approach to infectious diarrheas . Medicine 52:265-270, 1973;.

Yaffe SJ, Bierman CW, Cann HM, et al: Requiem for tetracyclines . Pediatrics 55:142-143, 1975;.

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal