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April 5, 1976, Vol 235, No. 14 >
ARTICLE | April 5, 1976

MBK Neuropathy Among Spray Painters FREE

Joseph S. Mallov, MD
[+] Author Affiliations

Reprint requests to Department of Medicine, Montefiore-University of Pittsburgh Hospital, 3459 Fifth Ave, Pittsburgh, PA 15213 (Dr Mallov).


JAMA. 1976;235(14):1455-1457. doi:10.1001/jama.1976.03260400021020
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References

It has been suggested that the solvent methyl N-butyl ketone (MBK) may cause peripheral neuropathy in humans. An Investigation was undertaken after two cases of peripheral neuropathy among spray painters at one work site were reported to the National Institute for Occupational Safety and Health. Twenty-six painters were interviewed and examined. Two were found to have definite peripheral neuropathy and one had a probable case. Although one of these men had been exposed to lead in the past, there are strong reasons to believe that MBK was responsible for his neuropathy. There was nothing to suggest excessive lead absorption in the other two men.

(JAMA 235:1455-1457, 1976)

REFERENCES

1 +
Felton JS, Kahn E, Salick B, et al:  Heavy metal poisoning: Mercury and lead . Ann Intern Med 76:779-792, 1972;.
2 +
Schilling RSF, Fullerton PM, Barnes JM, et al:  Toxic chemicals and peripheral neuropathy . Proc R Soc Med 62:201-210, 1969;.
3 +
Cavanagh JB:  Peripheral neuropathy caused by chemical agents . CRC Crit Rev Toxicol 2:365-417, 1973;.
4 +
Herskowitz A, Ishii N, Schaumburg H:  N-hexane neuropathy: A syndrome occurring as a result of industrial exposure . N Engl J Med 285:82-85, 1971;.
5 +
Garland TO, Patterson MWH:  Six cases of acrylamide poisoning . Br Med J 4:134-138, 1967;.
6 +
Hunter D, Perry KMA, Evans RB:  Toxic polyneuritis arising during the manufacture of tri-cresyl phosphate . Br J Ind Med 1:227-231, 1944;.
7 +
Hunter D: The Diseases of Occupations . London, English University Press, 1955;, pp 357-363.
8 +
Billmaier D, Yee HT, Allen N, et al:  Peripheral neuropathy in a coated fabrics plant . J Occup Med 16:665-671, 1974;.
9 +
Mendell JR, Saida K, Ganansia MF, et al:  Toxic polyneuropathy produced by methyl N-butyl ketone . Science 185:787-789, 1974;.
10 +
Mayer RF:  Nerve conduction studies in man . Neurology 13:1021-1030, 1963;.
11 +
Baloh RW:  Laboratory diagnosis of increased lead absorption . Arch Environ Health 28:198-208, 1974;.
12 +
Prerovska I, Teisinger J:  Excretion of lead and its biological activity several years after termination of exposure . Br J Ind Med 27:352-355, 1970;.
13 +
Vitale LF, Joselow MM, Wedeen RP, et al:  Blood lead—an inadequate measure of occupational exposure . J Occup Med 17:155-156, 1975;.
14 +
Flink EB:  Heavy metal poisoning , in Beeson PB, McDermott W (eds): Cecil-Loeb Textbook of Medicine , ed 13. Philadelphia, WB Saunders Co, 1971;, pp 61-69.

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1 +
Felton JS, Kahn E, Salick B, et al:  Heavy metal poisoning: Mercury and lead . Ann Intern Med 76:779-792, 1972;.
2 +
Schilling RSF, Fullerton PM, Barnes JM, et al:  Toxic chemicals and peripheral neuropathy . Proc R Soc Med 62:201-210, 1969;.
3 +
Cavanagh JB:  Peripheral neuropathy caused by chemical agents . CRC Crit Rev Toxicol 2:365-417, 1973;.
4 +
Herskowitz A, Ishii N, Schaumburg H:  N-hexane neuropathy: A syndrome occurring as a result of industrial exposure . N Engl J Med 285:82-85, 1971;.
5 +
Garland TO, Patterson MWH:  Six cases of acrylamide poisoning . Br Med J 4:134-138, 1967;.
6 +
Hunter D, Perry KMA, Evans RB:  Toxic polyneuritis arising during the manufacture of tri-cresyl phosphate . Br J Ind Med 1:227-231, 1944;.
7 +
Hunter D: The Diseases of Occupations . London, English University Press, 1955;, pp 357-363.
8 +
Billmaier D, Yee HT, Allen N, et al:  Peripheral neuropathy in a coated fabrics plant . J Occup Med 16:665-671, 1974;.
9 +
Mendell JR, Saida K, Ganansia MF, et al:  Toxic polyneuropathy produced by methyl N-butyl ketone . Science 185:787-789, 1974;.
10 +
Mayer RF:  Nerve conduction studies in man . Neurology 13:1021-1030, 1963;.
11 +
Baloh RW:  Laboratory diagnosis of increased lead absorption . Arch Environ Health 28:198-208, 1974;.
12 +
Prerovska I, Teisinger J:  Excretion of lead and its biological activity several years after termination of exposure . Br J Ind Med 27:352-355, 1970;.
13 +
Vitale LF, Joselow MM, Wedeen RP, et al:  Blood lead—an inadequate measure of occupational exposure . J Occup Med 17:155-156, 1975;.
14 +
Flink EB:  Heavy metal poisoning , in Beeson PB, McDermott W (eds): Cecil-Loeb Textbook of Medicine , ed 13. Philadelphia, WB Saunders Co, 1971;, pp 61-69.

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