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August 30, 1976, Vol 236, No. 9 >
ARTICLE | August 30, 1976

Benign Desoxycorticosterone-Producing Adrenal Tumor FREE

Kazuoki Kondo, MD; Takao Saruta, MD; Ikuo Saito, MD; Ryoji Yoshida, MD; Hiroshi Maruyama, MD; Shun Matsuki, MD
[+] Author Affiliations

Reprint requests to Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, Japan (Dr Saruta).


JAMA. 1976;236(9):1042-1044. doi:10.1001/jama.1976.03270100042026
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References

A woman with a benign tumor of the left adrenal cortex had a six-year history of hypertension. Serum potassium level and plasma renin activity were low. Plasma aldosterone and cortisol levels were low normal, and plasma desoxycorticosterone (DOC) level was extremely high. Iodine 131-labeled cholesterol accumulated in the tumor in the left upper quadrant of the abdomen.

At laparotomy, a benign adrenal tumor was excised; thereafter, the blood pressure and plasma DOC levels returned to normal.

We believe that this is the first case of a benign DOC-producing adrenal tumor.

(JAMA 236:1042-1044, 1976)

REFERENCES

1 +
Conn JW:  Primary aldosteronism: A new clinical syndrome . J Lab Clin Med 45:3-17, 1955;.
2 +
Skinner SL:  Improved assay methods for renin concentration and activity in human plasma . Circ Res 20:391-402, 1967;.
3 +
Bayard F, Beitins IZ, Kowarski A, et al:  Measurement of aldosterone secretion rate by radioimmunoassay . J Clin Endocrinol Metab 31:507-510, 1970;.
4 +
Fukuchi S, Nakjima K, Takenouchi T, et al:  Measurement of plasma 11-deoxycorticosterone levels by radioimmunoassay in man . Folia Endocrinol Jap 50:1392-1397, 1974;.
5 +
Murphy BP, Engelberg W, Pattee CJ:  Simple method for the determination of plasma corticoids . J Clin Endocrinol Metab 23:293-300, 1963;.
6 +
Mayes D, Nugent CA:  Determination of plasma testosterone by the use of competitive protein binding . J Clin Endocrinol Metab 28:1169-1176, 1968;.
7 +
Lindner HR, Perel E, Friedlander A, et al:  Specificity of antibodies to ovarian hormones in relation to the steroid hapten to the peptide carrier . Steroids 19:357-375, 1972;.
8 +
Brown JB:  Urinary excretion of estrogens during the menstrual cycle . Lancet 1:320-323, 1955;.
9 +
Klopper A, Michie EA, Brown JB:  A method for the determination of urinary pregnanediol . J Endocrinol 12:209-219, 1955;.
10 +
Kaplan NM:  Adrenal causes of hypertension . Arch Intern Med 133:1001-1006, 1974;.
11 +
Biglieri EG, Herron MA, Brust N:  17-hydroxylation deficiency in man . J Clin Invest 45:1946-1954, 1966;.
12 +
Eberlein WR, Bongiovanni AM:  Plasma and urinary corticosteroids in the hypertensive form of congenital adrenal hyperplasia . J Biol Chem 223:85-94, 1956;.
13 +
Tan SY, Mulrow PJ:  The contribution of the zona fasciculata and glomerulosa to plasma 11-deoxycorticosteroid levels in man . J Clin Endocrinol Metab 41:126-130, 1975;.
14 +
Solomon SS, Swesie SP, Paulsen A:  Feminizing adrenocortical carcinoma with hypertension . J Clin Endocrinol Metab 28:608-612, 1968;.
15 +
West CB, Kumagai F, Simons EL, et al:  Adrenocortical carcinoma with feminization and hypertension associated with a defect in 11 beta hydroxylation . J Clin Endocrinol Metab 24:567-579, 1964;.
16 +
Biglieri EG, Shambelan M, Slaton P:  Effect of adrenocorticotropin on desoxycorticosterone, corticosterone and aldosterone excretion . J Clin Endocrinol Metab 29:1090-1101, 1969;.

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1 +
Conn JW:  Primary aldosteronism: A new clinical syndrome . J Lab Clin Med 45:3-17, 1955;.
2 +
Skinner SL:  Improved assay methods for renin concentration and activity in human plasma . Circ Res 20:391-402, 1967;.
3 +
Bayard F, Beitins IZ, Kowarski A, et al:  Measurement of aldosterone secretion rate by radioimmunoassay . J Clin Endocrinol Metab 31:507-510, 1970;.
4 +
Fukuchi S, Nakjima K, Takenouchi T, et al:  Measurement of plasma 11-deoxycorticosterone levels by radioimmunoassay in man . Folia Endocrinol Jap 50:1392-1397, 1974;.
5 +
Murphy BP, Engelberg W, Pattee CJ:  Simple method for the determination of plasma corticoids . J Clin Endocrinol Metab 23:293-300, 1963;.
6 +
Mayes D, Nugent CA:  Determination of plasma testosterone by the use of competitive protein binding . J Clin Endocrinol Metab 28:1169-1176, 1968;.
7 +
Lindner HR, Perel E, Friedlander A, et al:  Specificity of antibodies to ovarian hormones in relation to the steroid hapten to the peptide carrier . Steroids 19:357-375, 1972;.
8 +
Brown JB:  Urinary excretion of estrogens during the menstrual cycle . Lancet 1:320-323, 1955;.
9 +
Klopper A, Michie EA, Brown JB:  A method for the determination of urinary pregnanediol . J Endocrinol 12:209-219, 1955;.
10 +
Kaplan NM:  Adrenal causes of hypertension . Arch Intern Med 133:1001-1006, 1974;.
11 +
Biglieri EG, Herron MA, Brust N:  17-hydroxylation deficiency in man . J Clin Invest 45:1946-1954, 1966;.
12 +
Eberlein WR, Bongiovanni AM:  Plasma and urinary corticosteroids in the hypertensive form of congenital adrenal hyperplasia . J Biol Chem 223:85-94, 1956;.
13 +
Tan SY, Mulrow PJ:  The contribution of the zona fasciculata and glomerulosa to plasma 11-deoxycorticosteroid levels in man . J Clin Endocrinol Metab 41:126-130, 1975;.
14 +
Solomon SS, Swesie SP, Paulsen A:  Feminizing adrenocortical carcinoma with hypertension . J Clin Endocrinol Metab 28:608-612, 1968;.
15 +
West CB, Kumagai F, Simons EL, et al:  Adrenocortical carcinoma with feminization and hypertension associated with a defect in 11 beta hydroxylation . J Clin Endocrinol Metab 24:567-579, 1964;.
16 +
Biglieri EG, Shambelan M, Slaton P:  Effect of adrenocorticotropin on desoxycorticosterone, corticosterone and aldosterone excretion . J Clin Endocrinol Metab 29:1090-1101, 1969;.

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