Clinically Suspected Deep Venous Thrombosis of the Lower Extremities: Title and subTitle BreakA Comparison of Venography, Impedance Plethysmography, and Radiolabeled Fibrinogen FREE

Kenneth M. Moser, MD; B. Bowman Brach, MD; Gerald F. Dolan, MD

[+] Author Affiliations

Reprint requests to Pulmonary Division, University of California at San Diego Medical Center, 225 W Dickinson St, San Diego, CA 92103 (Dr Moser).

JAMA. 1977;237(20):2195-2198. doi:10.1001/jama.1977.03270470031018

Text Size: A A A

Published online

Article

References

ABSTRACT

ABSTRACT | REFERENCES

To define the utility of new diagnostic approaches in patients with clinically suspected deep venous thrombosis of the lower extremities, 42 legs of 33 patients were studied by fibrinogen labeled with radioactive iodine (¹²⁵I) impedance plethysmography (IPG), and contrast venography. The clinical diagnosis was confirmed in approximately two thirds of the legs and patients.

In venogram-positive legs, fibrinogen¹²⁵I was positive in 70%, IPG in 61%, and one of the two in 78%. In venogram-negative legs, fibrinogen¹²⁵I was positive in four (21%) and IPG was negative in all. It was found that the size, age, and location of the thrombus, collateral vein development, heparin sodium therapy, and technical-interpretive choices can influence both IPG and fibrinogen¹²⁵I results. The data demonstrate that the fibrinogen¹²⁵I and IPG procedures can assist physicians in the diagnosis of clinically suspected deep venous thrombosis of the lower extremities.

(JAMA 237:2195-2198, 1977)

REFERENCES

ABSTRACT | REFERENCES

Rabinov K, Paulin S: Roentgen diagnosis of venous thrombosis in the leg . Arch Surg 104:134-144, 1972;.

Thomas ML: Phlebography . Arch Surg 104:145-151, 1972;.

Kakkar VV: The 125I-labelled fibrinogen test and phlebography in the diagnosis of deep vein thrombosis . Milbank Mem Fund Q 50:206, 1972;.

Kakkar VV, Renney JTG, Nicolaides AW, et al: 125I-fibrinogen test adapted for routine screening for deep vein thrombosis . Lancet 1:540-542, 1970;.

O'Brien JR: Detection of thrombosis with 125Iodine-fibrinogen . Lancet 2:396-398, 1970;.

Wheeler HB, Pearson D, O'Connell D, et al: Impedance phlebography: Technique, interpretation and results . Arch Surg 104:164-169, 1972;.

Gazzaniga AB, Will DI, Shobe JB, et al: 125I-fibrinogen uptake and bilateral impedance rheography . Arch Surg 108:66-68, 1974;.

Wheeler HB, O'Donnell JA, Anderson FA, et al: Occlusive impedance phlebography: A diagnostic procedure for venous thrombosis and pulmonary embolism . Prog Cardiovasc Dis 17:199-205, 1974;.

Hull R, van Aken WG, Hirsh J, et al: Impedance plethysmography using the occlusive cuff technique in the diagnosis of venous thrombosis . Circulation 53:696-700, 1976;.

Negus D, Pinto DJ, Le Quesne LP, et al: 125I-labelled fibrinogen in the diagnosis of deep vein thrombosis and its correlation with phlebography . Br J Surg 55:835-839, 1968;.

Hume M, Kuriakose TX, Zuel C, et al: 125I-fibrinogen and the prevention of venous thrombosis . Arch Surg 107:803-806, 1973;.

Kakkar VV, Corrigarn TP: Detection of deep vein thrombosis: survey and current status . Prog Cardiovasc Dis 17:207-217, 1974;.

Johnston KW, Kakkar VV, Spindler JJ, et al: A simple method for detecting deep vein thrombosis: An improved electrical impedance technique . Am J Surg 137:349-352, 1974;.

Kravis TC, Shibel EM, Brooks JD, et al: Incorporation of radiolabelled fibrinogen into venous thrombi induced in dogs . Circulation 49:158-164, 1974;.

Mavor GC, Walker MG, Dhall DP, et al: Peripheral venous scanning with 125I-tagged fibrinogen . Lancet 1:661-663, 1972;.

O'Brien JR: Peripheral venous scanning with 125I-tagged fibrinogen . Lancet 1:909-910, 1972;.

Kakkar VV: Peripheral venous scanning with 125I-tagged fibrinogen . Lancet 1:910, 1972;.

Mavor GE, Galloway JMD: The iliofemoral segment as a source of pulmonary emboli . Lancet 1:871-874, 1967;.

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal