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ARTICLE |

Hyperthyroidism From Thyroid Metastasis of Pancreatic Adenocarcinoma FREE

Margareta Eriksson, MD; Suriander K. Ajmani, MD; Lawrence E. Mallette, MD, PhD
[+] Author Affiliations

Reprint requests to Medical Service (111E), Veterans Administration Hospital, Houston, TX 77211 (Dr Mallette).


JAMA. 1977;238(12):1276-1278. doi:10.1001/jama.1977.03280130058019
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A nontender goiter rapidly developed in a 54-year-old patient with suspected disseminated carcinoma. Thyroid function tests showed increased thyroxine, triiodothyronine resin uptake, free thyroxine index, and free thyroxine. Radioactive iodine uptake by the gland was near zero, and thyroid-stimulating hormone (TSH) was undetectable. Histologic examination of the thyroid before and after death showed invasion and disruption of the thyroid follicles by adenocarcinoma (pancreatic primary). Release of thyroglobulin by follicular disruption probably resulted in hyperthyroxinemia and suppression of TSH and radioactive iodine uptake, as occurs in subacute thyroiditis.

(JAMA 238:1276-1278, 1977)

REFERENCES

Willis RA: The Spread of Tumors in the Human Body , ed 2. London, Butterworth and Co Ltd, 1952;, pp 271-275.
Shimaoka K, Sokal JE, Pickren JW:  Metastatic neoplasms of the thyroid gland: Pathological and clinical findings . Cancer 15:557-565, 1962;.
Gowing NFC:  The pathology and natural history of thyroid tumors . Neoplastic Diseases at Various Sites 6:103-129, 1970;.
Silverberg SG, Vidone RA:  Metastatic tumors in the thyroid . Pacific Med Surg 74:175-180, 1966;.
Guerrier Y, Nghiem TN:  Metastases thyroidiennes des tumeurs cellules claires du rein . J Franc Otorhinolaryngol 14:5-20, 1965;.
Sirota DK, Goldfield EB, Eng YF, et al:  Metastatic infiltration of the thyroid gland causing hypothyroidism . Mt Sinai J Med NY 32:242-245, 1968;.
Shimaoka K, Van Herle AJ, Dindogru A:  Thyrotoxicosis secondary to involvement of the thyroid with malignant lymphoma . J Clin Endocrinol Metab 43:64-68, 1976;.
Mori T:  Uber das auftreten thyreotoxischer symptome bei geschwulstmetastataen in der schildruse . Frankfurt Z Pathol 12:2-24, 1913;.
Romieu C, Pages A, Gary-Bobo J:  A propos de trois cas de cancer secondaire de la thyroide . Bull Cancer 44:269-277, 1957;.
Kaplan WD, Holman L, Selenkow HA, et al:  67Ga-citrate and the nonfunctioning thyroid nodule . J Nucl Med 15:424-427, 1974;.
Heidendal GAK, Roos P, Thijs LG, et al:  Evaluation of cold areas on the thyroid scan with 67Ga-citrate . J Nucl Med 16:793-794, 1975;.
Williams DE, Chopra IJ, Orgiazzi J, et al:  Acute effects of corticosteroids on thyroid activity in Grave's disease . J Clin Endocrinol Metab 41:354-360, 1975;.

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Willis RA: The Spread of Tumors in the Human Body , ed 2. London, Butterworth and Co Ltd, 1952;, pp 271-275.
Shimaoka K, Sokal JE, Pickren JW:  Metastatic neoplasms of the thyroid gland: Pathological and clinical findings . Cancer 15:557-565, 1962;.
Gowing NFC:  The pathology and natural history of thyroid tumors . Neoplastic Diseases at Various Sites 6:103-129, 1970;.
Silverberg SG, Vidone RA:  Metastatic tumors in the thyroid . Pacific Med Surg 74:175-180, 1966;.
Guerrier Y, Nghiem TN:  Metastases thyroidiennes des tumeurs cellules claires du rein . J Franc Otorhinolaryngol 14:5-20, 1965;.
Sirota DK, Goldfield EB, Eng YF, et al:  Metastatic infiltration of the thyroid gland causing hypothyroidism . Mt Sinai J Med NY 32:242-245, 1968;.
Shimaoka K, Van Herle AJ, Dindogru A:  Thyrotoxicosis secondary to involvement of the thyroid with malignant lymphoma . J Clin Endocrinol Metab 43:64-68, 1976;.
Mori T:  Uber das auftreten thyreotoxischer symptome bei geschwulstmetastataen in der schildruse . Frankfurt Z Pathol 12:2-24, 1913;.
Romieu C, Pages A, Gary-Bobo J:  A propos de trois cas de cancer secondaire de la thyroide . Bull Cancer 44:269-277, 1957;.
Kaplan WD, Holman L, Selenkow HA, et al:  67Ga-citrate and the nonfunctioning thyroid nodule . J Nucl Med 15:424-427, 1974;.
Heidendal GAK, Roos P, Thijs LG, et al:  Evaluation of cold areas on the thyroid scan with 67Ga-citrate . J Nucl Med 16:793-794, 1975;.
Williams DE, Chopra IJ, Orgiazzi J, et al:  Acute effects of corticosteroids on thyroid activity in Grave's disease . J Clin Endocrinol Metab 41:354-360, 1975;.
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