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ARTICLE |

Cyclamate Sweeteners FREE

Thomas H. Jukes, PhD, DSc
[+] Author Affiliations

Reprint requests to the University of California, Space Sciences Laboratory, Berkeley, CA 94720 (Dr Jukes).


JAMA. 1976;236(17):1987-1989. doi:10.1001/jama.1976.03270180059029
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ON OCT 18, 1969, the Secretary of Health, Education, and Welfare, Mr Robert Finch, announced that "the artificial sweetener cyclamate was removed from the list of substances generally recognized as safe (GRAS) for use in food." In so doing, he invoked the "so-called Delaney amendment which states that any food additive must be removed from the market if it has been shown to cause cancer when fed to humans or animals." This announcement caused surprise and consternation both in the United States and other countries, for cyclamates had been in steadily increasing use since the early 1950s, and in 1959 had been put on the safe list for addition to foods. The ban is still making news.

The discovery by Sveda in 1937 of a sweet substance lacking the aftertaste of saccharin started a train of research and development that led to the introduction of Sucaryl sodium, C6H

REFERENCES

Kojima S, Ichibagase H:  Studies on synthetic sweetening agents: 8. Cyclohexylamine, metabolite of sodium cyclamate . Chem Pharm Bull 14:971, 1966;.
Price JM, Biava CG, Oser BL, et al:  Bladder tumors in rats fed cyclohexylamine or high doses of a mixture of cyclamate and saccharin . Science 167:1131, 1970;.
 How McPherson's rule sank cyclamates , editorial. Nature 224:398, 1969;.
Bryan GT, Yoshida O:  Urinary bladder carcinogens . Arch Environ Health 23:6, 1971;.
Pines WL:  The cyclamate story . FDA Consumer 8:19-27, 1974;.
 Cancer unit submits report on cyclamate . FDA Consumer 10:24, 1976;.

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Kojima S, Ichibagase H:  Studies on synthetic sweetening agents: 8. Cyclohexylamine, metabolite of sodium cyclamate . Chem Pharm Bull 14:971, 1966;.
Price JM, Biava CG, Oser BL, et al:  Bladder tumors in rats fed cyclohexylamine or high doses of a mixture of cyclamate and saccharin . Science 167:1131, 1970;.
 How McPherson's rule sank cyclamates , editorial. Nature 224:398, 1969;.
Bryan GT, Yoshida O:  Urinary bladder carcinogens . Arch Environ Health 23:6, 1971;.
Pines WL:  The cyclamate story . FDA Consumer 8:19-27, 1974;.
 Cancer unit submits report on cyclamate . FDA Consumer 10:24, 1976;.
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