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Therapeutic Effect of Vitamin C: Title and subTitle BreakA Co-Twin Control Study FREE

Judy Z. Miller; Walter E. Nance, MD, PhD; James A. Norton, PhD; Robert L. Wolen, PhD; Richard S. Griffith, MD; Richard J. Rose, PhD
[+] Author Affiliations

Reprint requests to 1100 W Michigan St, Indianapolis, IN 46202 (Ms Miller).


JAMA. 1977;237(3):248-251. doi:10.1001/jama.1977.03270300052006
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Three different dosages of vitamin C, dependent on body weight, were administered to 44 school-aged monozygotic twins for five months using a double-blind, co-twin control study design. The mothers recorded daily observations of cold symptoms, and multiple biochemical, anthropometric, and psychological measurements were made at the beginning and end of the study. Paired comparisons showed no significant overall treatment effect on cold symptoms, but the response was not uniform in all subgroups. Treated girls in the youngest two groups had significantly shorter and less severe illness episodes, and an effect on severity was also observed in the youngest group of boys. The seven treated twins in the latter group also grew an average of 1.3 cm more than their untreated co-twins during the five-month period of the study.

(JAMA 237:248-251, 1977)

REFERENCES

Pauling LC: Vitamin C and the Common Cold . San Francisco, WH Freeman & Co Publishers, 1970;.
Anderson TW, Reid BW, Beaton GH:  Vitamin C and the common cold: A double blind trial . Can Med Assoc J 107:503-508, 1971;.
Anderson TW, Suranyi G, Beaton GH:  The effect on winter illness of large doses of vitamin C . Can Med Assoc J 111:31-36, 1974;.
Wilson CMW, Loh HS, Foster FG:  The beneficial effect of vitamin C on the common cold . Eur J Clin Pharmacol 6:26-32, 1973;.
Coulehan J, Reisinger KS, Rogers KD, et al:  Vitamin C prophylaxis in a boarding school . N Engl J Med 290:6-10, 1974;.
Coulehan JL, Eberhard S, Kapner L, et al:  Vitamin C and acute illness in Navajo school children . N Engl J Med 295:973-977, 1976;.
Karlowski TR, Chalmers TC, Frenkel LD, et al:  Ascorbic acid for the common cold: A prophylactic and therapeutic trial . JAMA 231:1038-1042, 1975;.
Aeschbaeher HU, Brown RG:  Automated vitamin C analysis . Clin Chem 18:965-967, 1972;.
Moran LJ, Meffera RB:  Repetitive psychometric measures . Psychol Rep 5:269-275, 1959;.
Wechsler Intelligence Scale for Children— Revised . New York, The Psychological Corporation, 1974;.
Tables of the Cumulative Binomial Distribution . Cambridge, Mass, Harvard University Press, 1955;.
Sokal RR, Rohlf FJ: Biometry . San Francisco, WH Freeman & Co Publishers, 1969;, pp 289 and 211.
Lewin S:  Evaluation of potential effects of high intake of ascorbic acid . Comp Biochem Physiol 47:681-695, 1973;.
Pauling L:  Are recommended daily allowances for vitamin C adequate? Proc Nati Acad Sci 71:4442-4446, 1974;.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

Pauling LC: Vitamin C and the Common Cold . San Francisco, WH Freeman & Co Publishers, 1970;.
Anderson TW, Reid BW, Beaton GH:  Vitamin C and the common cold: A double blind trial . Can Med Assoc J 107:503-508, 1971;.
Anderson TW, Suranyi G, Beaton GH:  The effect on winter illness of large doses of vitamin C . Can Med Assoc J 111:31-36, 1974;.
Wilson CMW, Loh HS, Foster FG:  The beneficial effect of vitamin C on the common cold . Eur J Clin Pharmacol 6:26-32, 1973;.
Coulehan J, Reisinger KS, Rogers KD, et al:  Vitamin C prophylaxis in a boarding school . N Engl J Med 290:6-10, 1974;.
Coulehan JL, Eberhard S, Kapner L, et al:  Vitamin C and acute illness in Navajo school children . N Engl J Med 295:973-977, 1976;.
Karlowski TR, Chalmers TC, Frenkel LD, et al:  Ascorbic acid for the common cold: A prophylactic and therapeutic trial . JAMA 231:1038-1042, 1975;.
Aeschbaeher HU, Brown RG:  Automated vitamin C analysis . Clin Chem 18:965-967, 1972;.
Moran LJ, Meffera RB:  Repetitive psychometric measures . Psychol Rep 5:269-275, 1959;.
Wechsler Intelligence Scale for Children— Revised . New York, The Psychological Corporation, 1974;.
Tables of the Cumulative Binomial Distribution . Cambridge, Mass, Harvard University Press, 1955;.
Sokal RR, Rohlf FJ: Biometry . San Francisco, WH Freeman & Co Publishers, 1969;, pp 289 and 211.
Lewin S:  Evaluation of potential effects of high intake of ascorbic acid . Comp Biochem Physiol 47:681-695, 1973;.
Pauling L:  Are recommended daily allowances for vitamin C adequate? Proc Nati Acad Sci 71:4442-4446, 1974;.
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