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November 3, 1975, Vol 234, No. 5 >
ARTICLE | November 3, 1975

Phencyclidine: Title and subTitle BreakNine Cases of Poisoning FREE

Craig B. Liden, MD; Frederick H. Lovejoy, Jr., MD; Catherine E. Costello, PhD
[+] Author Affiliations

Read in part before the American Association of Poison Control Centers, San Francisco, Oct 21, 1974.

Reprint requests to Children's Hospital Medical Center, 300 Longwood Ave, Boston, MA 02115 (Dr. Lovejoy).


JAMA. 1975;234(5):513-516. doi:10.1001/jama.1975.03260180053024
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References

In nine cases of phencyclidine hydrochloride poisoning, early signs of overdose included drowsiness, nystagmus, miotic pupils, blood pressure elevation, increased deep tendon reflexes, ataxia, anxiety, and agitation. In more severe cases, seizures, spasticity, and opisthotonos were seen in addition to deep coma and respiratory depression. Treatment included removal by emetics or lavage, hydration, and a quiet, reassuring environment. Spasticity, agitation, and ocular manifestions responded to diazepam. Psychiatric intervention was instituted after the patients were stable and no longer agitated.

(JAMA 234:513-516, 1975)

REFERENCES

1 +
Hart JB, McChesney JC, Grief M, et al:  Composition of illicit drugs and use of drug analysis and abuse abatement . J Psychedelic Drugs 5:83-88, 1972;.
2 +
Phencyclidine National Clearinghouse for Drug Abuse Information Series No. 14, No. 1, April 1973.
3 +
Meyers FH, Rose AJ, Smith DH:  Incidents involving the Haight-Ashbury population and some uncommonly used drugs . J Psychedelic Drugs 1:139-146, 1967;/1968.
4 +
Domino EF:  Neurobiology of phencyclidine . Int Rev Neurobiol 6:303-347, 1964;.
5 +
Davies BM, Beech HR:  The effect of 1-arylcyclohexylamine (Sernyl) on 12 normal volunteers . J Ment Sci 106:912-924, 1960;.
6 +
Neubauer H, Sundland DM, Gershon S:  Sernyl, Ditran and their antagonists: Succinate and THA . Int J Neuropsych 2:216-222, 1966;.
7 +
Gershon S. Olariu J:  JB 329—A new psychotomimetic: Its antagonism by THA and its comparison with LSD, mescaline and Sernyl . J Neuropsych 1:283-292, 1960;.
8 +
Greifenstein FE, DeVault M, Yoshetake J, et al:  A study of 1-aryl-cyclohexyl-amine for anesthesia . Anesth Analg 37:283-294, 1964;.
9 +
Chen G, Enson C, Russell D, et al:  The pharmacology of 1-(1-phenylcyclohexyl) piperidine HC1 . J Pharmacol Exp Ther 127:241-250, 1959;.
10 +
Meyer JS, Greifenstein F, DeVault M:  A new drug causing symptoms of sensory deprivation: Neurological, electroencephalographic and pharmacological effects of Sernyl . J Nerv Ment Dis 129:54-61, 1959;.
11 +
Ban TA, Lohrenz JJ, Lehmann HE:  Observations on the action of Sernyl—a new psychotropicdrug . Can Psychiatr Assoc J 6:150-156, 1961;.
12 +
Luby ED, Cohen BD, Rosenbaum G, et al:  Study of a new schizophrenomimetic drug—Sernyl . Arch Neurol Psychiatry 81:363-369, 1959;.
13 +
Rosenbaum G, Cohen BD, Luby ED, et al:  Comparison of Serynl with other drugs . Arch Gen Psychiatry 1:651-656, 1959;.
14 +
Cohen BD, Luby ED, Rosenbaum G, et al:  Combined Serynl and sensory deprivation . Compr Psychiatry 1:345-348, 1960;.
15 +
Lampe M: Drugs: Information for Crisis Treatment . Beloit, Wis, Student Association for the Study of Hallucinogens, 1971;, p 5.
16 +
Chen G, Ensor C, Bohner B:  An investigation of the sympathomimetic properties of phencyclidine by comparison with cocaine and desoxyephedrine . J Pharmacol Exp Ther 149:71-78, 1965;.
17 +
Liden CB, Lovejoy FH Jr, Costello CE:  Phencyclidine poisoning . J Pediatr 83:844-845, 1973;.
18 +
Costello CE, Hertz HS, Sakai T, et al:  Routine use of flexible gas chromatograph-mass spectrometer-computer system to identify drugs and their metabolites in body fluids of overdose victims . Clin Chem 20:255-265, 1974;.
19 +
Stein JI:  Phencyclidine-induced psychosis: The need to avoid unnecessary sensory influ . Milit Med J 138:590-591, 1973;.

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1 +
Hart JB, McChesney JC, Grief M, et al:  Composition of illicit drugs and use of drug analysis and abuse abatement . J Psychedelic Drugs 5:83-88, 1972;.
2 +
Phencyclidine National Clearinghouse for Drug Abuse Information Series No. 14, No. 1, April 1973.
3 +
Meyers FH, Rose AJ, Smith DH:  Incidents involving the Haight-Ashbury population and some uncommonly used drugs . J Psychedelic Drugs 1:139-146, 1967;/1968.
4 +
Domino EF:  Neurobiology of phencyclidine . Int Rev Neurobiol 6:303-347, 1964;.
5 +
Davies BM, Beech HR:  The effect of 1-arylcyclohexylamine (Sernyl) on 12 normal volunteers . J Ment Sci 106:912-924, 1960;.
6 +
Neubauer H, Sundland DM, Gershon S:  Sernyl, Ditran and their antagonists: Succinate and THA . Int J Neuropsych 2:216-222, 1966;.
7 +
Gershon S. Olariu J:  JB 329—A new psychotomimetic: Its antagonism by THA and its comparison with LSD, mescaline and Sernyl . J Neuropsych 1:283-292, 1960;.
8 +
Greifenstein FE, DeVault M, Yoshetake J, et al:  A study of 1-aryl-cyclohexyl-amine for anesthesia . Anesth Analg 37:283-294, 1964;.
9 +
Chen G, Enson C, Russell D, et al:  The pharmacology of 1-(1-phenylcyclohexyl) piperidine HC1 . J Pharmacol Exp Ther 127:241-250, 1959;.
10 +
Meyer JS, Greifenstein F, DeVault M:  A new drug causing symptoms of sensory deprivation: Neurological, electroencephalographic and pharmacological effects of Sernyl . J Nerv Ment Dis 129:54-61, 1959;.
11 +
Ban TA, Lohrenz JJ, Lehmann HE:  Observations on the action of Sernyl—a new psychotropicdrug . Can Psychiatr Assoc J 6:150-156, 1961;.
12 +
Luby ED, Cohen BD, Rosenbaum G, et al:  Study of a new schizophrenomimetic drug—Sernyl . Arch Neurol Psychiatry 81:363-369, 1959;.
13 +
Rosenbaum G, Cohen BD, Luby ED, et al:  Comparison of Serynl with other drugs . Arch Gen Psychiatry 1:651-656, 1959;.
14 +
Cohen BD, Luby ED, Rosenbaum G, et al:  Combined Serynl and sensory deprivation . Compr Psychiatry 1:345-348, 1960;.
15 +
Lampe M: Drugs: Information for Crisis Treatment . Beloit, Wis, Student Association for the Study of Hallucinogens, 1971;, p 5.
16 +
Chen G, Ensor C, Bohner B:  An investigation of the sympathomimetic properties of phencyclidine by comparison with cocaine and desoxyephedrine . J Pharmacol Exp Ther 149:71-78, 1965;.
17 +
Liden CB, Lovejoy FH Jr, Costello CE:  Phencyclidine poisoning . J Pediatr 83:844-845, 1973;.
18 +
Costello CE, Hertz HS, Sakai T, et al:  Routine use of flexible gas chromatograph-mass spectrometer-computer system to identify drugs and their metabolites in body fluids of overdose victims . Clin Chem 20:255-265, 1974;.
19 +
Stein JI:  Phencyclidine-induced psychosis: The need to avoid unnecessary sensory influ . Milit Med J 138:590-591, 1973;.

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