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Novmber 8, 1976, Vol 236, No. 19 >
ARTICLE | Novmber 8, 1976

Skeletal and Soft Tissue Sarcomas: Title and subTitle BreakTreatment With Adjuvant Immunotherapy FREE

Courtney M. Townsend, Jr, MD; Frederick R. Eilber, MD; Donald L. Morton, MD
[+] Author Affiliations

Reprint requests to the Division of Oncology, UCLA School of Medicine, The Center for the Health Sciences, Los Angeles, CA 90024 (Dr Morton).


JAMA. 1976;236(19):2187-2189. doi:10.1001/jama.1976.03270200025023
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References

Because there is evidence for an active immunologic response against sarcoma, a clinical trial of adjuvant immunotherapy using bacillus Calmette-Guérin (BCG) and tumor cell vaccine was begun.

Eleven of 18 patients with localized soft tissue sarcoma who received immunotherapy are free of disease, compared to only 5 of 15 treated by operation alone who are free of disease. Furthermore, immunotherapy also prolonged the median disease-free interval from 7.3 months to 15 months in the patients who experienced recurrence of their disease.

(JAMA 236:2187-2189, 1976)

REFERENCES

1 +
Marcove RC, Mike V, Hajek JV, et al:  Osteogenic sarcoma under the age of twenty-one: A review of 145 operative cases . Am J Bone Joint Surg 52:411-423, 1970;.
2 +
Cantin J, McNeer GP, Chu F, et al:  The problem of local recurrence after treatment of soft tissue sarcoma . Ann Surg 168:47-53, 1968;.
3 +
Martin RG, Butler JJ, Albores SJ:  Soft tissue tumors: Surgical treatment and results , in Tumors of Bone and Soft Tissue . Chicago, Year Book Medical Publishers Inc, 1965;, pp 333-348.
4 +
Suit HD, Russell WO:  Radiation therapy of soft tissue sarcomas . Cancer 36:759-764, 1975;.
5 +
Morton DL, Malmgren RA:  Human osteosarcomas: Immunologic evidence suggesting an associated infectious agent . Science 162:1279-1281, 1968;.
6 +
Priori ES, Wilbur JH, Dmochowski L:  Immunofluorescence tests on sera of patients with osteosarcoma . J Nati Cancer Inst 46:1299-1308, 1971;.
7 +
Eilber FR, Morton DL:  Sarcoma-specific antigens: Detection by complement fixation with serum from sarcoma patients . J Natl Cancer Inst 44:651-656, 1970;.
8 +
Cohen AM, Ketcham AS, Morton DL:  Tumor-specific cellular cytotoxicity to human sarcomas: Evidence for a cell-mediated host immune response to a common sarcoma cell-surface antigen . J Natl Cancer Inst 50:585-589, 1973;.
9 +
Morton DL, Eilber FR, Malmgren RA:  Immunologic factors in malignant melanomas: Skeletal and soft tissue sarcomas of man . Oncology 1:242-255, 1970;.
10 +
Hellstrom I, Sjogren HO, Warner G, et al:  Blocking of cell-mediated tumor immunity by sera from patients with growing neoplasms . Int J Cancer 7:266-237, 1971;.
11 +
Bast RC, Zbar B, Borsos T, et al:  BCG and cancer . N Engl J Med 290:1412-1413, 1974;.
12 +
Gutterman JU, Mavligit G, Gottlieb J, et al:  Chemoimmunotherapy of disseminated malignant melanoma with dimethyl-triazeno imidazole carboxamide (DTIC) and BCG . N Engl J Med 291:592-596, 1974;.
13 +
Mathe G, Amiel JL, Schwarzenberg L, et al:  Active immunotherapy for acute lymphoblastic leukemia . Lancet 1:697, 1969;.
14 +
Eilber FR, Holmes EC, Morton DL:  Immunotherapy experiments with a methylcholanthrene-induced guinea pig liposarcoma . J Natl Cancer Inst 46:803-808, 1971;.
15 +
Holmes EC, Kahan BD, Morton DL:  Soluble tumor-specific transplantation antigens from methylcholanthrene-induced guinea pig sarcoma . Cancer 25:373-379, 1970;.
16 +
Morton DL, Joseph WL, Ketcham AS, et al:  Surgical resection and adjunctive immunotherapy for selected patients with multiple pulmonary metastases . Ann Surg 178:360-366, 1973;.
17 +
Jaffe N:  Recent advances in the chemotherapy of metastatic osteosarcoma . Cancer 30:1627-1638, 1972;.
18 +
Rosen G, Suwansirikul S, Kwon TC, et al:  High-dose methotrexate with Citrovorum Factor and Adriamycin in childhood osteosarcoma . Cancer 33:1151-1163, 1974;.
19 +
Cortes EP, Holland JF, Wang JJ, et al:  Amputation and Adriamycin in primary osteosarcoma . N Engl J Med 291:998-1000, 1974;.
20 +
Jaffe N, Frei E, Traggis D, et al:  Adjuvant methotrexate and Citrovorum Factor treatment of osteogenic sarcoma . N Engl J Med 291:994-997, 1974;.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

1 +
Marcove RC, Mike V, Hajek JV, et al:  Osteogenic sarcoma under the age of twenty-one: A review of 145 operative cases . Am J Bone Joint Surg 52:411-423, 1970;.
2 +
Cantin J, McNeer GP, Chu F, et al:  The problem of local recurrence after treatment of soft tissue sarcoma . Ann Surg 168:47-53, 1968;.
3 +
Martin RG, Butler JJ, Albores SJ:  Soft tissue tumors: Surgical treatment and results , in Tumors of Bone and Soft Tissue . Chicago, Year Book Medical Publishers Inc, 1965;, pp 333-348.
4 +
Suit HD, Russell WO:  Radiation therapy of soft tissue sarcomas . Cancer 36:759-764, 1975;.
5 +
Morton DL, Malmgren RA:  Human osteosarcomas: Immunologic evidence suggesting an associated infectious agent . Science 162:1279-1281, 1968;.
6 +
Priori ES, Wilbur JH, Dmochowski L:  Immunofluorescence tests on sera of patients with osteosarcoma . J Nati Cancer Inst 46:1299-1308, 1971;.
7 +
Eilber FR, Morton DL:  Sarcoma-specific antigens: Detection by complement fixation with serum from sarcoma patients . J Natl Cancer Inst 44:651-656, 1970;.
8 +
Cohen AM, Ketcham AS, Morton DL:  Tumor-specific cellular cytotoxicity to human sarcomas: Evidence for a cell-mediated host immune response to a common sarcoma cell-surface antigen . J Natl Cancer Inst 50:585-589, 1973;.
9 +
Morton DL, Eilber FR, Malmgren RA:  Immunologic factors in malignant melanomas: Skeletal and soft tissue sarcomas of man . Oncology 1:242-255, 1970;.
10 +
Hellstrom I, Sjogren HO, Warner G, et al:  Blocking of cell-mediated tumor immunity by sera from patients with growing neoplasms . Int J Cancer 7:266-237, 1971;.
11 +
Bast RC, Zbar B, Borsos T, et al:  BCG and cancer . N Engl J Med 290:1412-1413, 1974;.
12 +
Gutterman JU, Mavligit G, Gottlieb J, et al:  Chemoimmunotherapy of disseminated malignant melanoma with dimethyl-triazeno imidazole carboxamide (DTIC) and BCG . N Engl J Med 291:592-596, 1974;.
13 +
Mathe G, Amiel JL, Schwarzenberg L, et al:  Active immunotherapy for acute lymphoblastic leukemia . Lancet 1:697, 1969;.
14 +
Eilber FR, Holmes EC, Morton DL:  Immunotherapy experiments with a methylcholanthrene-induced guinea pig liposarcoma . J Natl Cancer Inst 46:803-808, 1971;.
15 +
Holmes EC, Kahan BD, Morton DL:  Soluble tumor-specific transplantation antigens from methylcholanthrene-induced guinea pig sarcoma . Cancer 25:373-379, 1970;.
16 +
Morton DL, Joseph WL, Ketcham AS, et al:  Surgical resection and adjunctive immunotherapy for selected patients with multiple pulmonary metastases . Ann Surg 178:360-366, 1973;.
17 +
Jaffe N:  Recent advances in the chemotherapy of metastatic osteosarcoma . Cancer 30:1627-1638, 1972;.
18 +
Rosen G, Suwansirikul S, Kwon TC, et al:  High-dose methotrexate with Citrovorum Factor and Adriamycin in childhood osteosarcoma . Cancer 33:1151-1163, 1974;.
19 +
Cortes EP, Holland JF, Wang JJ, et al:  Amputation and Adriamycin in primary osteosarcoma . N Engl J Med 291:998-1000, 1974;.
20 +
Jaffe N, Frei E, Traggis D, et al:  Adjuvant methotrexate and Citrovorum Factor treatment of osteogenic sarcoma . N Engl J Med 291:994-997, 1974;.

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