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Spectinomycin-Resistant Neisseria gonorrhoeae FREE

Clyde Thornsberry, PhD; Harold Jaffee, MD; Stuart T. Brown, MD; Teresa Edwards, RN; James W. Biddle, MS; Sumner E. Thompson, MD, MPH
[+] Author Affiliations

Reprint requests to Bacteriology Division, Bureau of Laboratories, Center for Disease Control, Atlanta, GA 30333 (Dr Thornsberry).


JAMA. 1977;237(22):2405-2406. doi:10.1001/jama.1977.03270490045024
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Neisseria gonorrhoeae resistant to high levels of spectinomycin (more than 2,048 μg/ml), were isolated from specimens obtained from a patient with urethritis. The bacterial resistance to spectinomycin is probably due to ribosomal changes that are a result of a chromosomal mutation. If spectinomycin fails to cure gonorrhea, spectinomycin resistance should be considered.

(JAMA 237:2405-2406, 1977)

REFERENCES

Gonorrhea:  CDC recommended treatment schedules, 1974. Center for Disease Control . Morbidity Mortality Weekly Rep 23:341, 1974;.
Reyn A, Schmidt H, Trier M, et al:  Spectinomycin hydrochloride (Trobicin) in the treatment of gonorrhoeae: Observation of resistant strains of Neisseria gonorrhoeae . Br J Vener Dis 49:54-59, 1973;.
Jaffe HW, Biddle JW, Thornsberry C, et al:  National gonorrhea therapy monitoring study: In vitro antibiotic susceptibility and its correlation with treatment results . N Engl J Med 294:5-9, 1976;.
Lee W, Komarmy L:  New method for detecting in vitro inactivation of penicillin by Haemophilus influenzae and Staphylococcus aureus . Antimicrob Agents Chemother 10:564-566, 1976;.
Sabath LD, Matsen JM:  Assay of antimicrobial agents , in Lenette EH, Spaulding EH, Truant JP (eds): Manual of Clinical Microbiology . Washington, DC, American Society for Microbiology, 1974;, pp 428-430.
Davies J, Anderson P, Davis BD:  Inhibition of protein synthesis by spectinomycin . Science 149:1096-1098, 1965;.
Benveniste R, Yamade T, Davies J:  Enzymatic adenylylation of streptomycin and spectinomycin by R-factor-resistant Escherichia coli . Infect Immun 1:109-119, 1970;.
Maness MJ, Foster GC, Sparling PF:  Ribosomal resistance to streptomycin and spectinomycin in Neisseria gonorrhoeae . J Bacteriol 120:1293-1299, 1974;.
 Penicillinase-producing Neisseria gonorrhoeae. Center for Disease Control . Morbidity Mortality Weekly Rep 25:261, 1976;.

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Gonorrhea:  CDC recommended treatment schedules, 1974. Center for Disease Control . Morbidity Mortality Weekly Rep 23:341, 1974;.
Reyn A, Schmidt H, Trier M, et al:  Spectinomycin hydrochloride (Trobicin) in the treatment of gonorrhoeae: Observation of resistant strains of Neisseria gonorrhoeae . Br J Vener Dis 49:54-59, 1973;.
Jaffe HW, Biddle JW, Thornsberry C, et al:  National gonorrhea therapy monitoring study: In vitro antibiotic susceptibility and its correlation with treatment results . N Engl J Med 294:5-9, 1976;.
Lee W, Komarmy L:  New method for detecting in vitro inactivation of penicillin by Haemophilus influenzae and Staphylococcus aureus . Antimicrob Agents Chemother 10:564-566, 1976;.
Sabath LD, Matsen JM:  Assay of antimicrobial agents , in Lenette EH, Spaulding EH, Truant JP (eds): Manual of Clinical Microbiology . Washington, DC, American Society for Microbiology, 1974;, pp 428-430.
Davies J, Anderson P, Davis BD:  Inhibition of protein synthesis by spectinomycin . Science 149:1096-1098, 1965;.
Benveniste R, Yamade T, Davies J:  Enzymatic adenylylation of streptomycin and spectinomycin by R-factor-resistant Escherichia coli . Infect Immun 1:109-119, 1970;.
Maness MJ, Foster GC, Sparling PF:  Ribosomal resistance to streptomycin and spectinomycin in Neisseria gonorrhoeae . J Bacteriol 120:1293-1299, 1974;.
 Penicillinase-producing Neisseria gonorrhoeae. Center for Disease Control . Morbidity Mortality Weekly Rep 25:261, 1976;.
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