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ARTICLE |

Migration of Plasticizer From Hemodialysis Blood Tubing: Title and subTitle BreakPreliminary Report FREE

Keiji Ono, MD; Ryo Tatsukawa, PhD; Tadaaki Wakimoto, PhD
[+] Author Affiliations

Reprint requests to 1-8-1 Yoshizuka Hakata-Ku Fukuoka, Japan 812 (Dr Ono).


JAMA. 1975;234(9):948-949. doi:10.1001/jama.1975.03260220052019
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Di-2-ethylhexyl phthalate was found to be migrating from polyvinyl chloride blood tubing into human blood during hemodialysis in 16 patients with end-stage renal failure. Although toxic effects have not yet been observed, we believe plastic tubing that does not contain extractable materials should be developed.

(JAMA 234:948-949, 1975)

REFERENCES

Quinton WC, Dillard D, Scribner BH:  Cannulation of blood vessels for prolonged hemodialysis . Trans Am Soc Artif Intern Organs 6:104-109, 1960;.
Brewer JH, Bryant HH:  The toxicity and safety testing of disposable medical and pharmaceutical materials . J Am Pharm Assoc 49:652-656, 1960;.
The Pharmacopeia of the United States of America , 17th revision. New York, United States Pharmacopeia, 1965;, pp 902-905.
Guess WL, Jacob J, Autian J:  Blood bag assemblies: I. Alteration or contamination of ACD solution . Drug Intell Clin Pharm 1:120-127, 1967;.
Jaeger RJ, Rubin RJ:  Contamination of blood stored in plastic packs . Lancet 2:151, 1970;.
Marcel YL, Noel SP:  Contamination of blood stored in plastic packs . Lancet 1:35-36, 1970;.
DeHaan RL:  Toxicity of tissue culture media exposed to polyvinyl chloride plastic . Nature 231:85-86, 1971;.
Neergaard J, Nielson B, Faurby V, et al:  Plasticizers in PVC and the occurrence of hepatitis in a hemodialysis unit . Scand J Urol Nephrol 5:141-145, 1971;.
Jaeger RJ, Rubin RJ:  Plasticizers from plastic devices: Extraction, metabolism, and accumulation by biological system . Science 170:460-462, 1970;.
Jaeger RJ, Rubin RJ:  Migration of a phthalate ester plasticizer from polyvinyl chloride blood bags into stored human blood and its localization in human tissue . N Engl J Med 287:1114-1118, 1972;.
Guess WL, Haberman S:  Toxicity profiles of vinyl and polyolefinic plastic and their additives . J Biomed Mater Res 2:313-335, 1968;.
Calley D, Autian J, Guess WE:  Toxicology of a series of phthalate ester . J Pharm Sci 55:158-162, 1966;.

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Quinton WC, Dillard D, Scribner BH:  Cannulation of blood vessels for prolonged hemodialysis . Trans Am Soc Artif Intern Organs 6:104-109, 1960;.
Brewer JH, Bryant HH:  The toxicity and safety testing of disposable medical and pharmaceutical materials . J Am Pharm Assoc 49:652-656, 1960;.
The Pharmacopeia of the United States of America , 17th revision. New York, United States Pharmacopeia, 1965;, pp 902-905.
Guess WL, Jacob J, Autian J:  Blood bag assemblies: I. Alteration or contamination of ACD solution . Drug Intell Clin Pharm 1:120-127, 1967;.
Jaeger RJ, Rubin RJ:  Contamination of blood stored in plastic packs . Lancet 2:151, 1970;.
Marcel YL, Noel SP:  Contamination of blood stored in plastic packs . Lancet 1:35-36, 1970;.
DeHaan RL:  Toxicity of tissue culture media exposed to polyvinyl chloride plastic . Nature 231:85-86, 1971;.
Neergaard J, Nielson B, Faurby V, et al:  Plasticizers in PVC and the occurrence of hepatitis in a hemodialysis unit . Scand J Urol Nephrol 5:141-145, 1971;.
Jaeger RJ, Rubin RJ:  Plasticizers from plastic devices: Extraction, metabolism, and accumulation by biological system . Science 170:460-462, 1970;.
Jaeger RJ, Rubin RJ:  Migration of a phthalate ester plasticizer from polyvinyl chloride blood bags into stored human blood and its localization in human tissue . N Engl J Med 287:1114-1118, 1972;.
Guess WL, Haberman S:  Toxicity profiles of vinyl and polyolefinic plastic and their additives . J Biomed Mater Res 2:313-335, 1968;.
Calley D, Autian J, Guess WE:  Toxicology of a series of phthalate ester . J Pharm Sci 55:158-162, 1966;.
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