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July 19, 1976, Vol 236, No. 3 >
ARTICLE | July 19, 1976

Bacteremic Infections Due to Clindamycin-Resistant Streptococci FREE

Mark S. Drapkin, MD; Adolf W. Karchmer, MD; Robert C. Moellering, Jr, MD
[+] Author Affiliations

Reprint requests to Massachusetts General Hospital, Boston, MA 02114 (Dr Karchmer).


JAMA. 1976;236(3):263-265. doi:10.1001/jama.1976.03270030017019
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References

We have recently observed four patients with bacteremic infections due to group A streptococci that were highly resistant to clindamycin and only moderately susceptible to erythromycin. Two of the infections developed while the patients were receiving clindamycin. The organisms were not β-hemolytic under standard conditions nor were they M or T typable. We urge that all streptococci isolated from patients with serious infections be grouped serologically and be tested for antibiotic susceptibilities, especially if therapy with antibiotics other than penicillin is to be considered.

(JAMA 236:263-265, 1976)

REFERENCES

1 +
McGehee RF Jr, Smith CB, Wilcox C, et al:  Comparative studies of antibacterial activity in vitro and absorption and excretion of lincomycin and clindamycin . Am J Med Sci 256:279-292, 1968;.
2 +
Karchmer AW, Moellering RC Jr, Watson BK:  Susceptibility of various serogroups of streptococci to clindamycin and lincomycin . Antimicrob Agents Chemother 7:164-167, 1975;.
3 +
Jackson H:  Prevention of rheumatic fever . Clin Pediatr 12:501-503, 1973;.
4 +
Breese BB, Disney FA, Talpey W, et al:  Streptococcal infections in children . Am J Dis Child 128:457-460, 1974;.
5 +
Carr WGL:  Clindamycin palmitate hydrochloride: A clinical trial in a pediatric office practice . Curr Ther Res 15:630-641, 1973;.
6 +
Stillerman M, Isenberg HD, Facklam RR:  Streptococcal pharyngitis therapy: Comparison of clindamycin palmitate and potassium phenoxymethyl penicillin . Antimicrob Agents Chemother 4:514-520, 1973;.
7 +
Sinanian R, Ruoff G, Panzer J, et al:  Streptococcal pharyngitis: A comparison of the eradication of the organisms by five- and tenday antibiotic therapy . Curr Ther Res 14:716-720, 1972;.
8 +
Kohn J, Hewitt JH, Frazer CAM:  Group A streptococci resistant to lincomycin . Br Med J 1:703, 1968;.
9 +
Lowbury EJL, Hurst L:  The sensitivity of staphylococci and other wound bacteria to erythromycin, oleandomycin, and spiramycin . J Clin Pathol 12:163-169, 1959;.
10 +
Lowbury EJL, Kidson A:  Group A streptococci resistant to lincomycin . Br Med J 2:490-491, 1968;.
11 +
Sanders E, Foster MT, Scott D:  Group A beta-hemolytic streptococci resistant to erythromycin and lincomycin . N Engl J Med 278:538-540, 1968;.
12 +
Dixon JMS, Lipinski AE:  Resistance of group A beta-hemolytic streptococci to lincomycin and erythromycin . Antimicrob Agents Chemother 1:333-339, 1972;.
13 +
Dixon JMS, Lipinski AE:  Infections with β-hemolytic streptococcus resistant to lincomycin and erythromycin and observations on zonalpattern resistance to lincomycin . J Infect Dis 130:351-356, 1974;.
14 +
Lancefield RC:  A microprecipitin-technique for classifying hemolytic streptococci and improved methods for producing antisera . Proc Soc Exp Biol Med 38:473-478, 1938;.
15 +
Rantz LA, Randall E:  Use of autoclaved extracts of hemolytic streptococci for serological grouping . Stanford Med Bull 13:290-291, 1955;.
16 +
Watson BK, Moellering RC Jr, Kunz LJ:  Identification of streptococci: Use of lysozyme and Streptomyces albus filtrate in the preparation of extracts for Lancefield grouping . J Clin Microbiol 1:274-278, 1975;.
17 +
Bauer WW, Kirby WWM, Sherris JC, et al:  Antibiotic susceptibility testing by a standard single disc method . J Clin Pathol 45:493-496; 1966;.
18 +
Mitsuhashi S, Inoue M, Fuse A, et al:  Drug resistance in Streptococcus pyogenes . Jap J Microbiol 18:98-99, 1974;.
19 +
Konno M, Ubukata K, Fujii R:  Macrolideresistant strains of group A beta hemolytic streptococci isolated from pediatric patients . Read before the 14th Interscience Conference on Antimicrobial Agents and Chemotherapy, Sept 11-13, 1974 .
20 +
Fujii R, Konno M, Ubukata K, et al:  Fundamental and clinical studies on clindamycin-2palmitate in pediatrics . Jap J Antibiot 26:545-561, 1973;.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

1 +
McGehee RF Jr, Smith CB, Wilcox C, et al:  Comparative studies of antibacterial activity in vitro and absorption and excretion of lincomycin and clindamycin . Am J Med Sci 256:279-292, 1968;.
2 +
Karchmer AW, Moellering RC Jr, Watson BK:  Susceptibility of various serogroups of streptococci to clindamycin and lincomycin . Antimicrob Agents Chemother 7:164-167, 1975;.
3 +
Jackson H:  Prevention of rheumatic fever . Clin Pediatr 12:501-503, 1973;.
4 +
Breese BB, Disney FA, Talpey W, et al:  Streptococcal infections in children . Am J Dis Child 128:457-460, 1974;.
5 +
Carr WGL:  Clindamycin palmitate hydrochloride: A clinical trial in a pediatric office practice . Curr Ther Res 15:630-641, 1973;.
6 +
Stillerman M, Isenberg HD, Facklam RR:  Streptococcal pharyngitis therapy: Comparison of clindamycin palmitate and potassium phenoxymethyl penicillin . Antimicrob Agents Chemother 4:514-520, 1973;.
7 +
Sinanian R, Ruoff G, Panzer J, et al:  Streptococcal pharyngitis: A comparison of the eradication of the organisms by five- and tenday antibiotic therapy . Curr Ther Res 14:716-720, 1972;.
8 +
Kohn J, Hewitt JH, Frazer CAM:  Group A streptococci resistant to lincomycin . Br Med J 1:703, 1968;.
9 +
Lowbury EJL, Hurst L:  The sensitivity of staphylococci and other wound bacteria to erythromycin, oleandomycin, and spiramycin . J Clin Pathol 12:163-169, 1959;.
10 +
Lowbury EJL, Kidson A:  Group A streptococci resistant to lincomycin . Br Med J 2:490-491, 1968;.
11 +
Sanders E, Foster MT, Scott D:  Group A beta-hemolytic streptococci resistant to erythromycin and lincomycin . N Engl J Med 278:538-540, 1968;.
12 +
Dixon JMS, Lipinski AE:  Resistance of group A beta-hemolytic streptococci to lincomycin and erythromycin . Antimicrob Agents Chemother 1:333-339, 1972;.
13 +
Dixon JMS, Lipinski AE:  Infections with β-hemolytic streptococcus resistant to lincomycin and erythromycin and observations on zonalpattern resistance to lincomycin . J Infect Dis 130:351-356, 1974;.
14 +
Lancefield RC:  A microprecipitin-technique for classifying hemolytic streptococci and improved methods for producing antisera . Proc Soc Exp Biol Med 38:473-478, 1938;.
15 +
Rantz LA, Randall E:  Use of autoclaved extracts of hemolytic streptococci for serological grouping . Stanford Med Bull 13:290-291, 1955;.
16 +
Watson BK, Moellering RC Jr, Kunz LJ:  Identification of streptococci: Use of lysozyme and Streptomyces albus filtrate in the preparation of extracts for Lancefield grouping . J Clin Microbiol 1:274-278, 1975;.
17 +
Bauer WW, Kirby WWM, Sherris JC, et al:  Antibiotic susceptibility testing by a standard single disc method . J Clin Pathol 45:493-496; 1966;.
18 +
Mitsuhashi S, Inoue M, Fuse A, et al:  Drug resistance in Streptococcus pyogenes . Jap J Microbiol 18:98-99, 1974;.
19 +
Konno M, Ubukata K, Fujii R:  Macrolideresistant strains of group A beta hemolytic streptococci isolated from pediatric patients . Read before the 14th Interscience Conference on Antimicrobial Agents and Chemotherapy, Sept 11-13, 1974 .
20 +
Fujii R, Konno M, Ubukata K, et al:  Fundamental and clinical studies on clindamycin-2palmitate in pediatrics . Jap J Antibiot 26:545-561, 1973;.

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