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July 11, 1977, Vol 238, No. 2 >
ARTICLE | July 11, 1977

Evaluation of a New Antihypertensive Agent: Title and subTitle BreakPrazosin Hydrochloride (Minipress) FREE

Mary Ellen Kosman, PhD
[+] Author Affiliations

Scientific data on prazosin hydrochloride were supplied by Pfizer Laboratories Division, Pfizer Inc, New York.

Reprint requests to Department of Drugs, American Medical Association, 535 N Dearborn, Chicago, IL 60610 (Dr Kosman).


JAMA. 1977;238(2):157-159. doi:10.1001/jama.1977.03280020061029
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References

Prazosin hydrochloride is an orally administered vasodilator that recently became available for the treatment of hypertension. It causes less tachycardia than hydralazine but may produce orthostatic hypotension, particularly after the initial dose. The role of prazosin in therapy is limited because of the risk of a first-dose syncopal reaction, and it appears to be indicated primarily in patients who cannot tolerate hydralazine hydrochloride or sympathetic depressant drugs. Like other antihypertensive agents, prazosin should be given with a diuretic.

(JAMA 238:157-159, 1977)

REFERENCES

1 +
Pitts NE:  Clinical evaluation of prazosin hydrochloride, a new antihypertensive agent , in Cotton DWK (ed): Prazosin: Evaluation of a New Antihypertensive Agent . Amsterdam, Excerpta Medica, 1974;, pp 149-163.
2 +
Smith IS, Fernandes M, Kim KE, et al: Three-phase clinical evaluation of prazosin, in Prazosin Clinical Symposium Proceedings . Minneapolis, Postgraduate Medicine, 1975;, pp 53-60.
3 +
Kincaid-Smith P, Hua ASP, Myers JB, et al:  Prazosin and hydralazine in treatment of hypertension . Clin Sci Mol Med 51( (suppl 3) ):617-619, 1976;.
4 +
Mroczek WJ, Finnerty FA:  Prazosin in hypertension: Double-blind evaluation , in Cotton DWK (ed): Prazosin: Evaluation of a New Antihypertensive Agent. Amsterdam , Excerpta Medica, 1974;, pp 92-99.
5 +
Lung-Johansen P:  Hemodynamic changes at rest and during exercise in long-term prazosin therapy for essential hypertension , in Prazosin Clinical Symposium Proceedings . Minneapolis, Postgraduate Medicine, 1975;, pp 45-52.
6 +
Falase AD, Salako LA, Aminu JM:  Lack of effect of low doses of prazosin in hypertensive Nigerians . Curr Ther Res 19:603-611, 1976;.
7 +
Bolli P, Wood AJ, Simpson F:  Effects of prazosin in patients with hypertension . Clin Pharmacol Ther 20:138-141, 1976;.
8 +
Stokes GS, Weber MA: Prazosin:  Preliminary report and comparative studies with other antihypertensive agents . Br Med J 2:298-300, 1974;.
9 +
Curtis JR, Bateman FJA:  Use of prazosin in management of hypertension in patients with chronic renal failure and in renal transplant recipients . Br Med J 4:432-434, 1975;.
10 +
Hua ASP, MacDonald IM, Myers JB, et al:  Studies with prazosin—new effective hypotensive agent: Open clinical study of prazosin in combination with other antihypertensive agents . Med J Aust 1:559-561, 1976;.
11 +
Graham RM, Thornell IR, Gain JM, et al:  Prazosin: The first-dose phenomenon . Br Med J 2:1293-1294, 1976;.
12 +
Turner AS:  Prazosin in hypertension . Br Med J 2:1257-1258, 1976;.
13 +
Rosendorff C: Prazosin:  Severe side effects are dose-dependent . Br Med J 2:508-509, 1976;.
14 +
Bendall MJ, Baloch KH, Wilson PR:  Side effects due to treatment of hypertension with prazosin . Br Med J 2:728-729, 1975;.
15 +
 Drug treatment of ambulatory patients with hypertension, COMMITTEE ON HYPERTENSIO N. JAMA 225:1647-1653, 1973;.
16 +
Constantine JW, McShane WK, Scriabine A, et al:  Analysis of hypotensive action of prazosin , in Onesti G, Kim KE, Moyer JH (eds): Hypertension: Mechanisms and Management . New York, Grune & Stratton Inc, 1973;, pp 429-444.
17 +
Hess HJ:  Biochemistry and structure-activity studies with prazosin , in Cotton DWK (ed): Prazosin: Evaluation of a New Antihypertensive Agent . Amsterdam, Excerpta Medica, 1974;, pp 3-15.
18 +
Massingham R, Hayden ML:  Comparison of effects of prazosin and hydralazine on blood pressure, heart rate and plasma renin activity in conscious renal hypertensive dogs . Eur J Pharmacol 30:121-124, 1975;.
19 +
Nickerson M, Ruedy I:  Antihypertensive agents and drug therapy of hypertension , in Goodman LS, Gilman A (eds): The Pharmacological Basis of Therapeutics , ed 5. New York, Macmillan Co Publishers, 1975;, pp 705-726.
20 +
Graham RM, Muir MR, Hayes JM:  Differing effects of vasodilator drugs, prazosin and diazoxide on plasma renin activity in the dog . Clin Exp Pharmacol Physiol 3:173-177, 1976;.

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1 +
Pitts NE:  Clinical evaluation of prazosin hydrochloride, a new antihypertensive agent , in Cotton DWK (ed): Prazosin: Evaluation of a New Antihypertensive Agent . Amsterdam, Excerpta Medica, 1974;, pp 149-163.
2 +
Smith IS, Fernandes M, Kim KE, et al: Three-phase clinical evaluation of prazosin, in Prazosin Clinical Symposium Proceedings . Minneapolis, Postgraduate Medicine, 1975;, pp 53-60.
3 +
Kincaid-Smith P, Hua ASP, Myers JB, et al:  Prazosin and hydralazine in treatment of hypertension . Clin Sci Mol Med 51( (suppl 3) ):617-619, 1976;.
4 +
Mroczek WJ, Finnerty FA:  Prazosin in hypertension: Double-blind evaluation , in Cotton DWK (ed): Prazosin: Evaluation of a New Antihypertensive Agent. Amsterdam , Excerpta Medica, 1974;, pp 92-99.
5 +
Lung-Johansen P:  Hemodynamic changes at rest and during exercise in long-term prazosin therapy for essential hypertension , in Prazosin Clinical Symposium Proceedings . Minneapolis, Postgraduate Medicine, 1975;, pp 45-52.
6 +
Falase AD, Salako LA, Aminu JM:  Lack of effect of low doses of prazosin in hypertensive Nigerians . Curr Ther Res 19:603-611, 1976;.
7 +
Bolli P, Wood AJ, Simpson F:  Effects of prazosin in patients with hypertension . Clin Pharmacol Ther 20:138-141, 1976;.
8 +
Stokes GS, Weber MA: Prazosin:  Preliminary report and comparative studies with other antihypertensive agents . Br Med J 2:298-300, 1974;.
9 +
Curtis JR, Bateman FJA:  Use of prazosin in management of hypertension in patients with chronic renal failure and in renal transplant recipients . Br Med J 4:432-434, 1975;.
10 +
Hua ASP, MacDonald IM, Myers JB, et al:  Studies with prazosin—new effective hypotensive agent: Open clinical study of prazosin in combination with other antihypertensive agents . Med J Aust 1:559-561, 1976;.
11 +
Graham RM, Thornell IR, Gain JM, et al:  Prazosin: The first-dose phenomenon . Br Med J 2:1293-1294, 1976;.
12 +
Turner AS:  Prazosin in hypertension . Br Med J 2:1257-1258, 1976;.
13 +
Rosendorff C: Prazosin:  Severe side effects are dose-dependent . Br Med J 2:508-509, 1976;.
14 +
Bendall MJ, Baloch KH, Wilson PR:  Side effects due to treatment of hypertension with prazosin . Br Med J 2:728-729, 1975;.
15 +
 Drug treatment of ambulatory patients with hypertension, COMMITTEE ON HYPERTENSIO N. JAMA 225:1647-1653, 1973;.
16 +
Constantine JW, McShane WK, Scriabine A, et al:  Analysis of hypotensive action of prazosin , in Onesti G, Kim KE, Moyer JH (eds): Hypertension: Mechanisms and Management . New York, Grune & Stratton Inc, 1973;, pp 429-444.
17 +
Hess HJ:  Biochemistry and structure-activity studies with prazosin , in Cotton DWK (ed): Prazosin: Evaluation of a New Antihypertensive Agent . Amsterdam, Excerpta Medica, 1974;, pp 3-15.
18 +
Massingham R, Hayden ML:  Comparison of effects of prazosin and hydralazine on blood pressure, heart rate and plasma renin activity in conscious renal hypertensive dogs . Eur J Pharmacol 30:121-124, 1975;.
19 +
Nickerson M, Ruedy I:  Antihypertensive agents and drug therapy of hypertension , in Goodman LS, Gilman A (eds): The Pharmacological Basis of Therapeutics , ed 5. New York, Macmillan Co Publishers, 1975;, pp 705-726.
20 +
Graham RM, Muir MR, Hayes JM:  Differing effects of vasodilator drugs, prazosin and diazoxide on plasma renin activity in the dog . Clin Exp Pharmacol Physiol 3:173-177, 1976;.

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