Cystic Fibrosis in a Black Woman FREE

Clifford W. Lober, MD; Hilliard F. Seigler, MD; Alexander Spock, MD

[+] Author Affiliations

Reprint requests to Department of Medicine, Mayo Clinic, Rochester, MN 55901 (Dr Lober).

JAMA. 1976;235(11):1140-1141. doi:10.1001/jama.1976.03260370048034

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ABSTRACT

ABSTRACT | REFERENCES

CYSTIC FIBROSIS is a genetic disease (autosomal recessive) considered to have a striking racial distribution. Kulczycki and Schauf¹ estimated that this disease affects one of every 17,033 black newborns and is therefore 10 to 15 times less prevalent among black Americans than among white Americans. To our knowledge, there is only one report in the literature of cystic fibrosis in a black person over 20 years old.²

Report of a Case A 22-year-old unmarried black secretary was seen by one of us (H.F.S.) in November 1972. She complained of a persistent, dull, abdominal pain. Since early childhood, she had had recurrent, aching abdominal discomfort and foul-smelling, floating stools. Two or three episodes of rectal prolapse had been noted each year since age 10. Many of her frequent "chest colds" (approximately ten each year) were accompanied by trace hemoptysis (< 5 ml), but she had never experienced massive hemoptysis.

REFERENCES

ABSTRACT | REFERENCES

Kulczycki LL, Schauf V: Cystic fibrosis in blacks in Washington, DC . Am J Dis Child 127:64-67, 1974;.

Di Sant'Agnese PA, Jones WO, Dische Z: Cystic fibrosis of the pancreas . Ann Intern Med 54:482-502, 1961;.

Senecal J, Toury J, LeMonze M, et al: Deux cas de fibrose kystique du pancreas chez l'enfant Africain realisant le syndrome du kwashiorkor . Bull Med Afr Occidentale Fr 11:95-99, 1954;.

Grove SS: Fibrocystic disease of the pancreas in the Bantu . South Afr J Lab Clin Med 5:113-119, 1959;.

MacDugall LG: Fibrocystic disease of the pancreas in African children . Lancet 2:409-410, 1962;.

Blumberg H, Zamit R, et al: Mucoviscidosis (cystic fibrosis of the pancreas) in Bantu twin neonates . South Afr Med J 41:482-485, 1967;.

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Pileggi A: Cystic fibrosis in a Negro . Del Med J 34:97-102, 1962;.

Oppenheimer EH, Esterly JR: Cystic fibrosis in noncaucasian patients . Pediatrics 42:547-548, 1968;.

Heffer ET: Cystic fibrosis in black population . NY State J Med 74:2355-2357, 1974;.

Brown PM, Hallenbeck GA, Soule EH, et al: Cystic fibrosis with fecal retention and intussusception in late stages . N Engl J Med 263:544-546, 1960;.

Beck AR, Aterman K: Intestinal obstruction and mucoviscidosis . Gastroenterologia 106:84-96, 1966;.

Murthy MSN, Herwig TF: Mucoviscidosis: Report of a case in a middle-aged adult . Ohio State Med J 69:768-771, 1973;.

Holsclaw DD, Rocmans C, Shwachman H: Abdominal complaints and appendiceal changes leading to the diagnosis of cystic fibrosis . J Pediatr Surg 9:867-873, 1974;.

Dolan TF, Meyers A: Mild cystic fibrosis presenting fibrosis an asymptomatic distended appendiceal mass: A case report . Clin Pediatr 14:862-863, 1975;.

Shwachman H, Holsclaw D: Examination of the appendix at laparotomy as a diagnostic clue in cystic fibrosis . N Engl J Med 286:1300-1301, 1972;.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal