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Novmber 8, 1976, Vol 236, No. 19 >
ARTICLE | Novmber 8, 1976

Mucoid Pseudomonas aeruginosa: Title and subTitle BreakA Sign of Cystic Fibrosis in Young Adults With Chronic Pulmonary Disease? FREE

Herbert Y. Reynolds, MD; Paul A. Di Sant'Agnese, MD; Charles H. Zierdt, PhD
[+] Author Affiliations

Reprint requests to R 11B18, Bldg 10, National Institutes of Health, Bethesda, MD 20014 (Dr Reynolds).


JAMA. 1976;236(19):2190-2192. doi:10.1001/jama.1976.03270200028024
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References

Two adult patients with cystic fibrosis had late onset of symptoms with principal involvement only of the lungs. The absence of other typical features of cystic fibrosis confused the diagnosis. Recovery of mucoid Pseudomonas aeruginosa from sputum cultures helped to establish the diagnosis in these patients, because these mucoid isolates are rarely obtained from subjects who do not have cystic fibrosis. Recent findings, which have identified the mucoid isolates as predominantly a single strain of P aeruginosa and have documented its widespread carriage in the United States by patients with cystic fibrosis, point to an interesting epidemiologic relationship between this bacterium and this disease.

(JAMA 236:2190-2192, 1976)

REFERENCES

1 +
Cetin ET, Toreci K, Ang 0:  Encapsulated Pseudomonas aeruginosa (Pseudomonas aeruginosa mucosus) strains . J Bacteriol 89:1432-1433, 1965;.
2 +
Doggett RG, Harrison GM, Carter RE Jr:  Mucoid Pseudomonas aeruginosa in patients with chronic illnesses . Lancet 1:236-237, 1971;.
3 +
Shwachman H, Kulczycki LL:  Long-term study of 150 patients with cystic fibrosis . Am J Dis Child 96:6-15, 1958;.
4 +
Gibson LE, Cooke RE:  A test for concentration of electrolytes in sweat in cystic fibrosis of the pancreas utilizing pilocarpine by iontophoresis . Pediatrics 23:545-549, 1959;.
5 +
Fisher MW, Devlin HB, Gnabasik FG:  New immunotype schema for Pseudomonas aeruginosa based on protective antigens . J Bacteriol 98:835-836, 1969;.
6 +
Homma JY, Shionoya H, Yamada H, et al:  Production of antibody against Pseudomonas aeruginosa and its serological typing . Jap J Exp Med 41:89-94, 1971;.
7 +
Zierdt CH, Williams RL:  Serotyping of Pseudomonas aeruginosa isolates from patients with cystic fibrosis of the pancreas . J Clin Microbiol 1:521-526, 1975;.
8 +
Zierdt CH, Schmidt PJ:  Dissociation in Pseudomonas aeruginosa . J Bacteriol 87:1003-1010, 1964;.
9 +
Reynolds HY, Levine AS, Wood RE, et al:  Pseudomonas aeruginosa infections: Persisting problems and current research to find new therapies . Ann Intern Med 82:819-832, 1975;.
10 +
Di Sant'Agnese PA:  Cystic fibrosis (mucoviscidosis) . Am Fam Physician GP 7:102-111, 1973;.
11 +
Drozier DH:  Cystic fibrosis—A not-so-fatal disease . Pediatr Clin North Am 21:935-950, 1974;.
12 +
Elston HR, Hoffman KC:  Increasing incidence of encapsulated Pseudomonas aeruginosa strains . Am J Clin Pathol 48:519, 1967;.
13 +
Anderson CH, Freeman M:  "Sweat test" results in normal persons of different ages compared with families with fibrocystic disease of the pancreas . Arch Dis Child 35:581-587, 1960;.
14 +
Gibson LE:  The decline of the sweat test: Comments on pitfalls and reliability . Clin Pediatr 12:450-453, 1973;.
15 +
Boat TF, Hilman BC, Waring WW:  Cystic fibrosis in the teens and beyond . Patient Care , (March 15) , 1975;, pp 120-144.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

1 +
Cetin ET, Toreci K, Ang 0:  Encapsulated Pseudomonas aeruginosa (Pseudomonas aeruginosa mucosus) strains . J Bacteriol 89:1432-1433, 1965;.
2 +
Doggett RG, Harrison GM, Carter RE Jr:  Mucoid Pseudomonas aeruginosa in patients with chronic illnesses . Lancet 1:236-237, 1971;.
3 +
Shwachman H, Kulczycki LL:  Long-term study of 150 patients with cystic fibrosis . Am J Dis Child 96:6-15, 1958;.
4 +
Gibson LE, Cooke RE:  A test for concentration of electrolytes in sweat in cystic fibrosis of the pancreas utilizing pilocarpine by iontophoresis . Pediatrics 23:545-549, 1959;.
5 +
Fisher MW, Devlin HB, Gnabasik FG:  New immunotype schema for Pseudomonas aeruginosa based on protective antigens . J Bacteriol 98:835-836, 1969;.
6 +
Homma JY, Shionoya H, Yamada H, et al:  Production of antibody against Pseudomonas aeruginosa and its serological typing . Jap J Exp Med 41:89-94, 1971;.
7 +
Zierdt CH, Williams RL:  Serotyping of Pseudomonas aeruginosa isolates from patients with cystic fibrosis of the pancreas . J Clin Microbiol 1:521-526, 1975;.
8 +
Zierdt CH, Schmidt PJ:  Dissociation in Pseudomonas aeruginosa . J Bacteriol 87:1003-1010, 1964;.
9 +
Reynolds HY, Levine AS, Wood RE, et al:  Pseudomonas aeruginosa infections: Persisting problems and current research to find new therapies . Ann Intern Med 82:819-832, 1975;.
10 +
Di Sant'Agnese PA:  Cystic fibrosis (mucoviscidosis) . Am Fam Physician GP 7:102-111, 1973;.
11 +
Drozier DH:  Cystic fibrosis—A not-so-fatal disease . Pediatr Clin North Am 21:935-950, 1974;.
12 +
Elston HR, Hoffman KC:  Increasing incidence of encapsulated Pseudomonas aeruginosa strains . Am J Clin Pathol 48:519, 1967;.
13 +
Anderson CH, Freeman M:  "Sweat test" results in normal persons of different ages compared with families with fibrocystic disease of the pancreas . Arch Dis Child 35:581-587, 1960;.
14 +
Gibson LE:  The decline of the sweat test: Comments on pitfalls and reliability . Clin Pediatr 12:450-453, 1973;.
15 +
Boat TF, Hilman BC, Waring WW:  Cystic fibrosis in the teens and beyond . Patient Care , (March 15) , 1975;, pp 120-144.

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