This article is one of a series sponsored by the American Heart Association, edited by C. Richard Conti, MD.
Reprint requests to Division of Cardiovascular Medicine, PO Box J-277, J. Hillis Miller Health Center, Gainesville, FL 32610 (Dr Mehta).
DURING the last few years, there has been a great deal of interest in vasodilator therapy in cases of acute and chronic heart failure. Better understanding of cardiac physiology and development of bedside hemodynamic monitoring techniques using flowdirected catheters have provided impetus to evaluate different physiologic and pharmacologic interventions in acutely ill patients. Most patients with congestive heart failure have elevation of the left ventricular filling pressure (LVFP) and low cardiac output. Elevated LVFP (index of blood volume) is a compensatory phenomenon in the early stage of heart failure to maintain cardiac output. This beneficial effect may later result in excessive myocardial oxygen demand, decreased coronary flow, and symptoms of pulmonary congestion. Similarly, arterial constriction occurring initially in heart failure may be appropriate to maintain circulation to vital organs, but may eventually result in a decrease in cardiac output because of the elevated systemic vascular resistance.1
Experimental evidence shows
Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature
Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal
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