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ARTICLE |

Elevated Platelet-Associated IgG in Thrombotic Thrombocytopenic Purpura FREE

Lt Comdr John Morrison, MC; Robert McMillan, MD
[+] Author Affiliations

The opinions or assertions expressed herein are those of the authors and are not to be construed as official or as reflecting the views of the Navy Department or the naval service at large.

Reprint requests to Department of Internal Medicine, Naval Regional Medical Center, San Diego, CA 92134 (Dr Morrison).


JAMA. 1977;238(18):1944-1945. doi:10.1001/jama.1977.03280190046027
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A 41-year-old woman with thrombotic thrombocytopenic purpura (TTP) was treated with prednisone and splenectomy with complete recovery from her illness. Analysis of the patient's platelets for immunoglobulins showed abnormally elevated levels in the range of those seen in thrombocytopenic patients with systemic lupus erythematosus, immune vasculitis, and infectious mononucleosis. This finding is consistent with the concept that the immune system may play a role in the pathogenesis of TTP.

(JAMA 238:1944-1945, 1977)

REFERENCES

Ambrosi EL, Ultmann JE:  Thrombotic thrombocytopenic purpura: Report of 16 cases and review of the literature . Medicine 45:139-159, 1966;.
Luiken GA, McMillan R, Lightsey AL, et al:  Platelet-associated IgG in immune thrombocytopenic purpura . Blood , to be published.
McMillan R, Luiken GA, Bakich MJ, et al:  Platelet-associated IgG—an assay for immunemediated thrombocytopenia , in: Platelet Workshop . Philadelphia, 1976;, to be published.
Dixon RH, Rosse W, Ehbert L:  Quantitative determination of antibody in idiopathic thrombocytopenic purpura: Correlation of serum and platelet-bound antibody with clinical response . N Engl J Med 292:230-236, 1975;.
Dixon RH, Rosse WF:  Platelet antibody in autoimmune thrombocytopenia . Br J Haematol 31:129-134, 1975;.
Brain MC:  The hemolytic-uremic syndrome . Semin Hematol 6:162-180, 1969;.
Pitney WR:  Disseminated intravascular coagulation . Hematology 8:65-79, 1971;.
Nyllyla G:  Aggregation of human blood platelets by immune complexes in the sedimentation pattern test . Scand J Haematol , (suppl 19) , 1973;, pp 7-52.
Neame PB, Lechago J, Ling ET, et al:  Thrombotic thrombocytopenic purpura: Report of a case with disseminated intravascular platelet aggregation . Blood 42:805-814, 1973;.
Walsh PN:  Platelet coagulant activities and hemostasis: A hypothesis . Blood 43:597-605, 1974;.

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Ambrosi EL, Ultmann JE:  Thrombotic thrombocytopenic purpura: Report of 16 cases and review of the literature . Medicine 45:139-159, 1966;.
Luiken GA, McMillan R, Lightsey AL, et al:  Platelet-associated IgG in immune thrombocytopenic purpura . Blood , to be published.
McMillan R, Luiken GA, Bakich MJ, et al:  Platelet-associated IgG—an assay for immunemediated thrombocytopenia , in: Platelet Workshop . Philadelphia, 1976;, to be published.
Dixon RH, Rosse W, Ehbert L:  Quantitative determination of antibody in idiopathic thrombocytopenic purpura: Correlation of serum and platelet-bound antibody with clinical response . N Engl J Med 292:230-236, 1975;.
Dixon RH, Rosse WF:  Platelet antibody in autoimmune thrombocytopenia . Br J Haematol 31:129-134, 1975;.
Brain MC:  The hemolytic-uremic syndrome . Semin Hematol 6:162-180, 1969;.
Pitney WR:  Disseminated intravascular coagulation . Hematology 8:65-79, 1971;.
Nyllyla G:  Aggregation of human blood platelets by immune complexes in the sedimentation pattern test . Scand J Haematol , (suppl 19) , 1973;, pp 7-52.
Neame PB, Lechago J, Ling ET, et al:  Thrombotic thrombocytopenic purpura: Report of a case with disseminated intravascular platelet aggregation . Blood 42:805-814, 1973;.
Walsh PN:  Platelet coagulant activities and hemostasis: A hypothesis . Blood 43:597-605, 1974;.
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