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November 29, 1976, Vol 236, No. 22 >
ARTICLE | November 29, 1976

Clindamycin and Diarrhea FREE

Gary D. Friedman, MD; Marie J. Gérard, MD; Hans K. Ury, PhD
[+] Author Affiliations

Reprint requests to Department of Medical Methods Research, The Permanente Medical Group, 3779 Piedmont Ave, Oakland, CA 94611 (Dr Friedman).


JAMA. 1976;236(22):2498-2500. doi:10.1001/jama.1976.03270230020020
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References

Of 298 outpatients receiving clindamycin for a variety of indications, diarrhea developed in ten (3.4%); none were diagnosed as having pseudomembranous colitis. This is well within the range of relative frequencies of diarrhea development (0% to 22.2%) reported in 45 previous studies. Reliance solely on computer-recorded instances of diarrhea yielded a substantial underestimate of diarrhea occurrence, but the rate was still significantly higher (P <.05) in clindamycin users than in nonusers.

(JAMA 236:2498-2500, 1976)

REFERENCES

1 +
Breese BB, Disney FA, Talpey W, et al:  Streptococcal infections in children: Comparison of the therapeutic effectiveness of erythromycin, penicillin, clindamycin . Am J Dis Child 128:457-460, 1974;.
2 +
De Haan RM, Schellenberg D, Van den Bosch WD, et al:  Clindamycin palmitate in healthy men: General tolerance and effect on stools . Curr Ther Res 14:81-90, 1972;.
3 +
Feigin RD, Keeney RE, Nusrala J, et al:  Efficacy of clindamycin therapy for otitis media . Arch Otolaryngol 98:27-31, 1973;.
4 +
Geddes AM:  Lincomycin and clindamycin colitis . Br Med J 4:591, 1974;.
5 +
Hubbard WN:  Clindamycin and pseudomembranous colitis . Lancet 1:172, 1974;.
6 +
Jackson H:  Prevention of rheumatic fever: A comparative study of clindamycin palmitate and ampicillin in the treatment of group A β-hemolytic streptococcal pharyngitis . Clin Pediatr 12:501-503, 1973;.
7 +
Marshall BY, Georgson HM, Lee IK, et al:  Experience with clindamycin in common infections seen in general practice . Br J Clin Prac 25:503-505, 1971;.
8 +
Shinian R, Ruoff G, Panzer J, et al:  Streptococcal pharyngitis: A comparison of the eradication of the organism by 5- and 10-day antibiotic therapy . Curr Ther Res 14:716-720, 1972;.
9 +
Tedesco FJ, Barton RW, Alpers DH:  Clindamycin-associated colitis: A prospective study . Ann Intern Med 81:429-433, 1974;.
10 +
Wilson DH:  Lincomycin and clindamycin colitis . Br Med J 4:288-289, 1974;.
11 +
Friedman GD, Collen MF, Harris LE, et al:  Experience in monitoring drug reactions in outpatients . JAMA 217:567-572, 1971;.
12 +
Friedman GD, Collen MF:  A method for monitoring adverse drug reactions , in LeCam L, Neyman J, Scott E (eds): Proceedings of the Sixth Berkeley Symposium on Mathematical Statistics and Probability , vol 6. University of California Press, 1970;, pp 367-382.
13 +
Friedman GD:  Screening criteria for drug monitoring . J Chronic Dis 25:11-20, 1972;.
14 +
Anderson TW, Burstein H:  Approximating the upper binomial confidence limit . J Am Statistical Assoc 62:857-861, 1967;.
15 +
Anderson TW, Burstein H:  Approximating the lower binomial confidence limit . J Am Statistical Assoc 63:1413-1415, 1968;.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

1 +
Breese BB, Disney FA, Talpey W, et al:  Streptococcal infections in children: Comparison of the therapeutic effectiveness of erythromycin, penicillin, clindamycin . Am J Dis Child 128:457-460, 1974;.
2 +
De Haan RM, Schellenberg D, Van den Bosch WD, et al:  Clindamycin palmitate in healthy men: General tolerance and effect on stools . Curr Ther Res 14:81-90, 1972;.
3 +
Feigin RD, Keeney RE, Nusrala J, et al:  Efficacy of clindamycin therapy for otitis media . Arch Otolaryngol 98:27-31, 1973;.
4 +
Geddes AM:  Lincomycin and clindamycin colitis . Br Med J 4:591, 1974;.
5 +
Hubbard WN:  Clindamycin and pseudomembranous colitis . Lancet 1:172, 1974;.
6 +
Jackson H:  Prevention of rheumatic fever: A comparative study of clindamycin palmitate and ampicillin in the treatment of group A β-hemolytic streptococcal pharyngitis . Clin Pediatr 12:501-503, 1973;.
7 +
Marshall BY, Georgson HM, Lee IK, et al:  Experience with clindamycin in common infections seen in general practice . Br J Clin Prac 25:503-505, 1971;.
8 +
Shinian R, Ruoff G, Panzer J, et al:  Streptococcal pharyngitis: A comparison of the eradication of the organism by 5- and 10-day antibiotic therapy . Curr Ther Res 14:716-720, 1972;.
9 +
Tedesco FJ, Barton RW, Alpers DH:  Clindamycin-associated colitis: A prospective study . Ann Intern Med 81:429-433, 1974;.
10 +
Wilson DH:  Lincomycin and clindamycin colitis . Br Med J 4:288-289, 1974;.
11 +
Friedman GD, Collen MF, Harris LE, et al:  Experience in monitoring drug reactions in outpatients . JAMA 217:567-572, 1971;.
12 +
Friedman GD, Collen MF:  A method for monitoring adverse drug reactions , in LeCam L, Neyman J, Scott E (eds): Proceedings of the Sixth Berkeley Symposium on Mathematical Statistics and Probability , vol 6. University of California Press, 1970;, pp 367-382.
13 +
Friedman GD:  Screening criteria for drug monitoring . J Chronic Dis 25:11-20, 1972;.
14 +
Anderson TW, Burstein H:  Approximating the upper binomial confidence limit . J Am Statistical Assoc 62:857-861, 1967;.
15 +
Anderson TW, Burstein H:  Approximating the lower binomial confidence limit . J Am Statistical Assoc 63:1413-1415, 1968;.

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